Principles of Discrete Time Mechanics: IV. The Dirac Equation, Particles and Oscillons

We apply the principles of discrete time mechanics discussed in earlier papers to the first and second quantised Dirac equation. We use the Schwinger action principle to find the anticommutation relations of the Dirac field and of the particle creation operators in the theory. We find new solutions to the discrete time Dirac equation, referred to as oscillons on account of their extraordinary behaviour. Their principal characteristic is that they oscillate with a period twice that of the fundamental time interval T of our theory. Although these solutions can be associated with definite charge, linear momentum and spin, such objects should not be observable as particles in the continuous time limit. We find that for non-zero T they correspond to states with negative squared norm in Hilbert space. However they are an integral part of the discrete time Dirac field and should play a role in particle interactions analogous to the role of longitudinal photons in conventional quantum electrodynamics.Comment: 27 pages LateX; published versio

Mass spectrometry protein expression profiles in colorectal cancer tissue associated with clinico-pathological features of disease.

Background: Studies of several tumour types have shown that expression profiling of cellular protein extracted from surgical tissue specimens by direct mass spectrometry analysis can accurately discriminate tumour from normal tissue and in some cases can sub-classify disease. We have evaluated the potential value of this approach to classify various clinico-pathological features in colorectal cancer by employing matrix-assisted laser desorption ionisation time of-flight-mass spectrometry (MALDI-TOF MS). Methods: Protein extracts from 31 tumour and 33 normal mucosa specimens were purified, subjected to MALDI-Tof MS and then analysed using the `GenePattern' suite of computational tools (Broad Institute, MIT, USA). Comparative Gene Marker Selection with either a t-test or a signal-to-noise ratio (SNR) test statistic was used to identify and rank differentially expressed marker peaks. The k-nearest neighbours algorithm was used to build classification models either using separate training and test datasets or else by using an iterative, `leave-one-out' cross-validation method. Results: 73 protein peaks in the mass range 1800-16000Da were differentially expressed in tumour verses adjacent normal mucosa tissue (P <= 0.01, false discovery rate <= 0.05). Unsupervised hierarchical cluster analysis classified most tumour and normal mucosa into distinct cluster groups. Supervised prediction correctly classified the tumour/normal mucosa status of specimens in an independent test spectra dataset with 100\% sensitivity and specificity (95\% confidence interval: 67.9-99.2\%). Supervised prediction using `leave-one-out' cross validation algorithms for tumour spectra correctly classified 10/13 poorly differentiated and 16/18 well/moderately differentiated tumours (P = < 0.001; receiver-operator characteristics - ROC - error, 0.171); disease recurrence was correctly predicted in 5/6 cases and disease-free survival (median follow-up time, 25 months) was correctly predicted in 22/23 cases (P = < 0.001; ROC error, 0.105). A similar analysis of normal mucosa spectra correctly predicted 11/14 patients with, and 15/19 patients without lymph node involvement (P = 0.001; ROC error, 0.212). Conclusions: Protein expression profiling of surgically resected CRC tissue extracts by MALDI-TOF MS has potential value in studies aimed at improved molecular classification of this disease. Further studies, with longer follow-up times and larger patient cohorts, that would permit independent validation of supervised classification models, would be required to confirm the predictive value of tumour spectra for disease recurrence/patient survival

Herbal medicines in Hawaii from tradition to convention.

