Anatomical Changes in the Skin of Rattus Norvegicus After Artificial UV Exposure

Acute and subacute artificial UV exposure to albino rats exhibit morphological and histo-anatomical changes in the skin of albino rat. The anatomical changes include hyperplasia, hyperkeratosis, hypergranulosis and acanthosis beside numerical changes in keratinocytes, Langerhans, melanocytes and fibroblast seen after acute and subacute artificial UVB exposure

A Heavy Higgs and a Light Sneutrino NLSP in the MSSM with Enhanced SU(2) D-terms

The Minimal Supersymmetric extension of the Standard Model provides a solution to the hierarchy problem and leads to the presence of a light Higgs. A Higgs boson with mass above the present experimental bound may only be obtained for relatively heavy third generation squarks, requiring a precise, somewhat unnatural balance between different contributions to the effective Higgs mass parameter. It was recently noticed that somewhat heavier Higgs bosons, which are naturally beyond the LEP bound, may be obtained by enhanced weak SU(2) D-terms. Such contributions appear in models with an enhanced electroweak gauge symmetry, provided the supersymmetry breaking masses associated with the scalars responsible for the breakdown of the enhanced gauge symmetry group to the Standard Model one, are larger than the enhanced symmetry breaking scale. In this article we emphasize that the enhanced SU(2) D-terms will not only raise the Higgs boson mass but also affect the spectrum of the non-standard Higgs bosons, sleptons and squarks, which therefore provide a natural contribution to the T parameter, compensating for the negative one coming from the heavy Higgs boson. The sleptons and non-standard Higgs bosons of these models, in particular, may act in a way similar to the so-called inert Higgs doublet. The phenomenological properties of these models are emphasized and possible cosmological implications as well as collider signatures are described.Comment: 30 pages, 8 figure

Dimer Decimation and Intricately Nested Localized-Ballistic Phases of Kicked Harper

Dimer decimation scheme is introduced in order to study the kicked quantum systems exhibiting localization transition. The tight-binding representation of the model is mapped to a vectorized dimer where an asymptotic dissociation of the dimer is shown to correspond to the vanishing of the transmission coefficient thru the system. The method unveils an intricate nesting of extended and localized phases in two-dimensional parameter space. In addition to computing transport characteristics with extremely high precision, the renormalization tools also provide a new method to compute quasienergy spectrum.Comment: There are five postscript figures. Only half of the figure (3) is shown to reduce file size. However, missing part is the mirror image of the part show

Collision and symmetry-breaking in the transition to strange nonchaotic attractors

Strange nonchaotic attractors (SNAs) can be created due to the collision of an invariant curve with itself. This novel ``homoclinic'' transition to SNAs occurs in quasiperiodically driven maps which derive from the discrete Schr\"odinger equation for a particle in a quasiperiodic potential. In the classical dynamics, there is a transition from torus attractors to SNAs, which, in the quantum system is manifest as the localization transition. This equivalence provides new insights into a variety of properties of SNAs, including its fractal measure. Further, there is a {\it symmetry breaking} associated with the creation of SNAs which rigorously shows that the Lyapunov exponent is nonpositive. By considering other related driven iterative mappings, we show that these characteristics associated with the the appearance of SNA are robust and occur in a large class of systems.Comment: To be appear in Physical Review Letter

The family planning know-do gap among married women of reproductive age in urban Pakistan

Objective: To examine the prevalence and predictors of family planning (FP) know-do gaps among married women of reproductive age (MWRA) in low socio-economic urban areas of Karachi, Pakistan.Design: This was a cross-sectional survey of randomly selected 7288 MWRA (16-49 years) to identify predictors of the know-do gap in FP using a logistic regression model.Results: More than one third (35.5%) of MWRA had FP know-do gap, i.e., despite having a knowledge of contraceptives and desire to limit or delay childbearing, they were not using contraceptives. Women were less likely to use FP if they were getting older (25-35 years: OR 1.45, 95% CI 1.09-1.94; \u3e35 years: OR 3.02, 95% CI 1.90-4.80), from certain ethnicities (Sindhi: OR 1.64, 95% CI 1.11-2.42; Saraiki: OR 1.66, 95% CI 1.01-2.71; other minorities: OR 2.37, 95% CI 1.63-3.44); did not receive FP counselling: OR 1.43, 95% CI 1.13-1.80; and had not made a joint decision on FP: OR 1.44, 95% CI 1.06-1.98). Conversely, women were more likely to use contraceptives if they had \u3e10 years of schooling (OR 0.66, 95% CI 0.46-0.94), with each increasing number of a living child (OR 0.68, 95% CI 0.62-0.75) and each increasing number of contraceptive method known (OR 0.93, 95% CI 0.88-0.98).Conclusion: The predictors associated with the FP know-do gap among MWRA should be considered when planning future strategies to improve the contraceptive prevalence rate in Pakistan

