Cooperative protein transport in cellular organelles

Compartmentalization into biochemically distinct organelles constantly exchanging material is one of the hallmarks of eukaryotic cells. In the most naive picture of inter-organelle transport driven by concentration gradients, concentration differences between organelles should relax. We determine the conditions under which cooperative transport, i.e. based on molecular recognition, allows for the existence and maintenance of distinct organelle identities. Cooperative transport is also shown to control the flux of material transiting through a compartmentalized system, dramatically increasing the transit time under high incoming flux. By including chemical processing of the transported species, we show that this property provides a strong functional advantage to a system responsible for protein maturation and sorting.Comment: 9 pages, 5 figure

Living on the edge of chaos: minimally nonlinear models of genetic regulatory dynamics

Linearized catalytic reaction equations modeling e.g. the dynamics of genetic regulatory networks under the constraint that expression levels, i.e. molecular concentrations of nucleic material are positive, exhibit nontrivial dynamical properties, which depend on the average connectivity of the reaction network. In these systems the inflation of the edge of chaos and multi-stability have been demonstrated to exist. The positivity constraint introduces a nonlinearity which makes chaotic dynamics possible. Despite the simplicity of such minimally nonlinear systems, their basic properties allow to understand fundamental dynamical properties of complex biological reaction networks. We analyze the Lyapunov spectrum, determine the probability to find stationary oscillating solutions, demonstrate the effect of the nonlinearity on the effective in- and out-degree of the active interaction network and study how the frequency distributions of oscillatory modes of such system depend on the average connectivity.Comment: 11 pages, 5 figure

Toward an ecological aesthetics: music as emergence

In this article we intend to suggest some ecological based principles to support the possibility of develop an ecological aesthetics. We consider that an ecological aesthetics is founded in concepts as “direct perception”, “acquisition of affordances and invariants”, “embodied embedded perception” and so on. Here we will purpose that can be possible explain especially soundscape music perception in terms of direct perception, working with perception of first hand (in a Gibsonian sense). We will present notions as embedded sound, detection of sonic affordances and invariants, and at the end we purpose an experience with perception/action paradigm to make soundscape music as emergence of a self-organized system

Closing the Generalization Gap in One-Shot Object Detection

Despite substantial progress in object detection and few-shot learning, detecting objects based on a single example - one-shot object detection - remains a challenge: trained models exhibit a substantial generalization gap, where object categories used during training are detected much more reliably than novel ones. Here we show that this generalization gap can be nearly closed by increasing the number of object categories used during training. Our results show that the models switch from memorizing individual categories to learning object similarity over the category distribution, enabling strong generalization at test time. Importantly, in this regime standard methods to improve object detection models like stronger backbones or longer training schedules also benefit novel categories, which was not the case for smaller datasets like COCO. Our results suggest that the key to strong few-shot detection models may not lie in sophisticated metric learning approaches, but instead in scaling the number of categories. Future data annotation efforts should therefore focus on wider datasets and annotate a larger number of categories rather than gathering more images or instances per category

Kaufverhaltensrelevante Effekte des Konsumentenvertrauens im Internet: Eine vergleichende Analyse von Online-Händlern

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