A 2D computational parametric analysis of the sheltering effect of fences on a railway vehicle standing on a bridge and experiencing crosswinds

In a crosswind scenario, the risk of high-speed trains overturning increases when they run on viaducts since the aerodynamic loads are higher than on the ground. In order to increase safety, vehicles are sheltered by fences that are installed on the viaduct to reduce the loads experienced by the train. Windbreaks can be designed to have different heights, and with or without eaves on the top. In this paper, a parametric study with a total of 12 fence designs was carried out using a two-dimensional model of a train standing on a viaduct. To asses the relative effectiveness of sheltering devices, tests were done in a wind tunnel with a scaled model at a Reynolds number of 1 × 105, and the train’s aerodynamic coefficients were measured. Experimental results were compared with those predicted by Unsteady Reynolds-averaged Navier-Stokes (URANS) simulations of flow, showing that a computational model is able to satisfactorily predict the trend of the aerodynamic coefficients. In a second set of tests, the Reynolds number was increased to 12 × 106 (at a free flow air velocity of 30 m/s) in order to simulate strong wind conditions. The aerodynamic coefficients showed a similar trend for both Reynolds numbers; however, their numerical value changed enough to indicate that simulations at the lower Reynolds number do not provide all required information. Furthermore, the variation of coefficients in the simulations allowed an explanation of how fences modified the flow around the vehicle to be proposed. This made it clear why increasing fence height reduced all the coefficients but adding an eave had an effect mainly on the lift force coefficient. Finally, by analysing the time signals it was possible to clarify the influence of the Reynolds number on the peak-to-peak amplitude, the time period and the Strouhal number

A 2D computational parametric analysis of the sheltering effect of fences on a railway vehicle standing on a bridge and experiencing crosswinds

In a crosswind scenario, the risk of high-speed trains overturning increases when they run on viaducts since the aerodynamic loads are higher than on the ground. In order to increase safety, vehicles are sheltered by fences that are installed on the viaduct to reduce the loads experienced by the train. Windbreaks can be designed to have different heights, and with or without eaves on the top. In this paper, a parametric study with a total of 12 fence designs was carried out using a two-dimensional model of a train standing on a viaduct. To asses the relative effectiveness of sheltering devices, tests were done in a wind tunnel with a scaled model at a Reynolds number of 1 × 105, and the train’s aerodynamic coefficients were measured. Experimental results were compared with those predicted by Unsteady Reynolds-averaged Navier-Stokes (URANS) simulations of flow, showing that a computational model is able to satisfactorily predict the trend of the aerodynamic coefficients. In a second set of tests, the Reynolds number was increased to 12 × 106 (at a free flow air velocity of 30 m/s) in order to simulate strong wind conditions. The aerodynamic coefficients showed a similar trend for both Reynolds numbers; however, their numerical value changed enough to indicate that simulations at the lower Reynolds number do not provide all required information. Furthermore, the variation of coefficients in the simulations allowed an explanation of how fences modified the flow around the vehicle to be proposed. This made it clear why increasing fence height reduced all the coefficients but adding an eave had an effect mainly on the lift force coefficient. Finally, by analysing the time signals it was possible to clarify the influence of the Reynolds number on the peak-to-peak amplitude, the time period and the Strouhal number

Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing Ebola virus immune evasion

Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis. A high-throughput screening assay, developed to identify compounds that either inhibit or bypass VP35 IFN-antagonist function, identified five DNA intercalators as reproducible hits from a library of bioactive compounds. Four, including doxorubicin and daunorubicin, are anthracycline antibiotics that inhibit topoisomerase II and are used clinically as chemotherapeutic drugs. These compounds were demonstrated to induce IFN responses in an ATM kinase-dependent manner and to also trigger the DNA-sensing cGAS-STING pathway of IFN induction. These compounds also suppress EBOV replication in vitro and induce IFN in the presence of IFN-antagonist proteins from multiple negative-sense RNA viruses. These findings provide new insights into signaling pathways activated by important chemotherapy drugs and identify a novel therapeutic approach for IFN induction that may be exploited to inhibit RNA virus replication

An algorithm to obtain global solutions of the double confluent Heun equation

A procedure is proposed to construct solutions of the double confluent Heun equation with a determinate behaviour at the singular points. The connection factors are expressed as quotients of Wronskians of the involved solutions. Asymptotic expansions are used in the computation of those Wronskians. The feasibility of the method is shown in an example, namely, the Schroedinger equation with a quasi-exactly-solvable potential

A report on the nonlinear squeezed states and their non-classical properties of a generalized isotonic oscillator

