Corneal aberration changes after rigid gas permeable contact lens wear in keratokonic patients

Purpose To determine the short-term effect of rigid gas permeable (RGP) contact lenses on corneal aberrations in keratoconic patients. Method Sixteen keratoconic eyes with no history of RGP lens wear were included. They all had corneal aberrometry using Pentacam, and different aberration indices of the anterior and posterior surfaces of the cornea were measured before and 3 months after fitting RGP lenses. The effect of baseline parameters on these changes was tested in univariate and multiple models. Results Total aberrations and individual Zernike coefficients did not show statistically significant changes after using RGP lenses. Although not statistically significant, vertical coma decreased in the anterior (p = 0.073) and posterior surface (p = 0.095). Relationships that remained statistically significant in the multiple model were between baseline central corneal thickness and changes in total higher order aberrations and anterior 4th order astigmatism 0°, and between baseline 2nd order astigmatism 45° and its changes. Conclusion In this study, corneal aberrations remained unchanged 3 months after wearing RGP contact lens. Further studies with sufficient samples in different groups of keratoconus severity or baseline aberrations are needed to obtain more accurate results. © 2016 Iranian Society of Ophthalmolog

Determination of total and available fractions of PAHs by SPME in oily wastewaters : overcoming interference from NAPL and NOM

Background, aim, and scope Polycyclic aromatic hydrocarbons (PAHs) are often found in oily wastewaters. Their presence is usually the result of human activities and has a negative effect on the environment. One important step in addressing this problem is to evaluate the effectiveness of PAH removal by biological processes since these are the most cost-effective treatments known today. Many techniques are presently available for PAH determination in wastewaters. Solid phase microextracion (SPME) is known to be one of the most effective techniques for this purpose. When analyzing complex matrices with substances such as natural organic matter (NOM) and non-aqueous phase liquids (NAPL), it is important to differentiate the free dissolved PAH from matrix-bonded PAH. PAHs associated with the bonded fraction are less susceptible to biological treatment. The present study concerns the development of a simple and suitable methodology for the determination of the freely dissolved and the total fraction of PAHs present in oily wastewaters. The methodology was then applied to an oily wastewater from a fuel station retention basin. Material and methods Headspace SPME was used for analyzing PAH since the presence of a complex or dirty matrix in direct contact with the fiber may damage it. Four model PAHs—anthracene, fluorene, phenanthrene, and pyrene—were analyzed by GC-MS. Negligible depletion SPME technique was used to determine the free fraction. Total PAH was determined by enhancing the mass transfer from the bonded phase to the freely dissolved phase by temperature optimization and the use of the method of standard additions. The PAH absorption kinetics were determined in order to define the optimal sampling conditions for this method. The fitting of the experimental data to a mathematical model was accomplished using Berkeley Madonna software. Humic acid and silicon oil were used as model NOM and NAPL, respectively, to study the effect of these compounds on the decrease of SPME response. Then, the method was evaluated with wastewater from a fuel station spill retention basin. Results The SPME kinetic parameters—k 1 (uptake rate), k 2 (desorption rate), and K SPME (partition coefficient)—were determined from experimental data modeling. The determination of the free fraction required 15-min sampling to ensure that PAH depletion from sample was below 1%. For total PAH, a 30-min extraction at 100°C ensured the maximum signal response in the GC-MS. For the determination of free and total PAHs, extractions were performed before reaching the SPME equilibrium. The wastewater used in this study had no free fraction of the analyzed PAHs. However, the four studied PAHs were found when the method for total PAH was used. Discussion The addition of NOM and NAPL dramatically decreased the efficiency of the SPME. This decrease was the result of a greater partition of the PAHs to the NAPL and NOM phases. This fact was also observed in the analysis of the fuel station spill retention basin, where no free PAH was measured. However, using the method of standard addition for the determination of total PAH, it was possible to quantify all four PAHs. Conclusions The method developed in the present study was found to be adequate to differentiate between free and total PAH present in oily wastewater. It was determined that the presence of NOM and NAPL had a negative effect on SPME efficiency. Recommendations and perspectives The presence of binding substances had a great influence on SPME kinetics. Therefore, it is of extreme importance to determine their degree of interference when analyzing oily wastewaters or results can otherwise be erroneous. Other factors influencing the total PAH determinations should be considered in further studies.Fundação para a Ciência e a Tecnologia (FCT) - SFRH/BD/ 18816/2004, POCI/AMB/61044/200

Embedded analytical-numerical simulation of fault reactivation in heterogeneous subsurface formations: Inspired by the issue of induced seismicity in the Groningen field

Induced seismicity refers to seismic events (earthquakes) triggered by human activities. Such events, even when characterized by relatively modest magnitudes, have the potential to jeopardize the safety of individuals, the surrounding environment, and infrastructure. Production from hydrocarbon reservoirs can alter the in-situ stress state, leading to induced seismicity. This is reported in the Groningen field, where substantial gas production caused fault reactivation and subsequent earthquakes. Understanding events in the deep subsurface is crucial to proactively mitigate future seismic occurrences. To understand the causes of induced seismicity, the underlying physics are examined and defined in terms of relevant governing equations and models. This reveals the interconnected nature of fluid depletion, rock deformation, and fault slip. The goal of this study is to develop simulation techniques to solve these equations. Towards this end, firstly, a finite volume embedded-numerical simulation method, called the Smoothed Enhanced Finite Volume method (sEFVM), is developed. This method is revealed to be computationally efficient for reservoir-scale modeling of heavily faulted systems and performed well in comparison to known solutions and other simulators. However, in settings where analytical solutions indicated noncontinuous shear stress profiles, sEFVM accuracy suffers. Recognizing this limitation, a semi-analytical approach is developed, extending analytical expressions to be solved over the sEFVM mesh. This extension allows for more accurate solutions, accommodating complex reservoir and fault geometries. The semi-analytical method is successfully used to estimate the onset of fault nucleation and the magnitude of the seismic moment resulting from depletion. The semi-analytical approach is limited to simulating fault slip up to the point of nucleation. To overcome this constraint, a hybrid method is developed. With appropriate assumptions regarding the post-nucleation state and the use of sEFVM to numerically calculate post-nucleation stresses, the hybrid method can effectively model multi-fault systems in the seismic stage assuming quasi-static behavior. In summary, this research contributes by presenting novel computational frameworks for studying fault reactivation in faulted poroelastic media, offering insights into the complex interactions of the physics at play. The proposed embedded-numerical, semi analytical, and hybrid methods pave the way for further advancements in the field. Applied GeologyReservoir Engineerin