A 125 GeV SM-like Higgs in the MSSM and the γγ\gamma \gamma rate

We consider the possibility of a Standard Model (SM)-like Higgs in the context of the Minimal Supersymmetric Standard Model (MSSM), with a mass of about 125 GeV and with a production times decay rate into two photons which is similar or somewhat larger than the SM one. The relatively large value of the SM-like Higgs mass demands stops in the several hundred GeV mass range with somewhat large mixing, or a large hierarchy between the two stop masses in the case that one of the two stops is light. We find that, in general, if the heaviest stop mass is smaller than a few TeV, the rate of gluon fusion production of Higgs bosons decaying into two photons tends to be somewhat suppressed with respect to the SM one in this region of parameters. However, we show that an enhancement of the photon decay rate may be obtained for light third generation sleptons with large mixing, which can be naturally obtained for large values of $\tan\beta$ and sizable values of the Higgsino mass parameter.Comment: 14 pages, 4 figures. Corrected small typos and added reference

Free radical scavenging activity of Lantana aculeata root extract in hyperlipidemic rats.

Abstract: Lantana aculeata is a common weed that grows abundantly in many parts of India. The aerial part of the plant is reported to be toxic while the roots were found to be non-toxic when tested in albino rats. The alcoholic extract of the roots showed a significant hypolipidemic activity in normal rats. Hence the roots were studied for their free radical scavenging potential in hyperlipidemic animals by administering the alcoholic extract (LAR) in doses of 25, 50 and 100 mg/kg for 30 days. The levels of LPO, non-enzymatic antioxidant (TRG) and enzymatic antioxidants viz. SOD, CAT and GPx that showed changes in diseased condition were reverted back to near normal values by LAR extract treatment of plasma, liver and heart tissues. The presence of flavonoids besides oleanolic acid in large amounts might have caused the observed effect

Impact of natural killer cells on outcomes after allogeneic hematopoietic stem cell transplantation: A systematic review and meta-analysis.

Background: Natural killer (NK) cells play a vital role in early immune reconstitution following allogeneic hematopoietic stem cell transplantation (HSCT). Methods: A literature search was performed on PubMed, Cochrane, and Clinical trials.gov through April 20, 2022. We included 21 studies reporting data on the impact of NK cells on outcomes after HSCT. Data was extracted following the PRISMA guidelines. Pooled analysis was done using the meta-package (Schwarzer et al.). Proportions with 95% confidence intervals (CI) were computed. Results: We included 1785 patients from 21 studies investigating the impact of NK cell reconstitution post-HSCT (8 studies/1455 patients), stem cell graft NK cell content (4 studies/185 patients), therapeutic NK cell infusions post-HSCT (5 studies/74 patients), and pre-emptive/prophylactic NK cell infusions post-HSCT (4 studies/77 patients). Higher NK cell reconstitution was associated with a better 2-year overall survival (OS) (high: 77%, 95%CI 0.73-0.82 vs low: 55%, 95%CI 0.37-0.72; n=899), however, pooled analysis for relapse rate (RR) or graft versus host disease (GVHD) could not be performed due to insufficient data. Higher graft NK cell content demonstrated a trend towards a better pooled OS (high: 65.2%, 95%CI 0.47-0.81 vs low: 46.5%, 95%CI 0.24-0.70; n=157), lower RR (high: 16.9%, 95%CI 0.10-0.25 vs low: 33%, 95%CI 0.04-0.72; n=157), and lower acute GVHD incidence (high: 27.6%, 95%CI 0.20-0.36 vs low: 49.7%, 95%CI 0.26-0.74; n=157). Therapeutic NK or cytokine-induced killer (CIK) cell infusions for hematologic relapse post-HSCT reported an overall response rate (ORR) and complete response (CR) of 48.9% and 11% with CIK cell infusions and 82.8% and 44.8% with NK cell infusions, respectively. RR, acute GVHD, and chronic GVHD were observed in 55.6% and 51.7%, 34.5% and 20%, and 20.7% and 11.1% of patients with CIK and NK cell infusions, respectively. Pre-emptive donor-derived NK cell infusions to prevent relapse post-HSCT had promising outcomes with 1-year OS of 69%, CR rate of 42%, ORR of 77%, RR of 28%, and acute and chronic GVHD rates of 24.9% and 3.7%, respectively. Conclusion: NK cells have a favorable impact on outcomes after HSCT. The optimal use of NK cell infusions post-HSCT may be in a pre-emptive fashion to prevent disease relapse