Validity and reliability of the Structured Clinical Interview for Depersonalization-Derealization Spectrum (SCI-DER).

This study evaluates the validity and reliability of a new instrument developed to assess symptoms of depresonalization: the Structured Clinical Interview for the Depersonalization-Derealization Spectrum (SCI-DER). The instrument is based on a spectrum model that emphasizes soft-signs, sub-threshold syndromes as well as clinical and subsyndromal manifestations. Items of the interview include, in addition to DSM-IV criteria for depersonalization, a number of features derived from clinical experience and from a review of phenomenological descriptions. Study participants included 258 consecutive patients with mood and anxiety disorders, 16.7% bipolar I disorder, 18.6% bipolar II disorder, 32.9% major depression, 22.1% panic disorder, 4.7% obsessive compulsive disorder, and 1.5% generalized anxiety disorder; 2.7% patients were also diagnosed with depersonalization disorder. A comparison group of 42 unselected controls was enrolled at the same site. The SCI-DER showed excellent reliability and good concurrent validity with the Dissociative Experiences Scale. It significantly discriminated subjects with any diagnosis of mood and anxiety disorders from controls and subjects with depersonalization disorder from controls. The hypothesized structure of the instrument was confirmed empirically

Toward measuring the spin of obscured supermassive black holes: A critical assessment with disk megamasers

Context. Mass and spin are two fundamental properties of astrophysical black holes. While some established indirect methods are adopted to measure both these properties of active galactic nuclei (AGN) when viewed relatively face-on, very few suggested methods exist to measure these properties when AGN are highly inclined and potentially obscured by large amounts of gas. Aims. In this context we explore the accuracy and performance of a recently proposed method to estimate the spin of AGN by fitting the accretion disk spectral energy distribution, when adapted for highly inclined and obscured systems, and in particular to a sample of six local water megamasers. For these sources the accretion rate and inclination angle are both known, allowing us to rely only on the AGN bolometric luminosity to infer their spin. Methods. Using the bolometric luminosity as a proxy for the accretion disk peak luminosity, we derived the expected bolometric luminosity as a function of spin. Then, we measured the bolometric luminosity of each source through X-ray spectroscopy, and compared it with the expected value to constrain the spin of the AGN. Results. The quality of the constraints depend critically on the accuracy of the measured bolometric luminosity, which is difficult to estimate in heavily obscured systems. Three out of six sources do not show consistency between the expected and measured bolometric luminosities, while the other three (four, when considering the [OIII] line as tracer of the bolometric luminosity) are formally consistent with high spin values. Conclusions. Our results suggest that this method, although promising (and possibly considered as a future calibrator for other methods) needs better observational data and further theoretical modeling to be successfully applied to obscured AGN and to infer robust results

The compositional and mineralogical analysis of fired pigments in Nasca pottery from Cahuachi (Peru) by the combined use of the portable PIXE-alpha and portable XRD techniques

Abstract An analytical protocol based on the combined use of the portable PIXE-alpha (Particle Induced X-ray Emission) and XRD (X-ray Diffraction) non destructive techniques developed at the LANDIS laboratory (Laboratorio di Analisi Non Distruttive) of the INFN–CNR (Istituto Nazionale di Fisica Nucleare–Consiglio Nazionale delle Ricerche) in Catania (Italy), was applied for the characterisation of the surface paints of some archaeological fragments of Nasca pottery from the Ceremonial Centre of Cahuachi in Southern Peru. Measurements were carried out on the black, white, red, orange and grey pigments; quantitative information on the chemical composition as well as on the mineralogical phases present on the paints were obtained. Results allowed to make some considerations about the materials and the manufacturing technique used to realise such fired pigments. It should be noted that during firing the precursor minerals composing the pigments undergo a phase transformation and their identification presents some difficulties

Exceptional response to immunotherapy in association with radiotherapy in patient with breast metastasis from urothelial carcinoma: A case report

