RAPID BLEEDING REGION DETECTION IN WIRELESS CAPSULE ENDOSCOPY VIDEOS

Wireless Capsule Endoscopy (WCC) is a medical imaging technique used to examine parts of the gastrointestinal tract. Computer aided detection is used to increase the speed of detection, better performance and reduce the time. Before finding the bleeding regions the edge regions are first detected and removed. Both the edge and the bleeding regions will share the same Hue value and the luminance should be same for the bleeding and the non -bleeding regions .We use a canny edge detector operator for detecting the edge regions in L channel. Canny edge detector is used to detect more edge pixels and preserve more bleeding pixels based up on canny edge algorithm. This method in edge removal algorithm includes edge detection, edge dilation and edge masking. After the removal of edges, those regions are made in to segment through super-pixel segmentation and regions are classified using Artificial Neural Network by Radial Bias Function (RBF).Â

Ecosystem Services for Disaster Risk Reduction: A Case Study of Wetland in East Delhi Region, India

Ecosystem services are the benefits that societies receive from the nature These may be in the form of regulating provisioning supporting or cultural services Wetland being one of the most productive ecosystems provides these services at no cost These ecosystems also contribute to reducing disaster risk by serving as natural protective barriers or buffers and thus mitigating hazard impacts But many such wetland ecosystems are tremendous stressed due to anthropogenic pressure Wetlands on the fringes of river channels in the city are looked upon as a resource for different land use planning The capital Delhi manifests all the ills that a river system Yamuna can possibly face made the city more vulnerable and disaster prone as evident from frequent incidences of flood water crisis and disease outbreak Rapidly increasing urbanisation with limited integration of values and functions of floodplains in developmental planning has led to their fragmentation This study is an attempt to assess the present state of ecosystems its services particularly in reducing the risk of water and climate related disasters like flood drought and epidemics in East Delhi and part of National Capital Refio

Rapidly Convergent Series from Positive Term Series

In this paper we shall give description about the extraction of a rapidly decaying remainder from Euler series and telescoping series. Then we apply the procedure to generalised telescoping series. The new positive term series obtained with rapidly decaying remainder will converge faster than the original series. We shall apply the procedure to generalised telescoping series also. The introduction of such remainder will give a better approximation for the series

Star formation in the region of young open cluster - NGC 225

NGC 225 is believed to be a 120 Myr old open cluster located at ∼ 650 pc. Eight stars with Hα emission are found to be located around the cluster, of which two are probable Herbig Be stars, indicating a very young age for the cluster. To explore whether the Herbig Be stars, which are premain sequence (PMS) stars are part of this cluster, we re-estimated the cluster parameters using optical (UBV)pg and 2MASS JHK photometry. We combined the above data to detect the presence of any possible PMS stars in the cluster region. Among the identified 28 proper motion members, 15 stars were found to have near-infrared (NIR) excess indicating that they are PMS stars. Also, most of the upper MS stars were found to show NIR excess suggesting that the brighter proper motion member stars have not yet reached the MS. PMS isochrones were used to estimate the age of stars with NIR excess and is found to be between 0.5–10 Myr. Thus, the cluster NGC 225 is a very young cluster, younger than 10 Myr and its age is not 120 Myr as previously believed. We propose that a recent star formation has resulted in the formation of NGC 225, two Herbig Be stars, stars with Hα emission, dust lanes and nebulosity in the vicinity of the cluster

STATUS OF ENZYMATIC ANTIOXIDANTS IN EYE LENS EXTRACTED FROM CATARACTOUS SUBJECTS

Objectives: Cataract is a common kind of blindness prevailing in India. Eye lens is normally exposed to toxic elements of the surroundings, leading to the formation of free radicals. In normal conditions, the presence of antioxidants may help to counteract the progression of free radical formation in an eye lens. Hence, it was requisite to assess the activities of enzymatic antioxidants in the eye lens extracted from cataractous subjects.Methods: The cataractous lens samples of 120 subjects were collected from the ophthalmic centres in and around Coimbatore. The subjects were categorised into apparently normal cataract men (ACM), apparently normal cataract women (ACW), diabetic cataract men (DCM), diabetic cataract women (DCW), hypertensive cataract men (HCM) and hypertensive cataract women (HCW) with each group consisting of 20 samples. Activities of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) were assessed in the cataractous lens samples from the selected subjects. Data was interpreted using SPSS 16.0 software package.Results: The activities of SOD and CAT were found to be significantly decreased (p<0.05) in all the five groups when compared to apparently normal cataract men. Enzymes of glutathione system exhibited a significant variation (p<0.05) in their activity in the cataractous eye lens extracted from diabetic and hypertensive cataract women in comparison to apparently normal cataract men. A significant decrease (p<0.05) in the activities of GR and GST was also observed in the cataractous eye lens extracted from diabetic and hypertensive cataract men when compared to the subjects of ACM group. Conclusion: The outcome of the study suggested that cataractous subjects with clinical complications were much disposed to the reactive oxygen species and more affected than the apparently normal cataractous subjects. Â

