9,681 research outputs found
Demographic, socioeconomic, and health correlates of unmet need for mental health treatment in the United States, 2002â16: evidence from the national surveys on drug use and health
Abstract: Background: Unmet need for mental health services remains high in the United States and is disproportionately concentrated in some groups. The scale and nature of these disparities have not been fully elucidated and bear further scrutiny. As such, in this study, we examine the demographic, socioeconomic, and health correlates of unmet need for mental health treatment as well as the reasons for unmet need. Methods: We draw upon the National Survey for Drug Use and Health (NSDUH) from 2002 to 16 for adults aged 18 and over in the United States (n = 579,017). Using multivariable logistic regression, we simultaneously model the demographic, socioeconomic, and health correlates of unmet need for mental health treatment from 2002 to 16. We also analyse the reasons for unmet need expressed by these populations, reasons which include cost, perceived stigma, minimisation of symptoms, low perceived effectiveness of treatment, and structural barriers. Results: Major characteristics associated with increased odds of unmet need include past year substance abuse or dependence (other than hallucinogens and sedatives), fair, poor, or very poor health, being female, and an educational attainment of college or higher. With respect to reasons for unmet need, cost was most often cited, followed by perceived stigma, structural barriers, and minimisation. Characteristics associated with increased odds of indicating cost as a reason for unmet need include: being uninsured or aged 26â35. Minimisation and low perceived effectiveness are mentioned by high-income persons as reasons for unmet need. College-educated persons and women had higher odds of citing structural barriers as a reason for unmet need. Conclusions: The correlates and causes of unmet need highlight the intersectionality of individual health needs with implications on addressing inequities in mental health policy and practice
The story of the 310th infantry regiment, 78th infantry division in the war against Germany, 1942-1945
The 310th Infantry Regiment has fought in more than one war. This history is primarily an account of the present 310th Infantry Regiment in World War II, but there is a story to tell of an earlier 310th Regiment which carried the same Regimental Colors into battle against the German enemy in World War I.https://digicom.bpl.lib.me.us/ww_reg_his/1038/thumbnail.jp
Presidential Succession: Communication from the President of the United States: Recommending Revision of the Laws as Suggested in His Message to Congress of June 19, 1945
President Harry Truman\u27s second message to Congress calling for the inclusion of legislators in the line succession. Congress approved such a statute five months later. That statute remains in effect.https://ir.lawnet.fordham.edu/twentyfifth_amendment_executive_materials/1005/thumbnail.jp
Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)
<p>Abstract</p> <p>Background</p> <p>Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer death in the USA. Recurrence rates are high after front-line therapy and most patients eventually die from platinum (Pt) - resistant disease. Cisplatin resistance is associated with increased nucleotide excision repair (NER), decreased mismatch repair (MMR) and decreased platinum uptake. The objective of this study is to investigate how a novel combination of sodium arsenite (NaAsO<sub>2</sub>) and hyperthermia (43°C) affect mechanisms of cisplatin resistance in ovarian cancer.</p> <p>Methods</p> <p>We established a murine model of metastatic EOC by intraperitoneal injection of A2780/CP70 human ovarian cancer cells into nude mice. We developed a murine hyperthermic intraperitoneal chemotherapy model to treat the mice. Mice with peritoneal metastasis were perfused for 1 h with 3 mg/kg cisplatin ¹ 26 mg/kg NaAsO<sub>2 </sub>at 37 or 43°C. Tumors and tissues were collected at 0 and 24 h after treatment.</p> <p>Results</p> <p>Western blot analysis of p53 and key NER proteins (ERCC1, XPC and XPA) and MMR protein (MSH2) suggested that cisplatin induced p53, XPC and XPA and suppressed MSH2 consistent with resistant phenotype. Hyperthermia suppressed cisplatin-induced XPC and prevented the induction of XPA by cisplatin, but it had no effect on Pt uptake or retention in tumors. NaAsO<sub>2 </sub>prevented XPC induction by cisplatin; it maintained higher levels of MSH2 in tumors and enhanced initial accumulation of Pt in tumors. Combined NaAsO<sub>2 </sub>and hyperthermia decreased cisplatin-induced XPC 24 h after perfusion, maintained higher levels of MSH2 in tumors and significantly increased initial accumulation of Pt in tumors. ERCC1 levels were generally low except for NaAsO<sub>2 </sub>co-treatment with cisplatin. Systemic Pt and arsenic accumulation for all treatment conditions were in the order: kidney > liver = spleen > heart > brain and liver > kidney = spleen > heart > brain respectively. Metal levels generally decreased in systemic tissues within 24 h after treatment.</p> <p>Conclusion</p> <p>NaAsO<sub>2 </sub>and/or hyperthermia have the potential to sensitize tumors to cisplatin by inhibiting NER, maintaining functional MMR and enhancing tumor platinum uptake.</p
