Kaluza-Klein Type Cosmological Model of the Universe with Inhomogeneous Equation of State

In this paper we study Kaluza-Klein type cosmological model of the universe filled with an ideal fluid obeying an inhomogeneous equation of state depending on time. It is shown that there appears a quasi-periodic universe, which repeats the cycles of phantom type space acceleration

Benign struma ovarii-a rare monodermal ovarian teratoma-a case report

Struma ovarii is a rare ovarian tumour, first described in 1889 by Boettlin. It is defined by the presence of thyroid tissue comprising of >50% of overall mass. It comprises 1% of all ovarian tumours and 2-5% of all ovarian teratomas. Preoperative diagnosis of struma ovarii is difficult because symptoms, clinical presentation and ultrasound are often similar to that of ovarian carcinoma. Hence most of the patients are diagnosed post operatively. Most cases of strum aovarii are benign and can be treated by excision of the ovary or by unilateral salpingo-oophorectomy. In a small number of cases, there are complications, the most important being the development of malignancy or ascites associated with pleural effusion producing a pseudo-Meigs' syndrome. This is a case of struma ovary presented with features of pseudo-Meig’s syndrome. A 68 year old post-menopausal woman presented with acute abdomen and respiratory distress with an ultrasound diagnosis of ovarian torsion, ascites and pleural effusion and found to have atrial thrombus on evaluation. She had undergone staging laparotomy, TAH+ BSO, omental biopsy and peritoneal fluid cytology. Histopathology revealed predominantly benign and mature colloid filled thyroid follicles of varying sizes lined by cuboidal epithelium surrounded by lymphocytic infiltrate and congested blood vessels, which was suggestive of struma ovary.

FIBRINOLYTIC ENZYME FROM BACILLUS AMYLOLIQUEFACIENS: OPTIMISATION AND SCALE UP STUDIES

Objective: This research work was carried out to identify a potent microorganism, which produced the fibrinolytic enzyme and to optimise the media and growth parameters to achieve the maximal enzyme production for commercial application. Methods: Microorganisms were isolated from different sources and assayed for fibrinolytic activity. The shortlisted cultures after preliminary screening (casein hydrolysis, blood plate assay and blood clot dissolution) were identified using 16S rRNA amplification method. The media and growth parameters were optimized to achieve the maximal enzyme activity. In-silico studies were carried out to identify the activators and inhibitors of the enzyme. Results: Two species of Bacillus, namely, Bacillus amyloliquefaciens and Bacillus licheniformis, isolated from spoilt milk and soy flour, respectively, exhibited fibrinolytic activity. In the laboratory scale studies, of these two cultures, B. amyloliquefaciens produced the Fibrinolytic enzyme in higher quantities, 28.98 FU/mL, compared to 26.63 FU/mL in B. licheniformis. The maximal activities were obtained after 72 h. The optimum conditions at laboratory scale for the maximal production of the fibrinolytic enzyme were: pH 7.2, temperature 37 C and agitation 200 rpm. When scale up studies with B. amyloliquefaciens in a 7 L Fermentor were undertaken. The maximal activity obtained was 55.60 FU/mL in 72 h, compared to that of 28.98 FU/mL in shake flask studies. The molecular weight of the enzyme was estimated to be about 38 kDa. In in-silico studies, it was observed that PMSF inhibited the fibrinolytic activity, thereby, confirming this fibrinolytic enzyme is a serine protease (Nattokinase). Conclusion: The enzyme had exhibited excellent blood clot dissolving property and therefore may be considered for further scale up and commercial exploitation

A Study of Reproductive Morbidities among Women Reporting to Primary and Tertiary Care Centres in and around Delhi

Purpose: To assess reproductive morbidities among women reporting to a tertiary and a primary health centres in and around Delhi, India. Methods: 581 women (388 were from Safdarjung Hospital and 193 from the Primary Health Centre in Najafgarh) of all age groups who attended the gynecological out-patient departments at both centres were interviewed using a structured questionnaire comprising of questions relating to general socio-demographic information and the reasons for coming to the centre and examined. These were categorized into gynecological, obstetrical or contraceptive after obtaining a detailed history. Results: The frequency of reproductive morbidities in the present study was observed to be quite high with gynecological conditions being the most common (88.64%), followed by obstetric (65.93%) and contraceptive (11.53%) morbidities. Conclusion: Gynaecological conditions were the major reasons while the women visited the healthcare facilities. Early identification of RTIs and other types of morbidities needs to be encouraged through regular check-ups. The antenatal clinics also need to be strengthened in order to ensure better obstetric health care.Keywords: Contraceptive, Gynecology, Morbidity, Obstetrics, RTI

