289 research outputs found
Non-collinear magnetism in iron at high pressures
Using a first principles based, magnetic tight-binding total energy model,
the magnetization energy and moments are computed for various ordered spin
configurations in the high pressure polymorphs of iron (fcc, or -Fe,
and hcp, or -Fe), as well ferromagnetic bcc iron (-Fe). For
hcp, a non-collinear, antiferromagnetic, spin configuration that minimizes
unfavorable ferromagnetic nearest neighbor ordering is the lowest energy state
and is more stable than non-magnetic iron up to about 75 GPa.
Accounting for non-collinear magnetism yields better agreement with the
experimental equation of state, in contrast to the non-magnetic equation of
state, which is in poor agreement with experiment below 50 GPa
Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
BACKGROUND: Increased knowledge of the evolution of molecular changes in neurodegenerative disorders such as Alzheimer's disease (AD) is important for the understanding of disease pathophysiology and also crucial to be able to identify and validate disease biomarkers. While several biological changes that occur early in the disease development have already been recognized, the need for further characterization of the pathophysiological mechanisms behind AD still remains. METHODS: In this study, we investigated cerebrospinal fluid (CSF) levels of 104 proteins in 307 asymptomatic 70-year-olds from the H70 Gothenburg Birth Cohort Studies using a multiplexed antibody- and bead-based technology. RESULTS: The protein levels were first correlated with the core AD CSF biomarker concentrations of total tau, phospho-tau and amyloid beta (Aβ42) in all individuals. Sixty-three proteins showed significant correlations to either total tau, phospho-tau or Aβ42. Thereafter, individuals were divided based on CSF Aβ42/Aβ40 ratio and Clinical Dementia Rating (CDR) score to determine if early changes in pathology and cognition had an effect on the correlations. We compared the associations of the analysed proteins with CSF markers between groups and found 33 proteins displaying significantly different associations for amyloid-positive individuals and amyloid-negative individuals, as defined by the CSF Aβ42/Aβ40 ratio. No differences in the associations could be seen for individuals divided by CDR score. CONCLUSIONS: We identified a series of transmembrane proteins, proteins associated with or anchored to the plasma membrane, and proteins involved in or connected to synaptic vesicle transport to be associated with CSF biomarkers of amyloid and tau pathology in AD. Further studies are needed to explore these proteins' role in AD pathophysiology
First Principles Calculations of Fe on GaAs (100)
We have calculated from first principles the electronic structure of 0.5
monolayer upto 5 monolayer thick Fe layers on top of a GaAs (100) surface. We
find the Fe magnetic moment to be determined by the Fe-As distance. As
segregates to the top of the Fe film, whereas Ga most likely is found within
the Fe film. Moreover, we find an asymmetric in-plane contraction of our
unit-cell along with an expansion perpendicular to the surface. We predict the
number of Fe 3d-holes to increase with increasing Fe thickness on -doped
GaAs.Comment: 9 pages, 14 figures, submitted to PR
Study of the pressure effects in TiOCl by ab initio calculations
Electronic structure calculations on the low dimensional spin-1/2 compound
TiOCl were performed at several pressures in the orthorhombic phase, finding
that the structure is quasi-one-dimensional. The Ti3+ (d1) ions have one t2g
orbital occupied (dyz) with a large hopping integral along the b direction of
the crystal. The most important magnetic coupling is Ti-Ti along the b axis.
The transition temperature (Tc) has a linear evolution with pressure, and at
about 10 GPa this Tc is close to room temperature, leading to a room
temperature spin-Peierls insulator-insulator transition, with an important
reduction of the charge gap in agreement with the experiment. On the
high-pressure monoclinic phase, TiOCl presents two possible dimerized
structures, with a long or short dimerization. Long dimerized state occurs
above 15 GPa, and below this pressure the short dimerized structure is the more
stable phase.Comment: 3 pages, 3 embedded figures, 1 table. A. Pi\~neiro, et al.,J. Magn.
Magn. Mater. (2009) (accepted
Identification of Genes Contributing to the Virulence of Francisella tularensis SCHU S4 in a Mouse Intradermal Infection Model
Background: Francisella tularensis is a highly virulent human pathogen. The most virulent strains belong to subspecies tularensis and these strains cause a sometimes fatal disease. Despite an intense recent research effort, there is very limited information available that explains the unique features of subspecies tularensis strains that distinguish them from other F. tularensis strains and that explain their high virulence. Here we report the use of targeted mutagenesis to investigate the roles of various genes or pathways for the virulence of strain SCHU S4, the type strain of subspecies tularensis. Methodology/Principal Findings: The virulence of SCHU S4 mutants was assessed by following the outcome of infection after intradermal administration of graded doses of bacteria. By this route, the LD\u2085\u2080 of the SCHU S4 strain is one CFU. The virulence of 20 in-frame deletion mutants and 37 transposon mutants was assessed. A majority of the mutants did not show increased prolonged time to death, among them notably \u394pyrB and \u394recA. Of the remaining, mutations in six unique targets, tolC, rep, FTT0609, FTT1149c, ahpC, and hfq resulted in significantly prolonged time to death and mutations in nine targets, rplA, wbtI, iglB, iglD, purL, purF, ggt, kdtA, and glpX, led to marked attenuation with an LD\u2085\u2080 of >10\ub3 CFU. In fact, the latter seven mutants showed very marked attenuation with an LD\u2085\u2080 of 6510\u2077 CFU. Conclusions/Significance: The results demonstrate that the characterization of targeted mutants yielded important information about essential virulence determinants that will help to identify the so far little understood extreme virulence of F. tularensis subspecies tularensis.Peer reviewed: YesNRC publication: Ye
- …