Most common sites of metastasis of urothelial carcinoma (UC) are lungs, liver, lymph nodes and bone. Pembrolizumab, a humanized monoclonal antibody directed against programmed cell death protein-1 (PD-1), represents an effective second-line therapy for advanced UC. Radiotherapy has been shown to induce a mechanism of immunogenic cell death (ICD) resulting in immune memory and advantageous systemic effects. We present the first case of breast metastasis (BM) from a UC described in literature who had an exceptional response to second-line therapy with pembrolizumab in association with radiotherapy, showing the efficacy of combining immunotherapy and radiotherapy even in patients with atypical metastatic sites

Targeted next-generation sequencing for the identification of genetic predictors of radiation-induced late skin toxicity in breast cancer patients: A preliminary study

Normal tissue radiosensitivity is thought to be influenced by an individual’s genetic back-ground. However, the specific genetic variants underlying the risk of late skin reactions following radiotherapy for breast cancer remain elusive. To unravel the genetic basis for radiation-induced late skin toxicity, we carried out targeted next-generation sequencing of germline DNA samples from 48 breast cancer patients with extreme late skin toxicity phenotypes, consisting of 24 cases with grade 2–3 subcutaneous fibrosis and/or grade 2–3 telangiectasia (LENT-SOMA scales) and 24 controls with grade 0 fibrosis and grade 0 telangiectasia. In this exploratory study, a total of five single-nucleotide variants (SNVs) located in three genes (TP53, ERCC2, and LIG1) reached nominal levels of statistical significance (p C, Pro72Arg) in the replication cohort had an effect (OR per C allele: 1.52, 95%CI: 0.82–2.83, p = 0.186) in the same direction as in the exploratory cohort (OR per C allele: 4.70, 95%CI: 1.51–14.6, p = 0.007) and was found be nominally associated to the risk of radiation-induced late skin toxicity in the overall combined cohort (OR per C allele: 1.79, 95%CI: 1.06–3.02, p = 0.028). These results raise the possibility of an association between TP53 rs1042522 and risk of radiation-induced late skin toxicity in breast cancer patients; however, large replication studies are warranted for conclusive evidence

Analysis of a civil aircraft wing transonic shock buffet experiment

The physical mechanism governing the onset of transonic shock buffet on swept wings remains elusive, with no unequivocal description forthcoming despite over half a century of research. This paper elucidates the fundamental flow physics on a civil aircraft wing using an extensive experimental database from a transonic wind tunnel facility. The analysis covers a wide range of flow conditions at a Reynolds number of around . Data at pre-buffet conditions and beyond onset are assessed for Mach numbers between 0.70 and 0.84. Critically, unsteady surface pressure data of high spatial and temporal resolution acquired by dynamic pressure-sensitive paint is analysed, in addition to conventional data from pressure transducers and a root strain gauge. We identify two distinct phenomena in shock buffet conditions. First, we highlight a low-frequency shock unsteadiness for Strouhal numbers between 0.05 and 0.15, based on mean aerodynamic chord and reference free stream velocity. This has a characteristic wavelength of approximately 0.8 semi-span lengths (equivalent to three mean aerodynamic chords). Such shock unsteadiness is already observed at low-incidence conditions, below the buffet onset defined by traditional indicators. This has the effect of propagating disturbances predominantly in the inboard direction, depending on localised separation, with a dimensionless convection speed of approximately 0.26 for a Strouhal number of 0.09. Second, we describe a broadband higher-frequency behaviour for Strouhal numbers between 0.2 and 0.5 with a wavelength of 0.2 to 0.3 semi-span lengths (0.6 to 1.2 mean aerodynamic chords). This outboard propagation is confined to the tip region, similar to previously reported buffet cells believed to constitute the shock buffet instability on conventional swept wings. Interestingly, a dimensionless outboard convection speed of approximately 0.26, coinciding with the low-frequency shock unsteadiness, is found to be nearly independent of frequency. We characterise these coexisting phenomena by use of signal processing tools and modal analysis of the dynamic pressure-sensitive paint data, specifically proper orthogonal and dynamic mode decomposition. The results are scrutinised within the context of a broader research effort, including numerical simulation, and viewed alongside other experiments. We anticipate our findings will help to clarify experimental and numerical observations in edge-of-the-envelope conditions and to ultimately inform buffet-control strategies