ENZYMOSOMES: A RISING EFFECTUAL TOOL FOR TARGETED DRUG DELIVERY SYSTEM

The study aims to develop enzymosomes as an emerging novel drug delivery system for site-specific action. Enzymosomes utilises the specific nature of an enzyme, which is binding to a specific substrate at a controlled rate and catalysing product production step. An enzyme is encapsulated by coupling covalently to the surface of liposomes/lipid vesicles to form enzymosomes. Enzymes links through acylation, direct conjugation, physical adsorption, encapsulation methods to prepare enzymosomes with targeted action. Such novel drug delivery systems prove effective drug release and concomitantly reduces undesirable side effects of conventional treatment methods and hence showcase improvement in the long-term therapy of the disease. They are a promising substitute to conventional treatment therapies of gout, antiplatelet activities etc. Enzymosomes are newly designed supramolecular vesicular delivery systems to be useful as a tool in pharmaceutics for the raising of drug targeting and physicochemical properties and hence bioavailability. It shows beneficial effects of drugs with a narrow precision because targeting of these drugs to their site of action improves the drugs overall pharmacodynamics and pharmacokinetic profile. It also minimizes alterations in the normal enzymatic activity, thus enhancing half-life and achieve enzyme activity on targeted sites such as cancerous cells

A CROSS-SECTIONAL STUDY ON ACCEPTANCE AND POST-VACCINATION SYMPTOMS OF COVID-19 VACCINATION IN INDIA

Objectives: The fastidious development of the COVID-19 vaccine is a vital achievement for the country and early data suggest that it is both safe and efficacious, however, the acceptance of the COVID-19 vaccine is still a major concern as it depends on the individual decision and sociodemographic characteristics. The main objective of our study is to assess the vaccine acceptance among Indians and study about post-vaccination symptoms to identify potential concerns to be addressed to ensure vaccine safety. Methods: An online cross-sectional study was conducted using Google Forms over a period of 1 week on the general population. Data were collected which included the questions regarding participant demographics, vaccination details, and their health status. Microsoft Excel was used for recording and analyzing the collected data. Results: Out of 1016 respondents, 52% were male and 47.6% were female. Most of the respondents perfectly accept the vaccine, 35.5% are neutral and 5.9% are unacceptable toward vaccination. Post the vaccination of both doses, the occurrence of fever and chills is more common in the case of the first dose, whereas rashes are more common in the second dose, muscle pain and joint pain are common in both doses. Conclusion: This community-based project on acceptance and post-vaccination symptoms of vaccination among Indians reveals that the majority of participants showed a positive acceptance rate toward the vaccination but most of them are worried about the risk of side effects. In regard to post-vaccination symptoms, mild fever and chills are the most common side effect in the case of the first dose of vaccination, whereas muscle/joint pain was seen commonly in both the first and second doses of vaccination

ANTI-EPILEPTIC DRUG LOADED NIOSOMAL TRANSDERMAL PATCH FOR ENHANCED SKIN PERMEATION

Objective: To formulate and characterize midazolam loaded niosomal transdermal patches for overcoming the frequent dosing and lower bioavailability complications associated with conventional therapy. Methods: The loaded niosomal transdermal patches were prepared by thin film hydration method. The preliminary evaluation and characterization studies was conducted to find the optimised formulation. The in vitro release and ex-vivo permeation studies were investigated. The histopathological studies and stability studies were also assessed. Results: The midazolam loaded niosomal transdermal patches of vesicle size and zeta potential 116.1±84.46 d. nm and 8.56±1.2 mV respectively was formulated. The characterizations of both niosome and niosomal transdermal patches were found to be within the acceptable limits. The in vitro drug release showed an initial burst release followed by sustained release for both optimised niosomal formulation N5 and optimised niosomal transdermal patch formulation NT5with a maximum activity at 97.3±0.35% and 98.9±0.20% respectively. The ex vivo permeation studies of niosomal transdermal patch NT5 was performed which showed a higher permeability than control solution with a flux value of 0.151. The histopathological studies of the optimised formulation showed no detectable lesions upon skin surface and irritations. The stability studies showed that patches were stable over 90 d in different atmospheric conditions. Conclusion: The midazolam loaded niosomal transdermal patch was found to be a promising nano drug delivery alternative which showed better entrapment, release with permeation profile for the daily management of epilepsy with decreased dosing frequency