Metals loads into the Mediterranean Sea: estimate of Sarno River inputs and ecological risk

The metals pollution in the Sarno River and its environmental impact on the Gulf of Naples (Tyrrhenian Sea, Central Mediterranean Sea) were estimated. Eight selected metals (As, Hg, Cd, Cr, Cu, Ni, Pb and Zn) were determined in the water dissolved phase (DP), suspended particulate matter (SPM) and sediment samples. Selected metals concentrations ranged from 0.32 to 1,680.39 μg l(-1) in water DP, from 103.6 to 7,734.6 μg l(-1) in SPM and from 90.7 to 2,470.3 mg kg(-1) in sediment samples. Contaminant discharges of selected metals into the sea were calculated in about 13,977.6 kg year(-1) showing that this river should account as one of the main contribution sources of metals to the Tyrrhenian Sea

Exclusive semileptonic BB-meson decays using lattice QCD and unitarity

We present the results of the application of the Dispersion Matrix approach to exclusive semileptonic $B$-meson decays. This method allows to determine the hadronic form factors in a non-perturbative and completely model-independent way. Starting from lattice results available at large values of the momentum transfer, the behaviour of the form factors in their whole kinematical range is obtained without introducing any parameterization of their momentum dependence. We will focus on the determination of the Cabibbo-Kobayashi-Maskawa matrix elements $\vert V_{cb} \vert$ and $\vert V_{ub} \vert$ through the analysis of $B_{(s)} \to D_{(s)}^{(*)} \ell \nu$ and $B_{(s)} \to \pi(K) \ell \nu$ decays. New theoretical determinations of the Lepton Flavour Universality ratios relevant for these transitions will be also presented.Comment: 8 pages, 5 figures, 2 tables; contribution to QCD@Work - International Workshop on QCD - Theory and Experiment, 27 - 30 June 2022, Lecce (Italy). arXiv admin note: substantial text overlap with arXiv:2205.1395

The DM approach to semileptonic heavy-to-heavy and heavy-to-light BB decays

We present the results of the application of the Dispersion Matrix approach to semileptonic heavy-to-heavy and heavy-to-light $B$-meson decays. This method allows to determine the hadronic form factors in a non-perturbative and model-independent way. Starting from the available lattice results at large values of the momentum transfer, we obtain the behaviour of the form factors in their whole kinematical range without introducing any parameterization of their momentum dependence. We will focus on the determination of the Cabibbo-Kobayashi-Maskawa matrix elements $\vert V_{cb} \vert$ and $\vert V_{ub} \vert$ through the analysis of $B \to D^{(*)} \ell \nu$, $B_s \to D_s^{(*)} \ell \nu$, $B \to \pi \ell \nu$ and $B_s \to K \ell \nu$ decays. New theoretical determinations of the Lepton Flavour Universality ratios relevant for these transitions will be also presented, by focusing in particular on the $R(D_{(s)}^{(*)})$ ratios.Comment: 9 pages, 3 figures. Proceedings for the 39th International Symposium on Lattice Field Theory (Lattice 2022). arXiv admin note: substantial text overlap with arXiv:2209.15413, arXiv:2205.13952; text overlap with arXiv:2211.0723

Rituximab Unveils Hypogammaglobulinemia and Immunodeficiency in Children with Autoimmune Cytopenia

