The influence of end of day silicone hydrogel daily disposable contact lens fit on ocular comfort, physiology and lens wettability

Purpose: To quantify the end-of-day silicone-hydrogel daily disposable contact lens fit and its influence of on ocular comfort, physiology and lens wettability. Methods: Thirty-nine subjects (22.1. ±. 3.5 years) were randomised to wear each of 3 silicone-hydrogel daily-disposable contact lenses (narafilcon A, delefilcon A and filcon II 3), bilaterally, for one week. Lens fit was assessed objectively using a digital video slit-lamp at 8, 12 and 16. h after lens insertion. Hyperaemia, non-invasive tear break-up time, tear meniscus height and comfort were also evaluated at these timepoints, while corneal and conjunctival staining were assessed on lens removal. Results: Lens fit assessments were not different between brands (P > 0.05), with the exception of the movement at blink where narafilcon A was more mobile. Overall, lag reduced but push-up speed increased from 8 to 12. h (P 0.05). Movement-on-blink was unaffected by wear-time (F = 0.403, P = 0.670). A more mobile lens fit with one brand did not indicate that person would have a more mobile fit with another brand (r = -0.06 to 0.63). Lens fit was not correlated with comfort, ocular physiology or lens wettability (P > 0.01). Conclusions: Among the lenses tested, objective lens fit changed between 8. h and 12. h of lens wear. The weak correlation in individual lens fit between brands indicates that fit is dependent on more than ocular shape. Consequently, substitution of a different lens brand with similar parameters will not necessarily provide comparable lens fit

Retinal Microvascular Dysfunction Occurs Early and Similarly in Mild Alzheimer’s Disease and Primary-Open Angle Glaucoma Patients

Purpose: To assess the similarities and differences in retinal microvascular function between mild Alzheimer’s disease (AD) patients, early-stage primary open angle glaucoma (POAG) patients and healthy controls. Methods: Retinal vessel reactivity to flickering light was assessed in 10 AD, 19 POAG and 20 healthy age matched control patients by means of dynamic retinal vessel analysis (DVA, IMEDOS, GmbH, Jena, Germany) according to an established protocol. All patients additionally underwent BP measurements and blood analysis for glucose and lipid metabolism markers. Results: AD and POAG patients demonstrated comparable alterations in retinal artery reactivity, in the form of an increased arterial reaction time (RT) to flicker light on the final flicker cycle (p = 0.009), which was not replicated by healthy controls (p > 0.05). Furthermore, the sequential changes in RT on progressing from flicker one to flicker three were found to differ between healthy controls and the two disease groups (p = 0.001). Conclusion: AD and POAG patients demonstrate comparable signs of vascular dysfunction in their retinal arteries at the early stages of their disease process. This provides support for the concept of a common underlying vascular aetiology in these two neurodegenerative diseases

Mutational analysis in podocin-associated hereditary nephrotic syndrome in Polish patients: founder effect in the Kashubian population

Hereditary nephrotic syndrome is caused by mutations in a number of different genes, the most common being NPHS2. The aim of the study was to identify the spectrum of NPHS2 mutations in Polish patients with the disease. A total of 141 children with steroid-resistant nephrotic syndrome (SRNS) were enrolled in the study. Mutational analysis included the entire coding sequence and intron boundaries of the NPHS2 gene. Restriction fragment length polymorphism (RFLP) and TaqMan genotyping assay were applied to detect selected NPHS2 sequence variants in 575 population-matched controls. Twenty patients (14 %) had homozygous or compound heterozygous NPHS2 mutations, the most frequent being c.1032delT found in 11 children and p.R138Q found in four patients. Carriers of the c.1032delT allele were exclusively found in the Pomeranian (Kashubian) region, suggesting a founder effect origin. The 14 % NPHS2 gene mutation detection rate is similar to that observed in other populations. The heterogeneity of mutations detected in the studied group confirms the requirement of genetic testing the entire NPHS2 coding sequence in Polish patients, with the exception of Kashubs, who should be initially screened for the c.1032delT deletion

Illumination of St. Joseph Church in Poznan.

