30 research outputs found
An improved procedure for the three-component synthesis of highly substituted pyridines using ionic liquid
A basic ionic liquid, [bmIm]OH, efficiently promotes a one-pot, three-component condensation of aldehydes, malononitrile, and thiophenols to produce highly substituted pyridines in high yields at room temperature. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid is recovered and recycled for subsequent reactions
Organocatalyzed One-Step Synthesis of Functionalized <i>N-</i>Alkyl-Pyridinium Salts from Biomass Derived 5âHydroxymethylfurfural
An efficient and scalable method
has been developed for the synthesis
of <i>N-</i>alkylpyridinium salts from biomass derived 5-hydroxymethylÂfurfural
and alkyl amines using a catalytic amount of formic acid. This protocol
is also extended to various diamines providing the exclusive formation
of mono-<i>N-</i>alkylpyridinium salts. In addition, the
mechanism for the formation of pyridinium salts was studied by DFT
and using H<sub>2</sub><sup>18</sup>O isotope labeled experiments
showing no incorporation of <sup>18</sup>O in the product