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A model-based assessment of the effects of projected climate change on the water resources of Jordan
This paper is concerned with the quantification of the likely effect of anthropogenic climate change on the water resources of Jordan by the end of the twenty-first century. Specifically, a suite of hydrological models are used in conjunction with modelled outcomes from a regional climate model, HadRM3, and a weather generator to determine how future flows in the upper River Jordan and in the Wadi Faynan may change. The results indicate that groundwater will play an important role in the water security of the country as irrigation demands increase. Given future projections of reduced winter rainfall and increased near-surface air temperatures, the already low groundwater recharge will decrease further. Interestingly, the modelled discharge at the Wadi Faynan indicates that extreme flood flows will increase in magnitude, despite a decrease in the mean annual rainfall. Simulations projected no increase in flood magnitude in the upper River Jordan. Discussion focuses on the utility of the modelling framework, the problems of making quantitative forecasts and the implications of reduced water availability in Jordan
Order of dismissal - Civil Action No. B-08-56
Order of dismissal in United States of America v. 37.52 ACRES OF LAND, more or less, situate in CAMERON COUNTY, STATE OF TEXAS; and TEXAS SOUTHMOST COLLEGE DISTRICT, ET AL.https://scholarworks.utrgv.edu/bwbsdocuments/1000/thumbnail.jp
The Budget of the United States Government for the Fiscal Year ending June 30, 1953
This excerpt from the US Government yearly budget, dated January 1, 1952, indicates a payment to the Three Affiliated Tribes of Fort Berthold Reservation in the amount of 7.5 million dollars. This payment is noted in the section âBureau of Indian Affairsâ under the subsection âMiscellaneous Expired Accounts, Bureau of Indian Affairsâ and is labeled an âexpenditure out of prior authorization.âhttps://commons.und.edu/indigenous-gov-docs/1029/thumbnail.jp
Molecular Cloud Structure in the Magellanic Clouds: Effect of Metallicity
The chemical structure of neutral clouds in low metallicity environments is
examined with particular emphasis on the H to H_2 and C+ to CO transitions. We
observed near-IR H_2 lines and the CO J=1-0 line from 30 Doradus and N159/N160
in the Large Magellanic Cloud and from DEM S 16, DEM S 37, and LI-SMC 36 in the
Small Magellanic Cloud. We find that the H_2 emission is UV-excited and that
(weak) CO emission always exists (in our surveyed regions) toward positions
where H_2 and [CII] emission have been detected. Using a PDR code and a
radiative transfer code, we simulate the emission of line radiation from
spherical clouds and from large planar clouds. Because the [CII] emission and
H_2 emission arise on the surface of the cloud and the lines are optically
thin, these lines are not affected by changes in the relative sizes of the
neutral cloud and the CO bearing core, while the optically thick CO emission
can be strongly affected. The sizes of clouds are estimated by measuring the
deviation of CO emission strength from that predicted by a planar cloud model
of a given size. The average cloud column density and therefore size increases
as the metallicity decreases. Our result agrees with the photoionization
regulated star formation theory by Mc Kee (1989).Comment: 45 Pages including 15 figures. To be published in the ApJ May 10,
1998 issue, Vol. 49
The 68th Tank Battalion in combat
This will be the record of the 68th Tank Battalion\u27s participation in successive campaigns from the historic breakthrough in Normandy to VE Day in the heart of Germany. Before beginning this narrative, however, there are some remarks we must make.
Firstly, this history was made possible by the heroically spent blood and sweat of American men, who gave their best for their country. They did well, these men, and though some of them are no longer with us, their deeds will never be forgotten.https://digicom.bpl.lib.me.us/ww_reg_his/1003/thumbnail.jp
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