The stories of kava and chaulmoogra demonstrate the importance of herbal products in ancient and recent Hawaiian medicine. Kava is a psychoactive beverage that has been used ceremonially for millennia throughout the Pacific. It is a nonfermented depressant that causes tranquil intoxication in which thoughts and memory remain clear. Its broad pharmacologic activity led to use in Hawaii to treat skin disorders and later in Germany to treat gonorrhea. Kava is now available outside the Pacific basin as a relaxant, emerging as a popular, albeit deritualized, natural product. In the late 19th century, the main treatment for leprosy was chaulmoogra, extracted from Hydnocarpus seeds. Chaulmoogra had been a traditional treatment for skin diseases in Ayurvedic and Chinese medicine. Chaulmoogra from Asian markets was expensive and usually adulterated so the USDA decided to plant Hydnocarpus in Hawaii. Joseph Rock, a botanist at University of Hawaii, trekked through southeast Asia collecting fresh seeds to plant on Oahu. Rock's trees provided chaulmoogra for leprosy patients on Molokai and elsewhere until it was replaced by dapsone. Chaulmoogra, once the treatment for leprosy worldwide, is now nearly forgotten; kava, once poorly known outside the Pacific, is now a widely-used alternative medicine. Hawaii will probably continue its role in the transition of plants from traditional use to conventional use

Space and biotechnology: An industry profile

The results of a study conducted by the Center for Space and Advanced Technology (CSAT) for NASA-JSC are presented. The objectives were to determine the interests and attitudes of the U.S. biotechnology industry toward space biotechnology and to prepare a concise review of the current activities of the biotechnology industry. In order to accomplish these objectives, two primary actions were taken. First, a questionnaire was designed, reviewed, and distributed to U.S. biotechnology companies. Second, reviews of the various biotechnology fields were prepared in several aspects of the industry. For each review, leading figures in the field were asked to prepare a brief review pointing out key trends and current industry technical problems. The result is a readable narrative of the biotechnology industry which will provide space scientists and engineers valuable clues as to where the space environment can be explored to advance the U.S. biotechnology industry

Short period eclipsing binary candidates identified using SuperWASP

We present light curves and periods of 53 candidates for short period eclipsing binary stars identified by SuperWASP. These include 48 newly identified objects with periods <2 × 10^4 s (~0.23 d), as well as the shortest period binary known with main sequence components (GSC2314–0530 = 1SWASP J022050.85 + 332047.6) and four other previously known W UMa stars (although the previously reported periods for two of these four are shown to be incorrect). The period distribution of main sequence contact binaries shows a sharp cut-off at a lower limit of around 0.22 d, but until now, very few systems were known close to this limit. These new candidates will therefore be important for understanding the evolution of low mass stars and to allow investigation of the cause of the period cut-off

Recovering Solar Toroidal Field Dynamics From Sunspot Location Patterns

We analyze both Kitt Peak magnetogram data and MDI continuum intensity sunspot data to search for the following solar toroidal band properties: width in latitude and the existence of a tipping instability (longitudinal m=1 mode) for any time during the solar cycle. To determine the extent which we can recover the toroidal field dynamics, we forward model artificially generated sunspot distributions from subsurface toroidal fields we assigned certain properties. We analyzed two sunspot distribution parameters using MDI and model data: the average latitudinal separation of sunspot pairs as a function of longitudinal separation, and the number of sunspot pairs creating a given angle with respect to the E-W direction. A toroidal band of 10 degrees width with a constant tipping of 5 degrees best fits MDI data early in the solar cycle. A toroidal band of 20 degrees width with a tipping amplitude decreasing in time from 5 to 0 degrees best fits MDI data late in the solar cycle. Model data generated by untipped toroidal bands cannot fit MDI high latitude data and can fit only one parameter at low latitudes. Tipped toroidal bands satisfy chi squared criteria at both high and low latitudes. We conclude this is evidence to reject the null hypothesis - that toroidal bands in the solar tachocline do not experience a tipping instability - in favor of the hypothesis that the toroidal band experiences an m=1 tipping instability. Our finding that the band widens from ~10 degrees early in the solar cycle to ~20 degrees late in the solar cycle may be explained in theory by magnetic drag spreading the toroidal band due to altered flow along the tipped field lines.Comment: This paper is accepted to Astrophysical Journal, September 2005 issu