W artykule, na przykładzie kościoła p.w. św. Józefa w Poznaniu, opisano wybrane problemy związane z iluminacją zabytkowych obiektów architektonicznych, zlokalizowanych na zurbanizowanym terenie . Istotny wpływ na wybór ostatecznego rozwiązania oświetlenia fasady obiektu ma nie tylko wizja projektanta, często ograniczona przez konserwatorskie wymagania, ale również lokalizacja na uzbrojonym terenie. Wskazano na istotną rolę wizualizacji komputerowych, wspomagających wybór ostatecznej metody iluminacji, wiążący się nie tylko z doborem odpowiedniego sprzętu oświetleniowego, ale również z określeniem dopuszczalnej lokalizacji opraw oświetleniowych, uzależnionej ściśle od warunków technicznych.Chosen aspects of illumination concepts of historical buildings are described in the article. The computer visualizations of lighting variants and final solution of St. Joseph Church illumination in Poznan are presented

Parameters of popular, commercially available, red lamps for darkroom use

Celem badań było sprawdzenie czy ogólnodostępne lampy czerwone mogłyby pełnić funkcję lamp ciemniowych w amatorskiej ciemni. W artykule zaprezentowano pomiary fotometryczne i elektryczne kilku lamp czerwonych. Wyniki zaprezentowano na wykresach. Do badań wykorzystano cztery rodzaje papierów fotograficznych, które poddano naświetlaniu i wywołaniu. Wywołane papiery porównano ze sobą organoleptycznie oraz poddano pomiarom densytometrycznym co potwierdziło spodziewane efekty.Nowadays the most popular is digital photography. However there are still some people keen on traditional photo printing. According to that situation the problem of availability darkroom lamps occurs. The article contains information and comparison of spectrum and electrical parameters popular commercially available red lamps. In addition results of paper fogging of most popular brands will be presented

Illumination of historical architectonic facilities and buildings using as an example the St. Joseph Church in Poznań

In the article, using as an example the St. Joseph Church in Poznań, there has been described selected problems connected with the illumination of historical architectonic facilities and building. The choice of the selected illumination method is made using the designer imagination and conservator’s enquiry requirements. Technical conditions, related with the building location on the area equipped with utilities, may have significant influence on choosing the final solution for the lighting. In such situation computer visualizations become the tool facilitating determining the final illumination method. It is possible to select the appropriate illumination equipment taking into consideration location of luminaires which is directly depending on technical conditions

Architectural illumination of contemporary buildings

W artykule, na przykładzie budynku Collegium Novum w Poznaniu, opisano wybrane problemy związane z iluminacją współczesnych obiektów architektonicznych. W wielu przypadkach, twórca obiektu ma istotny wpływ na wybór ostatecznego rozwiązania oświetlenia fasady. Wskazano na istotną rolę wizualizacji komputerowej efektów plastycznych, możliwych do uzyskania, zależnie od przyjętych, technicznych rozwiązań oświetleniowych, dotyczących wyboru metody iluminacji, doboru rodzaju sprzętu oświetleniowego oraz sposobu montażu opraw. Porównanie wizualizacji różnych wariantów ułatwia podjęcie decyzji realizacyjnej.Chosen aspects of illumination concepts of contemporary buildings are described in the article. The computer visualizations of lighting variants and final solution of Collegium Novum illumination in Poznan are presented

Illumination of the contemporary architectural facilities and buildings

In the article, using as an example the Collegium Novum building in Poznań, there has been described selected problems connected with the illumination of modern architectonic facilities and building. In many cases, the author or designer of the building project has significant influence on selecting the final solution for the faęade illumination. There has been indicated the significant role of the computer visualization of the artistic effects. The visualization shows possible to obtain effects, dependently on applied technical illumination solutions. The effects depend on selected illumination method, selected illumination equipment as well as on the luminaires assembling methods. The comparison of various visualization versions facilitates taking the final decision for choosing the execution