Editorial: Developing Successful Neuroprotective Treatments for TBI: Translational Approaches, Novel Directions, Opportunities and Challenges

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Find the Words: Helping Students Develop Better Clinical Skills

On March 12, 2019, Katherine Shear, Marion E. Kenworthy Professor of Psychiatry in Social Work, Kristin Garay, and Matthea Marquart will present at the Columbia University Center for Teaching and Learning's 2019 Celebration of Teaching and Learning Symposium, as part of the Interactive Showcase of Teaching Innovations. Their poster, "Find the Words: Helping Students Develop Better Clinical Skills," will share the teaching innovation developed during Professor Shear's Fall 2018 online Introduction to Grief Therapy course, which she redesigned with a 2018 Teaching & Learning Grant for Hybrid Learning Course Redesign and Delivery from the Office of the Provost

Ecstasy Exposure & Gender: Examining Components of Verbal Memory Functioning

Objective: Studies have demonstrated verbal memory deficits associated with past year ecstasy use, although specific underlying components of these deficits are less understood. Further, prior research suggests potential gender differences in ecstasy-induced serotonergic changes. Therefore, the current study investigated whether gender moderated the relationship between ecstasy exposure and components of verbal memory after controlling for polydrug use and confounding variables. Method Data were collected from 65 polydrug users with a wide range of ecstasy exposure (ages 18–35; 48 ecstasy and 17 marijuana users; 0–2310 ecstasy tablets). Participants completed a verbal learning and memory task, psychological questionnaires, and a drug use interview. Results: Increased past year ecstasy exposure predicted poorer short and long delayed free and cued recalls, retention, and recall discrimination. Male ecstasy users were more susceptible to dose-dependent deficits in retention than female users. Conclusion: Past year ecstasy consumption was associated with verbal memory retrieval, retention, and discrimination deficits in a dose-dependent manner in a sample of healthy young adult polydrug users. Male ecstasy users were at particular risk for deficits in retention following a long delay. Gender difference may be reflective of different patterns of polydrug use as well as increased hippocampal sensitivity. Future research examining neuronal correlates of verbal memory deficits in ecstasy users are needed

On the evolution of decoys in plant immune systems

The Guard-Guardee model for plant immunity describes how resistance proteins (guards) in host cells monitor host target proteins (guardees) that are manipulated by pathogen effector proteins. A recently suggested extension of this model includes decoys, which are duplicated copies of guardee proteins, and which have the sole function to attract the effector and, when modified by the effector, trigger the plant immune response. Here we present a proof-of-principle model for the functioning of decoys in plant immunity, quantitatively developing this experimentally-derived concept. Our model links the basic cellular chemistry to the outcomes of pathogen infection and resulting fitness costs for the host. In particular, the model allows identification of conditions under which it is optimal for decoys to act as triggers for the plant immune response, and of conditions under which it is optimal for decoys to act as sinks that bind the pathogen effectors but do not trigger an immune response.Comment: 15 pages, 6 figure

Sensing the heat: Climate change vulnerability and foreign direct investment inflows

We investigate whether climate change vulnerability determines foreign direct investment (FDI) inflows. We reason that multinational firms foresee a higher climate change vulnerability of host-country a locational disadvantage while making FDI allocation decisions. Utilizing annual data from 152 countries spanning the period 1996–2019 and employing the panel pooled ordinary least square regressions, we evidence that FDI inflows are lower in countries more vulnerable to climate change. We also observe that FDI inflows are only sensitive to climate-related risks in high- and middle-income countries, but not in low-income countries where the market size is a primary driver of FDI inflows. Moreover, we also find that host countries may weaken the adverse effects of climate change vulnerability on FDI inflows by strengthening the economic, institutional, and social environment

Sparse Distribution Pattern Of Some Plant Species In Two Afromontane Rain Forests Of The Eastern Arc Mountains Of Tanzania

Mountain forests play major roles in biodiversity; containing many endemics and species of conservation concern. The diversity and distribution patterns of plants in mountain ecosystems are influenced by various environmental and anthropogenic factors that exhibit heterogeneity over space and time. This study analysed species diversity and distribution patterns on two afromontane rain forests of the eastern Arc Mountains of Tanzania in the west Usambaras and Ulugurus to assess any possible threats to biodiversity conservation in this region. A hundred sample plots (0.02 ha) were established on each of the two mountain ranges in such a way as to cover as much variations as possible from valley bottoms to ridge tops. The analysis was based on species importance values computed from the average of the relative basal area and relative density as well as species frequency. Using different diversity indices, the study showed that the mountains have high species diversity. Eighteen endemic species were identified in the Usambaras and thirty-two in the Ulugurus. These endemics are fairly shared between the two mountains and other mountain massifs of the Eastern Arc. Based on our analysis of species distribution, it was found that the proportion of sparsely (rarely) distributed species was over 30% and 49% for the woody species and total vascular plants, respectively. These findings are important in alerting on possible decline of biodiversity in the region and prompting the development of policies to address rare, threatened, and endangered plant species, which are non-existence in Tanzania. We suggest further surveys in the forests of the Eastern Arc Mountains to determine whether the apparently sparse distribution of some species may be found in reasonable abundances elsewhere and quantify the manner and type of use of the forest resources by surrounding local communities to determine their possible impacts on species distribution. TJFNC Vol. 75 2004: pp. 74-9