43 research outputs found
New developments in the pathology of malignant lymphoma: a review of the literature published from January to August 2009
Get PDFData for: Sex Differences in Academic Rank, Scholarly Productivity, and NIH Funding of United States Academic-Affiliated Cornea Specialists
No full textAcademic Rank, Scholarly Productivity, and NIH Funding of United States Academic-Affiliated Cornea SpecialistsTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
Ciclo di Accrescimento e Differenziazione delle Gemme in Piante Perenni Nel Territorio di Bari
No full textDer CRW1-Index: Identifizierung von Augen mit vorheriger Myopie-Laserkorrektur nur mit einem Swept-Source OCT-Biometer
No full textNonivasive continuous positive airway pressure delivered by helmet in hematological malignancy patients with hypoxemic acute respiratory failure
No full textInfluenza dei prodotti di escrezione di alcuni funghi isolati dall'apparato Radicale della barbabietola sulla Germinazione del mais
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CD4 \u3csup\u3e+\u3c/sup\u3efoxp3 \u3csup\u3e+\u3c/sup\u3e T-regulatory cells in noninfectious uveitis
No full textObjective: To evaluate CD4 +Foxp3 + (forkhead box P3) T-regulatory cell populations in patients with uveitis and to determine if T-regulatory cell populations are associated with disease features. Methods: Patients with uveitis were evaluated for CD4 +Foxp3 +T-regulatory cells by flow cytometry. Systemic and ocular diagnoses, disease activity, and the resence of cystoid macular edema were reviewed. Percentages of CD4 +Foxp3 +lymphocytes were compared for patients with inactive vs active disease, systemic vs ocular diagnoses, and the presence or absence of cys-toid macular edema. Real-time polymerase chain reaction testing was performed on 2 patients with extremely low CD4 +oxp3 +cell populations to assess Foxp3 mRNA. Results: A total of 20 patients with intermediate uveitis, posterior uveitis, and panuveitis were evaluated. The mean age was 40.6 years and the mean visual acuity was 20/57. Percentages of CD4 +Foxp3 + cells were lower in patients with active compared with inactive uveitis (P\u3c 5). No differences in T-regulatory cells were observed between the other subgroups. Two patients with recalcitrant uveitis who demonstrated less than 1% CD4 +Foxp3 + lymphocytes showed extremely low or absent Foxp3 mRNA. Conclusion: T-regulatory cells are reduced in patients with active compared with inactive disease. Severe depletion of CD4 +Foxp3 + T cells and Foxp3 mRNA in 2 patients with severe uveitis suggests that loss of the T-regulatory cells of uveitis may be a salient feature in certain patients. ©2009 American Medical Association. All rights reserved
