Creep of a fracture line in paper peeling

The slow motion of a crack line is studied via an experiment in which sheets of paper are split into two halves in a ``peel-in-nip'' (PIN) geometry under a constant load, in creep. The velocity-force relation is exponential. The dynamics of the fracture line exhibits intermittency, or avalanches, which are studied using acoustic emission. The energy statistics is a power-law, with the exponent $\beta \sim 1.8 \pm 0.1$. Both the waiting times between subsequent events and the displacement of the fracture line imply complicated stick-slip dynamics. We discuss the correspondence to tensile PIN tests and other similar experiments on in-plane fracture and the theory of creep for elastic manifolds

Network-aware design-space exploration of a power-efficient embedded application

The paper presents the design and multi-parameter optimization of a networked embedded application for the health-care domain. Several hardware, software, and application parameters, such as clock frequency, sensor sampling rate, data packet rate, are tuned at design- and run-time according to application specifications and operating conditions to optimize hardware requirements, packet loss, power consumption. Experimental results show that further power efficiency can be achieved by considering also communication aspects during design space exploratio

Transient inverse energy cascade in free surface turbulence

We study the statistics of free-surface turbulence at large Reynolds numbers produced by direct numerical simulations in a fluid layer at different thickness with fixed characteristic forcing scale. We observe the production of a transient inverse cascade, with a duration which depends on the thickness of the layer, followed by a transition to three-dimensional turbulence initially produced close to the bottom, no-slip boundary. By switching off the forcing, we study the decaying turbulent regime and we find that it cannot be described by an exponential law. Our results show that boundary conditions play a fundamental role in the nature of turbulence produced in thin layers and give limits on the conditions to produce a two-dimensional phenomenology.Comment: 9 pages, 8 figure

Low Reynolds number turbulent flows over elastic walls

We study the laminar and turbulent channel flow over a viscous hyper-elastic wall and show that it is possible to sustain an unsteady chaotic turbulent-like flow at any Reynolds number by properly choosing the wall elastic modulus. We propose a physical explanation for this effect by evaluating the shear stress and the turbulent kinetic energy budget in the fluid and elastic layer. We vary the bulk Reynolds number from 2800 to 10 and identify two distinct mechanisms for turbulence production. At moderate and high Reynolds numbers, turbulent fluctuations activate the wall oscillations, which, in turn, amplify the turbulent Reynolds stresses in the fluid. At very low Reynolds number, the only production term is due to the energy input from the elastic wall, which increases with the wall elasticity. This mechanism may be exploited to passively enhance mixing in microfluidic devices

Current treatment approaches in CML.

Take home messages Five tyrosine kinase inhibitors are available, the treatment strategy is still challenging. Baseline risk, comorbidities, and patient and physician expectations play a pivotal role. Treatment-free remission is a new opportunity

Design and validation of a hardware-in-the-loop test bench for evaluating the performance of an active mass damper

The purpose of this study is to propose an innovative solution for evaluating the performance of a full-scale Active Mass Damper (AMD). The AMD adopted is a custom hydraulic actuator, developed for active control of existing buildings against earthquakes. For vibration control, a sky-hook algorithm was implemented. Its characteristics ensure good robustness, which is fundamental in structural engineering since buildings are subjected to significant variation in dynamic properties in presence of damage or ambient conditions. A Hardware-In-the-Loop (HIL) test bench was specifically designed to simulate the actual working condition of the anti-seismic system. The HIL setup consists of a shaking table moved by a hydraulic actuator in accordance with the roof's displacement, evaluated using a structural numerical model of the building to which the AMD is fixed. The presence of two distinct active systems (HIL and AMD) could generate control issues; therefore, a Triple Variable Control logic was introduced to reduce the interaction delay. The effectiveness of the proposed AMD is validated comparing the roof's displacement in an uncontrolled structure with that in a controlled one. Also, the robustness of the control algorithm was verified using a non-linear structural model and applying seismic excitation at different intensities

Role of barriers in the airborne spread of virus-containing droplets: A study based on high-resolution direct numerical simulations

State-of-the-art direct numerical simulations are exploited to study the role of barriers on the airborne spread of virus-containing droplets. Our study is motivated by recent findings pointing to the key role of turbulence in dictating the final fate of virus-containing droplets in violent human exhalations. Here, all active scales of motion have been explicitly taken into account, including their interplay with the droplet evaporation process occurring once droplets are emitted in a drier ambient air, and accounting for the time-varying droplet inertia due to the water loss via evaporation. We show that barriers commonly used to mitigate the airborne spread of the virus cause nontrivial dynamical effects influencing the final reach of the virus-containing droplets, not always being beneficial to this aim. These conclusions do depend on the relative humidity of the ambient condition, and in particular whether the ambient humidity is above or below the so-called efflorescence relative humidity. Our findings provide a physically based answer to the question on how effective barriers are to protect people from airborne virus transmission in indoor environments

Therapeutic potential of endothelial colony‐forming cells in ischemic disease: Strategies to improve their regenerative efficacy

Cardiovascular disease (CVD) comprises a range of major clinical cardiac and circulatory diseases, which produce immense health and economic burdens worldwide. Currently, vascular regenerative surgery represents the most employed therapeutic option to treat ischemic disorders, even though not all the patients are amenable to surgical revascularization. Therefore, more efficient therapeutic approaches are urgently required to promote neovascularization. Therapeutic angiogenesis represents an emerging strategy that aims at reconstructing the damaged vascular network by stimulating local angiogenesis and/or promoting de novo blood vessel formation according to a process known as vasculogenesis. In turn, circulating endothelial colony‐forming cells (ECFCs) represent truly endothelial precursors, which display high clonogenic potential and have the documented ability to originate de novo blood vessels in vivo. Therefore, ECFCs are regarded as the most promising cellular candidate to promote therapeutic angiogenesis in patients suffering from CVD. The current briefly summarizes the available information about the origin and characterization of ECFCs and then widely illustrates the preclinical studies that assessed their regenerative efficacy in a variety of ischemic disorders, including acute myocardial infarction, peripheral artery disease, ischemic brain disease, and retinopathy. Then, we describe the most common pharmacological, genetic, and epigenetic strategies employed to enhance the vasoreparative potential of autologous ECFCs by manipulating crucial pro‐angiogenic signaling pathways, e.g., extracellular‐signal regulated kinase/Akt, phosphoinositide 3‐kinase, and Ca2+ signaling. We conclude by discussing the possibility of targeting circulating ECFCs to rescue their dysfunctional phenotype and promote neovascularization in the presence of CVD