BACKGROUND: Rituximab (RTX; anti-CD20 mAb) is a treatment option in children with refractory immune thrombocytopenia, autoimmune hemolytic anemia (AHA), and Evans syndrome (ES). Prevalence and clinical course of RTX-induced hypogammaglobulinemia in these patients are poorly known. OBJECTIVE: To evaluate the prevalence and risk factors for persistent hypogammaglobulinemia (PH) after RTX use. METHODS: Clinical and immunologic data from children treated with RTX for immune thrombocytopenia, AHA, and ES were collected from 16 Italian centers and 1 UK center at pre-RTX time point (0), +6 months, and yearly, up to 4 years post-RTX. Patients with previously diagnosed malignancy or primary immune deficiency (PID) were excluded. RESULTS: We analyzed 53 children treated with RTX for immune thrombocytopenia (n = 36), AHA (n = 13), and ES (n = 4). Median follow-up was 30 months (range, 12-48). Thirty-two percent of patients (17 of 53) experienced PH, defined as IgG levels less than 2 SD for age at last follow-up (>12 months after RTX). Significantly delayed B-cell recovery was observed in children experiencing PH (hazard ratio, 0.55; P < .05), and 6 of 17 (35%) patients had unresolved B-cell lymphopenia at last follow-up. PH was associated with IgA and IgM deficiency, younger age at RTX use (51 vs 116 months; P < .01), a diagnosis of AHA/ES, and better response to RTX. Nine patients with PH (9 of 17 [53%]) were eventually diagnosed with a PID. CONCLUSIONS: Post-RTX PH is a frequent condition in children with autoimmune cytopenia; a sizable proportion of patients with post-RTX PH were eventually diagnosed with a PID. In-depth investigation for PID is therefore recommended in these patients

Analisi di configurazioni critiche di noccioli PWR di piccola taglia ad alto burnup

Questo rapporto è stato emesso nell'ambito del secondo PAR dell'accordo di programma ENEA-MSE e costituisce uno dei deliverable dell'obiettivo M 'Progettazione core innovativo' della linea progettuale LP2 'Reattori Evolutivi INTD - Intemational Near Term Deployment' del tema di ricerca 'Nuovo Nucleare da Fissione'. Il documento riporta i risultati di uno studio preliminare sulla fattibilità di alcuni modelli di nocciolo per un reattore ad acqua leggera in pressione senza controllo chimico della reattività e di taglia non superiore ai 150 MW. Per i calcoli di cella e di evoluzione sono stati utilizzati i codici NEWT e TRITON del sistema SCALE 6 e le sezioni d'urto ottenute dalla libreria ENDF/B-V

Diastereo- and enantioselective direct aldol reactions in aqueous medium: A new highly efficient proline-sugar chimeric catalyst

A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol reactions, is presented. Excellent results, in terms of chemical yields and diastereo-/enantiomeric ratios, are reported for the catalyzed additions of cyclohexanone to variously substituted benzaldehydes. Copyright © 2011 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim

Vanillin prevents doxorubicin-induced apoptosis and oxidative stress in rat H9c2 cardiomyocytes

Doxorubicin (doxo) is an effective anticancer compound in several tumor types. However, as a consequence of oxidative stress induction and ROS overproduction, its high cardiotoxicity demands urgent attention. Vanillin possesses antioxidant, antiproliferative, antidepressant and anti-glycating properties. Therefore, we investigated the potential vanillin protective effects against doxo-induced cardiotoxicity in H9c2 cells. Using multiparametric approach, we demonstrated that vanillin restored both cell viability and damage in response to doxo exposure. Contextually, vanillin decreased sub-G1 appearance and caspase-3 and PARP1 activation, reducing the doxo-related apoptosis induction. From a mechanistic point of view, vanillin hindered doxo-induced ROS accumulation and impaired the ERK phosphorylation. Notably, besides the cardioprotective effects, vanillin did not counteract the doxo effectiveness in osteosarcoma cells. Taken together, our results suggest that vanillin ameliorates doxo-induced toxicity in H9c2 cells, opening new avenues for developing alternative therapeutic approaches to prevent the anthracycline-related cardiotoxicity and to improve the long-term outcome of antineoplastic treatment

Proline-β3-amino-ester dipeptides as efficient catalysts for enantioselective direct aldol reaction in aqueous medium

(Chemical Equation Presented) Dipeptides obtained from L-proline and β3-L-amino acids are reported to catalyze enantioselective direct aldol reaction in aqueous medium, leading to significant anti: syn diastereomeric ratios and enantiomeric excesses. The simple introduction of a polar substituent at the C-2 position of the β3-L-amino acid was also found to enhance appreciably both diastereo- and enantioselectivity of the catalyst. © 2009 American Chemical Society