We construct nonlinear squeezed states of a generalized isotonic oscillator potential. We demonstrate the non-existence of dual counterpart of nonlinear squeezed states in this system. We investigate statistical properties exhibited by the squeezed states, in particular Mandel's parameter, second-order correlation function, photon number distributions and parameter $A_3$ in detail. We also examine the quadrature and amplitude-squared squeezing effects. Finally, we derive expression for the $s$-parameterized quasi-probability distribution function of these states. All these information about the system are new to the literature.Comment: Accepted for publication in J. Phys. A: Math. Theo

Basin Effects in Strong Ground Motion: A Case Study from the 2015 Gorkha, Nepal Earthquake

The term "basin effects" refers to entrapment and reverberation of earthquake waves in soft sedimentary deposits underlain by concave basement rock structures. Basin effects can significantly affect the amplitude, frequency and duration of strong ground motion, while the cone-like geometry of the basin edges gives rise to large amplitude surface waves through seismic wave diffraction and energy focusing, a well-known characteristic of basin effects. In this research, we study the role of basin effects in the mainshock ground motion data recorded at the Kathmandu basin, Nepal during the 2015 Mw7.8 Gorkha earthquake sequence. We specifically try to understand the source of the unusual low frequency reverberating pulse that appeared systematically across the basin, and the unexpected depletion of the ground surface motions from high frequency components, especially away from the basin edges. In order to do that we study the response of a 2D cross section of Kathmandu basin subjected to vertically propagating plane SV waves. Despite the scarcity of geotechnical information and of strong ground motion recordings, we show that an idealized plane-strain elastic model with a simplified layered velocity structure can capture surprisingly well the low frequency components of the basin ground response. We finally couple the 2D elastic simulation with a 1D nonlinear analysis of the shallow basin sediments. The 1D nonlinear approximation shows improved performance over a larger frequency range relative to the first order approximation of a 2D elastic layered basin response.Comment: Geotechnical Earthquake Engineering and Soil Dynamics V, Austin, Texas (2018

Incidencia de bajas dosis de N, P Y S sobre el rendimiento de cebolla Valenciana (Variedad sintética 14)

During the growing season of 1988/89 a trial was held in the large vegetable experimental field at the Agronomy Faculty of the University of La Pampa, under square latin design 5 x 5. Fertilizers of N, P and S were applied to the Synthetical Variety 14 of Valenciana onion. The main objective was to determine the influence of N and its interaction of P and S upon final yield. The fertilizars were: Urea; H(NH4)2 PO4 + Urea; (NH4)2 SO4 +Urea; (NH4)2 SO4 +H(NH4)2 PO4 +Urea and tester. All doses were adjust in such manner all plots had the same amount on N, in order to compare its effects. Highly significantive differences were observed between treatments. With respect to entire plant's weight expose to the air, T2 overcame significantly to Tc and T1. Calcium, Magnesium, phosphorus, crude protein and water contens were analyzed in lab and the results are considered normal. According to the results obtained in the current trial, it might be suggested to fertilize onion with compounds including N and Pinto their composition.En el ciclo 1988/89 se realizó en la Huerta Experimental de la Fac. de Agron. de la UNLPam, un ensayo en cuadrado latino 5 x 5, de aplicaci6n de fertilizantes con N, P Y S, en cultivo de "cebollas" variedad sintética 14. El objetivo fue constatar la incidencia del N y su interacción con el P y S sobre el rendimiento del cultivo. Los fertilizantes empleados fueron: Urea; H (NH4)2 PO4 +Urea; (NH4) 2 SO4 +Urea; (NH4) SO4 +H(NH4)2 PO4 +Urea y testigo. En todos los casos las dosis se ajustaron de tal manera que, todas las parcelas en que se aplicaron fertilizantes, vieran la misma cantidad de N para poder comparar sus efectos. En cuanto a los rendimientos de los tratamientos si se observaron diferencias significativas". Respecto al peso planta entera oreada, T2 superó significativamente a TO y T1. También se analizó en laboratorio al contenido de calcio, magnesio, fósforo, proteína cruda y agua siendo sus valores normales. Sobre la base de los resultados obtenidos en el presente ensayo se aconsejaría fertilizar la cebolla con compuestos que tengan N y P en su composición

Spiked oscillators: exact solution

A procedure to obtain the eigenenergies and eigenfunctions of a quantum spiked oscillator is presented. The originality of the method lies in an adequate use of asymptotic expansions of Wronskians of algebraic solutions of the Schroedinger equation. The procedure is applied to three familiar examples of spiked oscillators