Performance of Potassium Bicarbonate and Calcium Chloride Draw Solutions for Desalination of Saline Water Using Forward Osmosis

Forward osmosis (FO) has recently drawn attention as a promising membrane based method for seawater and brackish water desalination. In this study, we focus on the use of calciun chloride (CaCl2) and potassium bicarbonate (KHCO3) as inorganic salt draw solution candidates due to their appropriate performance in water flux and reverse salt diffusion as well as reasonable cost. The experiments were carried at 25 °C and cross-flow rate of 3 L min−1.  At the same osmotic pressure, the water flux of CaCl2 draw solution tested against deionized feed water, showed 20% higher permeation than KHCO3, which it was attributed to the lower internal concentration polarization (ICP). The reverse diffusion of CaCl2 was found higher than KHCO3 solution which it would be related to the smaller ionic size and the higher permeation of this salt through the membrane. The water flux for both draw solutions against 0.33 M NaCl feed solution was about 2.8 times lower than deionized feed water because of ICP. Higher concentrations of draw solution is required for increasing the water permeation from saline water feed towards the draw side

Smoothed embedded finite-volume method (sEFVM) for modeling contact mechanics in deformable faulted and fractured porous media

A smoothed embedded finite-volume modeling (sEFVM) method is presented for faulted and fractured heterogeneous poroelastic media. The method casts a fully coupled strategy to treat the coupling between fault slip mechanics, deformation mechanics, and fluid flow equations. This ensures the stability and consistency of the simulation results, especially, as the fault slip is implicitly found through an iterative prediction-correction procedure. The computational grid is generated independently for embedded faults and rock matrix. The efficiency is further enhanced by extending the finite-volume discrete space by introducing only one degree of freedom per fault element. The embedded approach can lead to an oscillatory stress field at the fault, which damages the robustness of the implicit slip detection strategy. To resolve this challenge, a smoothed embedded strategy is devised, in which the stress and slip profiles are post processed within the iterative loops by fitting the best curve based on a least-square error criterion. The sEFVM provides locally conservative mass flux and stress fields, on staggered grid. Its performance is further investigated for several proof-of-the-concept test cases, including a multiple fault system in a heterogeneous domain. Results indicate that the method develops a promising approach for field-scale relevant simulation of induced seismicity.Petroleum EngineeringCivil Engineering and Geoscience

Global and regional prevalence of strabismus: a comprehensive systematic review and meta-analysis

Purpose: Despite the importance of information on the prevalence of strabismus, which can be effective in planning preventive and curative services, no study has addressed its prevalence comprehensively. In this study, a systematic search was done to estimate the regional and global prevalence of strabismus in different age and sex groups and factors affecting prevalence heterogeneity. Methods: A comprehensive and systematic search was done in different international databases, including Web of Science, Scopus, PubMed, Embase, etc. to find published articles on the total prevalence of strabismus and the prevalence of exotropia and esotropia. A binomial distribution was used to calculate the prevalence and 95 confidence interval (CI). The Cochran's Q-test and I-2 were applied to evaluate heterogeneity and a random-effects model was used to assess the pooled prevalence. The Begg's test was administered to investigate publication bias and finally, a meta-regression method was applied to determine the factors affecting the heterogeneity among studies. Results: Of 7980 articles, 56 articles with a total sample size of 229,396 were analyzed. Many of these articles (n = 14) were from the Regional Office for the Americas. The estimated of pooled prevalence (95 CI) of any strabismus, exotropia, and esotropia was 1.93 (1.64-2.21), 1.23 (1.00-1.46), and 0.77 (0.59-0.95), respectively. The heterogeneity in prevalence of strabismus and its subtypes according to I-2 was above 95 (p value <.001 for all). Age had a direct effect on heterogeneity in the prevalence of exotropia (b: 3.491; p: 0.002). Moreover, WHO region had a significant direct effect on heterogeneity in the prevalence of strabismus (b: 0.482; p < .001) and esotropia (b: 0.168; p: 0.027), and publication year had a significant direct effect on heterogeneity in the prevalence of exotropia (b: 0.059; p: 0.045). Sample size and publication year did not have any association with strabismus nor with other variables. There was no publication bias according to the Begg's test. Conclusion: The prevalence of strabismus varies widely in the world. As for factors affecting heterogeneity in the prevalence of strabismus, the results showed that age affected heterogeneity in the prevalence of exotropia, WHO region affected heterogeneity in the prevalence of strabismus and esotropia, and publication year affected heterogeneity in the prevalence of exotropia. Information about the global prevalence of strabismus can help health care planners design interventions and prioritize resource allocation