High resolution measurements of density structures in the Jovian plasma sheet

A recent effort to digitize the plasma density by using the low frequency cutoff of trapped continuum radiation in the vicinity of the Jovian plasma sheet has revealed the existence of sharply defined density structures in the plasma sheet. These structures typically have a plasma density which is relatively constant but of order 50 percent greater or less than in the surrounding plasma. At the boundaries of these structures, the transitions from low to high density occur on time scales of about ten seconds, which correspond to spatial dimensions on the order of a few ion Larmor radii. The structures themselves last for intervals from less than a minute to more than five minutes, corresponding to size scales from a fraction of a Jovian radius to more than a Jovian radius, depending of the velocity of the structure relative to the spacecraft. In view of the importance of near corotation plasma flows, these structures are likely to be limited in both the longitudinal and radial dimensions and, therefore, could represent flux tubes with greatly varying plasma content. These observations are presented as among the first to directly address the theoretically proposed interchange instability

Micron-Sized Dust Particles Detected in the Outer Solar System by the Voyager 1 and 2 Plasma Wave Instruments

During the Voyager 1 and 2 flybys of the outer planets it has been demonstrated that the plasma wave instrument can detect small dust particles striking the spacecraft. In this paper, we examine the Voyager plasma wave data for dust impacts in the interplanetary medium at heliocentric radial distances ranging from 6 to 60 astronomical units (AU). The results show that a small but persistent level of dust impacts exists out to at least 30 to 50 AU. The average number density of these particles is about 2 x 10(exp -8)/cu m, and the average mass of the impacting particles is believed to be a few times 10(exp -11) g, which corresponds to particle diameters in the micron range. Possible sources of these particles are planets, moons, asteroids, comets, and the interstellar medium. Of these, comets appear to be the most likely source. The number densities are only weakly dependent on ecliptic latitude, which indicates that the particles probably do not originate from planets, moons, or asteroids. Comparisons with interstellar dust fluxes measured in the inner regions of the solar system by the Ulysses spacecraft indicate that the particles are not of interstellar origin

Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients

10.1371/journal.pone.0054522PLoS ONE81

Australian health care providers' views on opt-out HIV testing

Background: Opt-out HIV testing is a novel concept in Australia. In the opt-out approach, health care providers (HCPs) routinely test patients for HIV unless they explicitly decline or defer. Opt-out HIV testing is only performed with the patients' consent, but pre-test counselling is abbreviated. Australian national testing guidelines do not currently recommend opt-out HIV testing for the general population. Non-traditional approaches to HIV testing (such as opt-out) could identify HIV infections and facilitate earlier treatment, which is particularly important now that HIV is a chronic, manageable disease. Our aim was to explore HCPs' attitudes toward opt-out HIV testing in an Australian context, to further understanding of its acceptability and feasibility. Methods: In this qualitative study, we used purposeful sampling to recruit HCPs who were likely to have experience with HIV testing in Western Australia. We interviewed them using a semi-structured guide and used content analysis as per Graneheim to code the data. Codes were then merged into subcategories and finally themes that unified the underlying concepts. We refined these themes through discussion among the research team. Results: Twenty four HCPs participated. Eleven participants had a questioning attitude toward opt-out HIV testing, while eleven favoured the approach. The remaining two participants had more nuanced perspectives that incorporated some characteristics of the questioning and favouring attitudes. Participants' views about opt-out HIV testing largely fell into two contrasting themes: normalisation and routinisation versus exceptionalism; and a need for proof versus openness to new approaches. Conclusion: Most HCPs in this study had dichotomous attitudes toward opt-out HIV testing, reflecting contrasting analytical styles. While some HCPs viewed it favourably, with the perceived benefits outweighing the perceived costs, others preferred to have evidence of efficacy and cost-effectiveness

Role of endotoxin in alterations of hepatic drug metabolism by diphtheria and tetanus toxoids and pertussis vaccine adsorbed

Administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed (DTP vaccine) or endotoxin (LPS) resulted in marked alterations in hepatic drug-metabolizing enzymes in endotoxin-responsive (R) and non-endotoxin-responsive (NR) mice. A single human dose (0.5 ml) of DTP vaccine increased hexobarbital-induced sleep times to 1.6- to 1.8-fold above those of controls in both strains of mice. This effect persisted for 7 days. In contrast, Bordetella pertussis LPS-treated mice showed an increase at 1 day (3.0-fold for R mice and 1.5-fold for NR mice), which returned to control levels by day 7. Furthermore, cytochrome P-450 levels were decreased 30 to 40% 24 h after DTP vaccine administration in both R and NR mice, while after LPS administration they were decreased 30% in R mice and less than 10% in NR mice. Both spleen and liver weights of R and NR mice were increased 7 to 14 days following DTP vaccine administration. However, LPS treatment had no apparent effect on liver weights, and spleen weights of R mice were elevated from days 3 to 7. Histopathologic tissue examination showed random, multifocal inflammation with hepatocyte necrosis after DTP vaccine administration to both R and NR mice and an absence of lesions in LPS-treated mice. Premixing LPS with polymyxin eliminated the increased sleep times, but premixing DTP vaccine with polymyxin did not affect the increased sleep times. Levels of tumor necrosis factor and interleukin-6 in plasma of R mice were markedly increased after DTP and LPS treatment, while NR mice had reduced increases. These results suggest that LPS contributes to the alterations in R and NR mice seen within the first 24 h of vaccine administration but that it is not likely to contribute to the effects observed at later time points.</jats:p