Stability and electronic structure of the complex K2_2PtCl6_6 structure-type hydrides

The stability and bonding of the ternary complex K$_2$PtCl$_6$ structure hydrides is discussed using first principles density functional calculations. The cohesion is dominated by ionic contributions, but ligand field effects are important, and are responsible for the 18-electron rule. Similarities to oxides are discussed in terms of the electronic structure. However, phonon calculations for Sr$_2$RuH$_6$ also show differences, particularly in the polarizability of the RuH$_6$ octahedra. Nevertheless, the yet to be made compounds Pb$_2$RuH$_6$ and Be$_2$FeH$_6$ are possible ferroelectrics. The electronic structure and magnetic properties of the decomposition product, FeBe$_2$ are reported. Implications of the results for H storage are discussed

Reconstitution of dynein transport to the microtubule plus end by kinesin

Cytoplasmic dynein powers intracellular movement of cargo toward the microtubule minus end. The first step in a variety of dynein transport events is the targeting of dynein to the dynamic microtubule plus end, but the molecular mechanism underlying this spatial regulation is not understood. Here, we reconstitute dynein plus-end transport using purified proteins from S. cerevisiae and dissect the mechanism using single-molecule microscopy. We find that two proteins–homologs of Lis1 and Clip170–are sufficient to couple dynein to Kip2, a plus-end-directed kinesin. Dynein is transported to the plus end by Kip2, but is not a passive passenger, resisting its own plus-end-directed motion. Two microtubule-associated proteins, homologs of Clip170 and EB1, act as processivity factors for Kip2, helping it overcome dynein's intrinsic minus-end-directed motility. This reveals how a minimal system of proteins transports a molecular motor to the start of its track. DOI: http://dx.doi.org/10.7554/eLife.02641.00

Giant Electroresistance in Ferroelectric Tunnel Junctions

The interplay between the electron transport in metal/ferroelectric/metal junctions with ultrathin ferroelectric barriers and the polarization state of a barrier is investigated. Using a model which takes into account screening of polarization charges in metallic electrodes and direct quantum tunneling across a ferroelectric barrier we calculate the change in the tunneling conductance associated with the polarization switching. We find the conductance change of a few orders of magnitude for metallic electrodes with significantly different screening lengths. This giant electroresistance effect is the consequence of a different potential profile seen by transport electrons for the two opposite polarization orientations.Comment: 4 page

Characterization of high-temperature PbTe p-n junctions prepared by thermal diffusion and by ion-implantation

We describe here the characteristics of two types of high-quality PbTe p-n-junctions, prepared in this work: (1) by thermal diffusion of In4Te3 gas (TDJ), and (2) by ion implantation (implanted junction, IJ) of In (In-IJ) and Zn (Zn-IJ). The results, as presented here, demonstrate the high quality of these PbTe diodes. Capacitance-voltage and current-voltage characteristics have been measured. The measurements were carried out over a temperature range from ~ 10 K to ~ 180 K. The latter was the highest temperature, where the diode still demonstrated rectifying properties. This maximum operating temperature is higher than any of the earlier reported results. The saturation current density, J0, in both diode types, was ~ 10^-5 A/cm2 at 80 K, while at 180 K J0 ~ 10^-1 A/cm2 in TDJ and ~ 1 A/cm2 in both ion-implanted junctions. At 80 K the reverse current started to increase markedly at a bias of ~ 400 mV for TDJ, and at ~550 mV for IJ. The ideality factor n was about 1.5-2 for both diode types at 80 K. The analysis of the C-V plots shows that the junctions in both diode types are linearly graded. The analysis of the C-V plots allows also determining the height of the junction barrier, the concentrations and the concentration gradient of the impurities, and the temperature dependence of the static dielectric constant. The zero-bias-resistance x area products (R0Ae) at 80 K are: 850 OHMcm2 for TDJ, 250 OHMcm2 for In-IJ, and ~ 80 OHMcm2 for Zn-IJ, while at 180 K R0Ae ~ 0.38 OHMcm2 for TDJ, and ~ 0.1 OHMcm2 for IJ. The estimated detectivity is: D* ~ 10^10 cmHz^(1/2)/W up to T=140 K, determined mainly by background radiation, while at T=180 K, D* decreases to 108-107 cmHz^(1/2)/W, and is determined by the Johnson noise

