40 research outputs found
Analysis of the condition of connecting electrodes to the body of the patient with the application of a defibrator
The application of defibrillators in medical practice is considered in the paper. It is shown that for automated defibrillators there is a problem of analyzing the wall of electrode connection to the patient's body during automatic defibrillator operation
The problems of utilizing graphite of stopped graphite-uranium reactors
A list of radioactive nuclides, the activity of which forms the main part of total activity of graphite stack and graphite elements of the construction of stopped industrial graphite-uranium reactors has been defined. The analysis of activity part contributed by these nuclides at different moments of time after stopping reactor was carried out. A set of construction graphite elements, in which there is a possibility of self-sustaining release of the energy stored (Wigner's energy) was determined. It was stated that the most value of the Wigner's energy is achieved in graphite constructions operated in low-temperature region or at high values of flux densities of damaging neutrons and concurrent gamma radiation
Observations on Integral and Continuous U-duality Orbits in N=8 Supergravity
One would often like to know when two a priori distinct extremal black
p-brane solutions are in fact U-duality related. In the classical supergravity
limit the answer for a large class of theories has been known for some time.
However, in the full quantum theory the U-duality group is broken to a discrete
subgroup and the question of U-duality orbits in this case is a nuanced matter.
In the present work we address this issue in the context of N=8 supergravity in
four, five and six dimensions. The purpose of this note is to present and
clarify what is currently known about these discrete orbits while at the same
time filling in some of the details not yet appearing in the literature. To
this end we exploit the mathematical framework of integral Jordan algebras and
Freudenthal triple systems. The charge vector of the dyonic black string in D=6
is SO(5,5;Z) related to a two-charge reduced canonical form uniquely specified
by a set of two arithmetic U-duality invariants. Similarly, the black hole
(string) charge vectors in D=5 are E_{6(6)}(Z) equivalent to a three-charge
canonical form, again uniquely fixed by a set of three arithmetic U-duality
invariants. The situation in four dimensions is less clear: while black holes
preserving more than 1/8 of the supersymmetries may be fully classified by
known arithmetic E_{7(7)}(Z) invariants, 1/8-BPS and non-BPS black holes yield
increasingly subtle orbit structures, which remain to be properly understood.
However, for the very special subclass of projective black holes a complete
classification is known. All projective black holes are E_{7(7)}(Z) related to
a four or five charge canonical form determined uniquely by the set of known
arithmetic U-duality invariants. Moreover, E_{7(7)}(Z) acts transitively on the
charge vectors of black holes with a given leading-order entropy.Comment: 43 pages, 8 tables; minor corrections, references added; version to
appear in Class. Quantum Gra
Jordan Pairs, E6 and U-Duality in Five Dimensions
By exploiting the Jordan pair structure of U-duality Lie algebras in D = 3
and the relation to the super-Ehlers symmetry in D = 5, we elucidate the
massless multiplet structure of the spectrum of a broad class of D = 5
supergravity theories. Both simple and semi-simple, Euclidean rank-3 Jordan
algebras are considered. Theories sharing the same bosonic sector but with
different supersymmetrizations are also analyzed.Comment: 1+41 pages, 1 Table; v2 : a Ref. and some comments adde
A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma
Background
Pegylated arginine deiminase (ADI-PEG20; pegargiminase) depletes arginine and improves survival outcomes for patients with argininosuccinate synthetase 1 (ASS1)-deficient malignant pleural mesothelioma (MPM). Optimisation of ADI-PEG20-based therapy will require a deeper understanding of resistance mechanisms, including those mediated by the tumor microenvironment. Here, we sought to reverse translate increased tumoral macrophage infiltration in patients with ASS1-deficient MPM relapsing on pegargiminase therapy.
Methods
Macrophage-MPM tumor cell line (2591, MSTO, JU77) co-cultures treated with ADI-PEG20 were analyzed by flow cytometry. Microarray experiments of gene expression profiling were performed in ADI-PEG20-treated MPM tumor cells, and macrophage-relevant genetic “hits” were validated by qPCR, ELISA, and LC/MS. Cytokine and argininosuccinate analyses were performed using plasma from pegargiminase-treated patients with MPM.
Results
We identified that ASS1-expressing macrophages promoted viability of ADI-PEG20-treated ASS1-negative MPM cell lines. Microarray gene expression data revealed a dominant CXCR2-dependent chemotactic signature and co-expression of VEGF-A and IL-1α in ADI-PEG20-treated MPM cell lines. We confirmed that ASS1 in macrophages was IL-1α-inducible and that the argininosuccinate concentration doubled in the cell supernatant sufficient to restore MPM cell viability under co-culture conditions with ADI-PEG20. For further validation, we detected elevated plasma VEGF-A and CXCR2-dependent cytokines, and increased argininosuccinate in patients with MPM progressing on ADI-PEG20. Finally, liposomal clodronate depleted ADI-PEG20-driven macrophage infiltration and suppressed growth significantly in the MSTO xenograft murine model.
Conclusions
Collectively, our data indicate that ADI-PEG20-inducible cytokines orchestrate argininosuccinate fuelling of ASS1-deficient mesothelioma by macrophages. This novel stromal-mediated resistance pathway may be leveraged to optimize arginine deprivation therapy for mesothelioma and related arginine-dependent cancers
Spectra of PP-Wave Limits of M-/Superstring Theory on AdS_p x S^q Spaces
In this paper we show how one can obtain very simply the spectra of the
PP-wave limits of M-theory over AdS_7(4) x S^4(7) spaces and IIB superstring
theory over AdS_5 x S^5 from the oscillator construction of the Kaluza-Klein
spectra of these theories over the corresponding spaces. The PP-wave symmetry
superalgebras are obtained by taking the number P of ``colors'' of oscillators
to be large (infinite). In this large P limit, the symmetry superalgebra
osp(8*|4) of AdS_7 x S^4 and the symmetry superalgebra osp(8|4,R) of AdS_4 x
S^7 lead to isomorphic PP-wave algebras, which is the semi-direct sum of
su(4|2) with H^(18,16), while the symmetry superalgebra su(2,2|4) of AdS_5 x
S^5 leads to the semi-direct sum of [psu(2|2) + psu(2|2) + u(1)] with H^(16,16)
as its PP-wave algebra [H^(m,n) denoting a super-Heisenberg algebra with m
bosonic and n fermionic generators]. The zero mode spectra of M-theory or IIB
superstring theory in the PP-wave limit corresponds simply to the unitary
positive energy representations of these algebras whose lowest weight vector is
the Fock vacuum of all the oscillators. General positive energy supermultiplets
including those corresponding to higher modes can similarly be constructed by
the oscillator method.Comment: Typos corrected; references added; minor modifications to improve
presentation; 37 pages, LaTeX fil