The clinical study of vaginal birth after caesarean section

Background: VBAC has reduced the rate of repeat caesarean section in modern medicine. VBAC-TOL is successful in 60-80% of acceptable candidates if applied to all patients presenting with prior caesarean procedure (8.2-8.5%), there is potential to increase the overall vaginal delivery rate by 5%. Though the safety of VBAC in carefully selected patients have been demonstrated in several studies, controversy continues over when to advise patients who had caesarean section to undergo TOL. The purpose of current study was to know the success of VBAC, to know the maternal morbidity and mortality and foetal outcome in VBAC group.Methods: It was a prospective study performed on women with one previous LSCS admitted to tertiary care hospital for a period of one year from August 2018 to August 2019 at DM Waynad institute of medical sciences, Waynad.Results: In the present study 292 women with one previous LSCS were selected, among them 32 women had elective LSCS for various indications, 260 women underwent TOL. Among 260 women, 152 women achieved VBAC (58.46%) and 108 women underwent LSCS following failed TOL. Maternal morbidity was 9.61%. The incidence of scar dehiscence was 2.69% and uterine rupture was 0.38%. There was no maternal and foetal mortality in this study. NICU admission was 4.6%.Conclusions: Trial of labour should be encouraged in women with one previous LSCS with no obstetric complications

Prediction of Indoor Air Quality in a School Building Using Risk Model

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Butorphanol for Post-Operative Analgesia - A Comparative Clinical Study with Ketorolac

Introduction: Butorphanol, an opioid derivative has been shown to have, in addition to its analgesic properties, several other advantageous effects like antistressor, sedative and anti-shivering action. The efficacy and safety profile of ketorolac, yet another widely used post-operative analgesic is well documented. This study aims to compare the two analgesics. Aims and objectives: This study was conducted to compare the analgesic efficacy and other effects of butorphanol and ketorolac, administered intramuscularly, in post-operative patients who have undergone lower abdominal and pelvic surgeries. Materials and methods: 50 patients undergoing lower abdominal and pelvic surgeries under general or spinal anaesthesia were randomly divided into two Groups (25 each). At a particular level of post-operative pain, the patients Groups I and II were administered intramuscular ketorolac 30mg and butorphanol 2mg respectively. The analgesic effect was studied using Visual Analogue Scale (VAS) and the verbal category scale. Patients were monitored for the sedative action, respiratory status and other vital parameters for 300 minutes and for other adverse reactions over the next twelve hours. Observations: Butorphanol provided better analgesia within the first two hours of administration, while ketorolac was more effective at 4-5 hours. Better sedative action without any significant respiratory depressant effect was demonstrated with butorphanol. There were no clinically significant hemodynamic fluctuations or adverse reactions with butorphanol or ketorolac. Conclusions: Butorphanol provides better early analgesia as compared to ketorolac with a desirable and safe sedative effect in post-operative patients who have undergone lower abdominal and pelvic surgeries

Formative Evaluation to Determine Facilitators and Barriers to Nurse-driven Implementation: Designing an Inpatient mHealth Intervention to Support Smoking Cessation

The inpatient setting is often a missed opportunity for the introduction of technology to promote health using behavioral techniques. Nurses are stakeholders in the implementation of technology for patients in the inpatient setting and are essential for the determination of feasibility and relevance. The objective of this study was to identify facilitators and barriers for introduction of health-related patient technology, and specifically the appropriateness of mobile health (mHealth) technology in the hospital setting as identified by nurse leaders and staff. Methods of formative evaluation included nurse leader and staff semi-structured interviews and qualitative analysis. Nurses are comfortable with patients using mHealth technology in the inpatient setting. Facilitators for the introduction of technology to hospitalized patients were identified. Based on the formative evaluation findings, we developed an Implementation Program for mHealth technology introduction in the inpatient setting

Immediate and long-term results of bronchial artery embolisation for life-threatening hemoptysis in bronchiectasis

Background: Bronchial artery embolization (BAE) has been established as an effective technique in the emergency treatment of life-threatening hemoptysis, but few data concerning long-term results of the procedure are available The aim of this study was to analyze the immediate and long-term results of bronchial artery embolization (BAE) for hemoptysis due to bronchiectasis.Methods: Twenty five patients (aged 28–76 years) who underwent bronchial artery embolization with polyvinyl alcohol particles, gelatin sponge and coil for massive or continuing moderate hemoptysis caused by bronchiectasis were included in the study. These patients were followed up for 3 years. Initially patients were followed up monthly for 6months by clinical examination. Then yearly follow up by clinical and radiological examination. Results analyzed using SPSS 16 version.Results: In our study16 patients (64%) were males. 11 patients (44%) had bilateral bronchiectasis.14 patients (56%) had no rebleeding in the three year follow-up period. Only 8% developed rebleeding within 24hrs.Only one patient (4%) developed massive hemoptysis within one month and died. Other rebleed were very minimal. In our study there was no significant relation with side of bronchiectasis and rebleed.Conclusions: Bronchial artery embolisation can yield immediate and long-term benefit in patients with hemoptysis due to bronchiectasis.