Analysis of the condition of connecting electrodes to the body of the patient with the application of a defibrator

The application of defibrillators in medical practice is considered in the paper. It is shown that for automated defibrillators there is a problem of analyzing the wall of electrode connection to the patient's body during automatic defibrillator operation

The problems of utilizing graphite of stopped graphite-uranium reactors

A list of radioactive nuclides, the activity of which forms the main part of total activity of graphite stack and graphite elements of the construction of stopped industrial graphite-uranium reactors has been defined. The analysis of activity part contributed by these nuclides at different moments of time after stopping reactor was carried out. A set of construction graphite elements, in which there is a possibility of self-sustaining release of the energy stored (Wigner's energy) was determined. It was stated that the most value of the Wigner's energy is achieved in graphite constructions operated in low-temperature region or at high values of flux densities of damaging neutrons and concurrent gamma radiation

Observations on Integral and Continuous U-duality Orbits in N=8 Supergravity

One would often like to know when two a priori distinct extremal black p-brane solutions are in fact U-duality related. In the classical supergravity limit the answer for a large class of theories has been known for some time. However, in the full quantum theory the U-duality group is broken to a discrete subgroup and the question of U-duality orbits in this case is a nuanced matter. In the present work we address this issue in the context of N=8 supergravity in four, five and six dimensions. The purpose of this note is to present and clarify what is currently known about these discrete orbits while at the same time filling in some of the details not yet appearing in the literature. To this end we exploit the mathematical framework of integral Jordan algebras and Freudenthal triple systems. The charge vector of the dyonic black string in D=6 is SO(5,5;Z) related to a two-charge reduced canonical form uniquely specified by a set of two arithmetic U-duality invariants. Similarly, the black hole (string) charge vectors in D=5 are E_{6(6)}(Z) equivalent to a three-charge canonical form, again uniquely fixed by a set of three arithmetic U-duality invariants. The situation in four dimensions is less clear: while black holes preserving more than 1/8 of the supersymmetries may be fully classified by known arithmetic E_{7(7)}(Z) invariants, 1/8-BPS and non-BPS black holes yield increasingly subtle orbit structures, which remain to be properly understood. However, for the very special subclass of projective black holes a complete classification is known. All projective black holes are E_{7(7)}(Z) related to a four or five charge canonical form determined uniquely by the set of known arithmetic U-duality invariants. Moreover, E_{7(7)}(Z) acts transitively on the charge vectors of black holes with a given leading-order entropy.Comment: 43 pages, 8 tables; minor corrections, references added; version to appear in Class. Quantum Gra

Jordan Pairs, E6 and U-Duality in Five Dimensions

By exploiting the Jordan pair structure of U-duality Lie algebras in D = 3 and the relation to the super-Ehlers symmetry in D = 5, we elucidate the massless multiplet structure of the spectrum of a broad class of D = 5 supergravity theories. Both simple and semi-simple, Euclidean rank-3 Jordan algebras are considered. Theories sharing the same bosonic sector but with different supersymmetrizations are also analyzed.Comment: 1+41 pages, 1 Table; v2 : a Ref. and some comments adde

A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma

Background Pegylated arginine deiminase (ADI-PEG20; pegargiminase) depletes arginine and improves survival outcomes for patients with argininosuccinate synthetase 1 (ASS1)-deficient malignant pleural mesothelioma (MPM). Optimisation of ADI-PEG20-based therapy will require a deeper understanding of resistance mechanisms, including those mediated by the tumor microenvironment. Here, we sought to reverse translate increased tumoral macrophage infiltration in patients with ASS1-deficient MPM relapsing on pegargiminase therapy. Methods Macrophage-MPM tumor cell line (2591, MSTO, JU77) co-cultures treated with ADI-PEG20 were analyzed by flow cytometry. Microarray experiments of gene expression profiling were performed in ADI-PEG20-treated MPM tumor cells, and macrophage-relevant genetic “hits” were validated by qPCR, ELISA, and LC/MS. Cytokine and argininosuccinate analyses were performed using plasma from pegargiminase-treated patients with MPM. Results We identified that ASS1-expressing macrophages promoted viability of ADI-PEG20-treated ASS1-negative MPM cell lines. Microarray gene expression data revealed a dominant CXCR2-dependent chemotactic signature and co-expression of VEGF-A and IL-1α in ADI-PEG20-treated MPM cell lines. We confirmed that ASS1 in macrophages was IL-1α-inducible and that the argininosuccinate concentration doubled in the cell supernatant sufficient to restore MPM cell viability under co-culture conditions with ADI-PEG20. For further validation, we detected elevated plasma VEGF-A and CXCR2-dependent cytokines, and increased argininosuccinate in patients with MPM progressing on ADI-PEG20. Finally, liposomal clodronate depleted ADI-PEG20-driven macrophage infiltration and suppressed growth significantly in the MSTO xenograft murine model. Conclusions Collectively, our data indicate that ADI-PEG20-inducible cytokines orchestrate argininosuccinate fuelling of ASS1-deficient mesothelioma by macrophages. This novel stromal-mediated resistance pathway may be leveraged to optimize arginine deprivation therapy for mesothelioma and related arginine-dependent cancers

Spectra of PP-Wave Limits of M-/Superstring Theory on AdS_p x S^q Spaces

In this paper we show how one can obtain very simply the spectra of the PP-wave limits of M-theory over AdS_7(4) x S^4(7) spaces and IIB superstring theory over AdS_5 x S^5 from the oscillator construction of the Kaluza-Klein spectra of these theories over the corresponding spaces. The PP-wave symmetry superalgebras are obtained by taking the number P of ``colors'' of oscillators to be large (infinite). In this large P limit, the symmetry superalgebra osp(8*|4) of AdS_7 x S^4 and the symmetry superalgebra osp(8|4,R) of AdS_4 x S^7 lead to isomorphic PP-wave algebras, which is the semi-direct sum of su(4|2) with H^(18,16), while the symmetry superalgebra su(2,2|4) of AdS_5 x S^5 leads to the semi-direct sum of [psu(2|2) + psu(2|2) + u(1)] with H^(16,16) as its PP-wave algebra [H^(m,n) denoting a super-Heisenberg algebra with m bosonic and n fermionic generators]. The zero mode spectra of M-theory or IIB superstring theory in the PP-wave limit corresponds simply to the unitary positive energy representations of these algebras whose lowest weight vector is the Fock vacuum of all the oscillators. General positive energy supermultiplets including those corresponding to higher modes can similarly be constructed by the oscillator method.Comment: Typos corrected; references added; minor modifications to improve presentation; 37 pages, LaTeX fil