Newtonian Counterparts of Spin 2 Massless Discontinuities

Massive spin 2 theories in flat or cosmological ($\Lambda \ne 0$) backgrounds are subject to discontinuities as the masses tend to zero. We show and explain physically why their Newtonian limits do not inherit this behaviour. On the other hand, conventional ``Newtonian cosmology'', where $\Lambda$ is a constant source of the potential, displays discontinuities: e.g. for any finite range, $\Lambda$ can be totally removed.Comment: 6 pages, amplifies the ``Newtonian cosmology'' analysis. To appear as a Class. Quantum Grav. Lette

Impact Assessment of agricultural research and development to reduce virus problems in tomato production in Mali: Farmers perceptions

Pests and diseases caused by bacteria, nematodes, fungi and viruses cause significant losses to tomato in West Africa. This study, carried-out within the framework of the IPM-CRSP implemented jointly by IITA, IER and Virginia Tech. and State University, assesses farmers’ perceptions on tomato pests and analyzes factors affecting pest management decision-making. Surveys were carried out in three tomato production areas where pests and diseases are major agricultural problems encountered by farmers. Data were collected a sample of from 343 farmers through a set of questionnaires on tomato production systems. Farmer’s decision-making in pest management was modeled using an econometrics Logit probability model. Results show that the main disease reported by most farmers is tomato leaf curl viruses transmitted by whitefly (Bemissia tabaci). The spray of chemicals was not effective on whitefly-transmitted viruses, but the observance of host free period could significantly reduce the population of whiteflies. Key factors affecting farmers’ pest management decision-making are gender; share of tomato income from household income and the level of farm income. Men are more involved in tomato production due to access to pesticide and effective demand for pesticides because of incomes (purchasing power). This paper concludes that tomato production can increase significantly if improved varieties tolerant to whitefly viruses are developed and disseminated, and farmers trained on the appropriate use of chemicals using a participatory approach to raise their level of awareness and information on effective pesticide use and pest-management decision-making.Agricultural and Food Policy, Agricultural Finance, Crop Production/Industries, Demand and Price Analysis, Environmental Economics and Policy, Farm Management, Food Consumption/Nutrition/Food Safety, Food Security and Poverty, International Relations/Trade, Marketing, Productivity Analysis, Research and Development/Tech Change/Emerging Technologies,

High mass X-ray binaries in the NIRorbital solutions of two highly obscured systems

The maximum mass of a neutron star (NS) is poorly defined. Theoretical attempts to define this mass have thus far been unsuccessful. Observational results currently provide the only means of narrowing this mass range down. Eclipsing X-ray binary (XRB) pulsar systems are the only interacting binaries in which the mass of the NS may be measured directly. Only 10 such systems are known to exist, 6 of which have yielded NS masses in the range 1.06 - 1.86 M$_{\odot}$.We present the first orbital solutions of two further eclipsing systems, OAO 1657-415 and EXO 1722-363, whose donor stars have only recently been identified. Using observations obtained using the VLT/ISAAC NIR spectrograph, our initial work was concerned with providing an accurate spectral classification of the two counterpart stars, leading to a consistent explanation of the mechanism for spin period evolution of OAO 1657-415. Calculating radial velocities allowed orbital solutions for both systems to be computed. These are the first accurate determinations of the NS and counterpart masses in XRB pulsar systems to be made employing NIR spectroscopy.Comment: 5 pages, 3 figures, contribution to the proceedings of "The multi-wavelength view of hot, massive stars", 39th Li`ege Int. Astroph. Coll., 12-16 July 201

Representation in Westminster in the 1990s : The ghost of Edmund Burke

Why are 'trustee' notions of representation still invoked in the UK House of Commons in the 1990s? In answering this question this article analyses the premises of Burkean theory and the arguments that these premises are of little relevance in the late twentieth century. Despite these dismissals of trusteeship, Burkean ideas are still articulated in the Commons some 200 years after they were first voiced. The idea of trusteeship can prove extremely useful to justify the actions of representatives when those actions conflict with constituency 'opinion', party policy or the wishes of interest groups. Examples of the occasions when Burkean notions have been invoked in the 1990s are provided