Neuroinflammation and white matter alterations in obesity assessed by Diffusion Basis Spectrum Imaging

Human obesity is associated with low-grade chronic systemic inflammation, alterations in brain structure and function, and cognitive impairment. Rodent models of obesity show that high-calorie diets cause brain inflammation (neuroinflammation) in multiple regions, including the hippocampus, and impairments in hippocampal-dependent memory tasks. To determine if similar effects exist in humans with obesity, we applied Diffusion Basis Spectrum Imaging (DBSI) to evaluate neuroinflammation and axonal integrity. We examined diffusion-weighted magnetic resonance imaging (MRI) data in two independent cohorts of obese and non-obese individuals (Cohort 1: 25 obese/21 non-obese; Cohort 2: 18 obese/41 non-obese). We applied Tract-based Spatial Statistics (TBSS) to allow whole-brain white matter (WM) analyses and compare DBSI-derived isotropic and anisotropic diffusion measures between the obese and non-obese groups. In both cohorts, the obese group had significantly greater DBSI-derived restricted fraction (DBSI-RF; an indicator of neuroinflammation-related cellularity), and significantly lower DBSI-derived fiber fraction (DBSI-FF; an indicator of apparent axonal density) in several WM tracts (all correcte

Hybrid paramagnon phonon modes at elevated temperatures in EuTiO3

EuTiO3 (ETO) has recently experienced an enormous revival of interest because of its possible multiferroic properties which are currently in the focus of research. Unfortunately ETO is an unlikely candidate for enlarged multifunctionality since the mode softening - typical for ferroelectrics - remains incomplete, and the antiferromagnetic properties appear at 5.5K only. However, a strong coupling between lattice and Eu spins exists and leads to the appearance of a magnon-phonon-hybrid mode at elevated temperatures as evidenced by electron paramagnetic resonance (EPR), muon spin rotation ({\mu}SR) experiments and model predictions based on a coupled spin-polarizability Hamiltonian. This novel finding supports the notion of strong magneto-dielectric (MD) effects being realized in ETO and opens new strategies in material design and technological applications.Comment: 9 pages, 4 figure

Ocorrência dos genótipos g e p de rotavírus do grupo a em bezerros de rebanhos de corte no estado de São Paulo, Brasil.

Foi determinada a ocorrência de rotavírus do grupo A e a caracterização molecular G e P de estirpes detectadas em bezerros de rebanhos de corte em propriedades rurais do Estado de São Paulo, Brasil. Foram analisadas amostras de fezes de 649 bezerros de 14 rebanhos de corte com idade entre 1 e 60 dias, independentemente da manifestação clínica de diarréia, colhidas de julho de 2003 a julho de 2004. Por meio das técnicas de ELISA e de eletroforese em gel de poliacrilamida (PAGE), determinou-se a ocorrência de rotavírus do grupo A em 64,3% (09/14) dos rebanhos e em 6,2% (40/649) dos animais. A maior freqüência de infecção foi detectada em animais com idade entre 16 e 30 dias (10,5%). Foram diagnosticados bezerros infectados por rotavírus tanto em animais com sinais clínicos de diarréia (25,8%; 22/85) quanto naqueles assintomáticos (3,2%; 18/ 564), existindo, porém, uma correlação entre a presença da infecção e a manifestação clínica da diarréia (p < 0,01). A análise do perfil do genoma do rotavírus por PAGE identificou sete eletroferótipos distintos, indicando grande diversidade genômica dos rotavírus na região estudada. A genotipagem pela reação em cadeia da polimerase (RT-PCR) das amostras de rotavírus revelou que as estirpes circulantes nos rebanhos eram G6P[5], G6P[11], G6P[5]P[11] e G10P[11]