Burning mouth syndrome as the initial sign of multiple myeloma

AbstractA 79-year-old women was referred to our Department with burning symptoms in the whole oral cavity together with clinically healthy appearence of the oral mucosa. Hematological tests as well as bone marrow biopsy revealed diagnosis of plasmocytoma. The aim of our case report was to underline the importance of hematological screening in patients with burning mouth syndrome

Oral Squamous Cell Carcinoma (OSCCA) Arising from an Oral Lichen Planus Lesion - Report of Two Cases

Rizik maligne transformacije oralnoga lichena planusa predmetom je mnogih rasprava i oprečnih stajališta u literaturi. Kronicitet oralnih lezija lichena nosi manji rizik za nastanak oralnoga karcinoma, a rizik za njegov nastanak veći je na već upaljenim, atrofičnim i erozivnim površinama oralnoga lichena. procjenjuje se da OLP maligno alterira u 0,4 - 2,5% slučajeva, pretežito onih s već prije dokazanom lichenoidnom displazijom. Novije molekularno genetičke studije pokazuju minimalne genetičke promjene u lezijama oralnoga lichena, a veće su promjene zabilježene u epitelnoj displaziji i malignim lezijama. Ovim radom želimo prikazati dva dobro dokumentirana slučaja oralnoga karcinoma koji se je razvio na bukalnoj sluznici u osoba s dugotrajnim oralnim lichenom. Prikazani slučajevi dokumentiraju i upozoravaju na prirodnu sklonost oralnoga lichena planusa malignoj alternaciji i ističu nužnost redovitih biopsija: inicijalne biopsije kod prvoga pregleda radi postavljanja dijagnoze i češćih kontrolnih biopsija tijekom kliničkoga praćenja lezija kako bi se pravodobno otkrile promjene koje upozoravaju na displaziju. S obzirom na to da OLP predstavlja rizičnu leziju, potrebne su i genetičke raščlambe određenim markerima.The risk of malignant transformation of oral lichen planus remains a controversial issue in the literature. Chronicity of oral lesions has been shown to present low risk of oral cancer which has been identified as arising from areas of erythematous atrophic and erosive lichen planus. It is estimated that malignant transformation of OLP occurs in 0.4 - 2.5% of cases, mostly those with lichenoid dysplasia. Recent molecular genetic studies showed minimal genetic deviation in lesions of oral lichen planus, while the epithelial dysplasia and alignant lesions have shown increased genetic alterations. We report two well-documented cases of long-standing oral lichen planus in which squamous cell carcinoma of the buccal mucosa occurred. Presented cases document and warn of the propensity of oral lichen planus to undergo malignant transformation and stresses the importance of regular histilogical follow up; biopsy at the initial visit to confirm the diagnosis and more frequent control biopsies during clinical follow up to assess histological changes that may represent dysplasia. As a lesion at risk malignant transformation, OLP also needs to be confirmed by use of genetic markers

Oral Squamous Cell Carcinoma (OSCCA) Arising from an Oral Lichen Planus Lesion - Report of Two Cases

Rizik maligne transformacije oralnoga lichena planusa predmetom je mnogih rasprava i oprečnih stajališta u literaturi. Kronicitet oralnih lezija lichena nosi manji rizik za nastanak oralnoga karcinoma, a rizik za njegov nastanak veći je na već upaljenim, atrofičnim i erozivnim površinama oralnoga lichena. procjenjuje se da OLP maligno alterira u 0,4 - 2,5% slučajeva, pretežito onih s već prije dokazanom lichenoidnom displazijom. Novije molekularno genetičke studije pokazuju minimalne genetičke promjene u lezijama oralnoga lichena, a veće su promjene zabilježene u epitelnoj displaziji i malignim lezijama. Ovim radom želimo prikazati dva dobro dokumentirana slučaja oralnoga karcinoma koji se je razvio na bukalnoj sluznici u osoba s dugotrajnim oralnim lichenom. Prikazani slučajevi dokumentiraju i upozoravaju na prirodnu sklonost oralnoga lichena planusa malignoj alternaciji i ističu nužnost redovitih biopsija: inicijalne biopsije kod prvoga pregleda radi postavljanja dijagnoze i češćih kontrolnih biopsija tijekom kliničkoga praćenja lezija kako bi se pravodobno otkrile promjene koje upozoravaju na displaziju. S obzirom na to da OLP predstavlja rizičnu leziju, potrebne su i genetičke raščlambe određenim markerima.The risk of malignant transformation of oral lichen planus remains a controversial issue in the literature. Chronicity of oral lesions has been shown to present low risk of oral cancer which has been identified as arising from areas of erythematous atrophic and erosive lichen planus. It is estimated that malignant transformation of OLP occurs in 0.4 - 2.5% of cases, mostly those with lichenoid dysplasia. Recent molecular genetic studies showed minimal genetic deviation in lesions of oral lichen planus, while the epithelial dysplasia and alignant lesions have shown increased genetic alterations. We report two well-documented cases of long-standing oral lichen planus in which squamous cell carcinoma of the buccal mucosa occurred. Presented cases document and warn of the propensity of oral lichen planus to undergo malignant transformation and stresses the importance of regular histilogical follow up; biopsy at the initial visit to confirm the diagnosis and more frequent control biopsies during clinical follow up to assess histological changes that may represent dysplasia. As a lesion at risk malignant transformation, OLP also needs to be confirmed by use of genetic markers

Combined semi-analytical and finite element approach for hydro structure interactions during sloshing impacts - "Sloshel project"

International audienceThe paper discusses the development of the combined semianalytical (fluid flow) and numerical FEM (structure) models for hydro structure interactions during the sloshing impacts in the tanks of the membrane type LNG carriers

Hydroelastic impacts in the tanks of LNG carriers

International audienc