71 research outputs found
Kondo Effects and Multipolar Order in the cubic PrTr2Al20 (Tr=Ti, V)
Our single crystal study reveals that PrTr2Al20 (Tr = Ti and V) provides the
first examples of a cubic {\Gamma}3 nonmagnetic ground doublet system that
shows the Kondo effect including a -ln T dependent resistivity. The {\Gamma}3
quadrupolar moments in PrV2Al20 induce anomalous metallic behavior through
hybridization with conduction electrons, such as T^{1/2} dependent resistivity
and susceptibility below ~ 20 K down to its ordering temperature T_O = 0.6 K.
In PrTi2Al20, however, quadrupoles are well-localized and exhibit an order at
T_O = 2.0 K. Stronger Kondo coupling in PrV2Al20 than in PrTi2Al20 suppresses
quadrupolar ordering, and instead promotes hybridization between the {\Gamma}3
doublet and conduction electrons, leading to most likely the quadrupolar Kondo
effect.Comment: 12 pages, 4 figure
Numerical Analysis of variation in mesh stiffness for Spur Gear Pair with Method of Phasing
Abstract Gearing assembly remains one of the major vibration sources in power transmissio
Physiological significance of the interleukin 1 receptor accessory protein
International audienc
Transport and Bioactivity of Cyanidin 3-Glucoside into the Vascular Endothelium.
Flavonoids are dietary components involved in decreasing oxidative stress in the vascular endothelium, and thus the risk of endothelial dysfunction. However, their very low concentrations in plasma place this role in doubt. Thus, a relationship between the effective intracellular concentration of flavonoids and their bioactivity needs to be assessed. This study examined the uptake of physiological concentrations of cyanidin 3-glucoside, a widespread dietary flavonoid, into the human vascular endothelial cells. Furthermore, the involvement of the membrane transporter bilitranslocase (TC #2.A.65.1.1) as the key underlying molecular mechanism for membrane transport was investigated by using purified anti-sequence antibodies binding at the extracellular domain of the protein. The experimental observations were carried out in isolated plasma membrane vesicles and intact endothelial cells from human endothelial cells (EA.hy926), and on the ischemia-reperfusion model in the isolated rat hearts. Cyanidin 3-glucoside was transported via bilitranslocase into endothelial cells, where it acted as a powerful intracellular antioxidant and a cardioprotective agent in the reperfusion phase after ischemia. These findings suggest that dietary flavonoids, in spite of their limited oral bioavailability and very low post-absorption plasma concentrations, may provide protection against oxidative stress-based cardiovascular diseases. Bilitranslocase, by mediating the cellular uptake of some flavonoids, is thus a key factor for their protective activity on the endothelial function
Transport and bioactivity of cyanidin 3-glucoside into the vascular endothelium
Flavonoids are dietary components involved in decreasing oxidative stress in the vascular endothelium, and thus the risk of endothelial dysfunction. However, their very low concentrations in plasma place this role in doubt. Thus, a relationship between the effective intracellular concentration of flavonoids and their bioactivity needs to be assessed. This study examined the uptake of
physiological concentrations of cyanidin 3-glucoside, a widespread dietary flavonoid, into the human vascular endothelial cells. Furthermore, the involvement of the membrane transporter bilitranslocase (TC #2.A.65.1.1) as the key underlying molecular mechanism for membrane transport was investigated by using purified anti-sequence antibodies binding at the extracellular domain of the
protein. The experimental observations were carried out in isolated plasma membrane vesicles and intact endothelial cells from human endothelial cells (EA.hy926), and on the ischemia-reperfusion model in the isolated rat hearts. Cyanidin 3-glucoside was transported via bilitranslocase into
endothelial cells, where it acted as a powerful intracellular antioxidant and a cardioprotective agent in the reperfusion phase after ischemia. These findings suggest that dietary flavonoids, in spite of their
limited oral bioavailability and very low post-absorption plasma concentrations, may provide protection against oxidative stress-based cardiovascular diseases. Bilitranslocase, by mediating the cellular uptake of some flavonoids, is thus a key factor for their protective activity on the endothelial function
- …