Study of maternal and fetal outcome in eclampsia at Government Medical college, Aurangabad, Maharashtra, India

Background: Eclampsia is an obstetric enigma. Eclampsia as a clinical entity has been known from times immemorial. Even today it is one of the dreaded complications. Today also eclampsia is a life-threatening emergency that continues to be a major cause of serious maternal and perinatal morbidity and it’s still the leading cause of maternal mortality in our country.Methods: Method analysis of case records of all eclampsia cases from study period of October 2013 to September 2015, a observational study.Results: The incidence of eclampsia was found to be 1.06% in GMC, Aurangabad. The number of maternal deaths of eclampsia patients was 7 out of 335 eclampsia cases. Maternal mortality in eclampsia patients was 2.08% in 2-year study, however maternal mortality in hospital was 0.23% in 2 years study and the perinatal mortality rate in eclampsia was 361 per 1000 total births. while it is 84 per 1000 total birth for total deliveries in GMC Aurangabad during study. Majority of patients i.e. 87.75% were in the age group of 16-25 years, 55.82% of total eclampsia were primigravida 57% eclampsia cases were referred from government or private hospitals, 11% booked in GMC and 32% patients were self.  Antepartum eclampsia was the commonest type 82.11%. 80% patients of eclampsia were delivered vaginally and 18% underwent caesarean section ,2% instrumental deliveries. 12% of babies had birth weight 1000gm. 41% babies delivered with weight 2001 gm. Out of 264 live births 92 babies required NICU admission and 45 babies died in early neonatal period.Conclusions: With good antenatal, intranatal and postnatal care with judicious use of anti-hypertensive, anti-convulsant and battery of investigations and judicious obstetric intervention, maternal and perinatal mortality can be reduced

PRESERVATION OF PANEER BY USING PVC CLING FILM

Paneer is a popular indigenous variety of soft cheese in India and used as a base material for the preparation of a large number of culinary dishes. Paneer, like other indigenous products is highly ±perishable. At room temperature it cannot be stored more than a day and under refrigeration it may remain acceptable for six days. Therefore, study was undertaken to give a comprehensive package by application of sorbic acid and PVC cling film. It is observed that paneer could be stored safely up to 13 days at 7±ºC by adapting hygienic practices of manufacturing and wrapping during it in PVC cling film. Use of 0.1% sorbic acid alone could be recommended along with wrapping of paneer in cling film to extend its storage life up to 33 days in refrigeration (7±ºC ) and for 3 days at room temperature. There was reduction in moisture content but rise in titratable acidity, FFA, peroxide value and soluble nitrogen in treated paneer during storage at both the temperatures.Â

EFFECTIVE MANAGEMENT OF ODONTOGENIC INFECTIONS THROUGH CONTROLLED FASHION BY POLYMERIC DEVICE CONTAINING MOXYFLOXACIN

Objective: Present work demonstrates the use of film that releases the drug at a pre-programmed manner. Several methods have been explored for management of moxifloxacin in dealing of Odontogenic infections which are mainly caused by necrotic pulp or by bacterial invasion from the periodontal tissue. These are usually mixed bacterial infections, and they penetrate mostly into the soft and bony oromaxillofacial tissues to produce submucosal infiltrates and abscesses.Methods: The films were developed with the intention to minimize the dose of a drug, to deliver definite concentration and to preserve dosage at its site for a longer period by this means gets a better patient compliance. Moxifloxacin films were prepared by solvent casting technique using gellan gum at different concentrations and PEG 400 as plasticizers. Compatibility study such as FT-IR and DSC also performed to check the interaction between drug and excipients used. The formulations were evaluated for their thickness, weight uniformity, folding endurance, content uniformity, surface pH, In vitro drug release. Optimized formulations were subjected to in vitro antibacterial activity and stability studies to assess the effectiveness of the formulations.Results: Formulations shown the good uniformity of drug content, there was no any kind of effect on moisture loss test. Weight and thickness of the films were found to be uniform. Plasticizer like PEG400 was found to influence their effect on drug release as well as characteristics of films.Conclusion: In vitro studies revealed that the formulations provide the best alternative to prolong drug release at the end of 10 h and formulations remained stable with intact at ambient conditions.Â

Studies on Preparation of Quarg Type Cheese From Cow Milk and Goat Milk

The current upward trend in nutritional and health awareness is the consumer’s demands for high nutritive valuable product in the market with acceptable sensory characteristics. The present study was carried out to explore the possibilities of using goat milk alone and in combination with cow milk for preparation of quarg type cheese. The levels of cow milk and goat milk treatments were T1, T2, T3, T4 and T5 as 100:00, 75:25, 50:50, 25:75 and 00:100 per cent  respectively. The product was served to the semi-trained panel of judges to know its acceptability. The treatment T3 having 50% cow milk and 50% goat milk was rated superior amongst experimental treatments. In respect of chemical composition protein, moisture and acidity were increased with increased in level of goat milk while fat, carbohydrate, total solid ash and pH were decreased with increased in level of goat milk

Extraction of sunnhemp fibre and its properties

An effort has been made to extract sunnhemp fibre from stalks of sunnhemp plants which are considered as agriculture waste after harvesting seeds. Sunnhemp (Crotalaria junceae) stalks have been rippled and stacked for about 20-30 days to dry the stalks. The dried stalks are then pre-treated with different retting agents, viz. urea and compost culture. Fibre is extracted by water retting (tank) method. Physico-chemical properties, microstructure and solubility tests of extracted sunnhemp fibre are performed. It is revealed that the urea treated stalks produce higher fibre yield with lower retting period. Urea treated sunnhemp stalks give relatively longer, finer and stronger fibres than the compost culture treated and control stalks. Lower per cent of lignin is observed in compost culture treated stalks. Sunnhemp fibre constitutes oblong shaped cross-section with elongated lumen. Like cellulosic fibres, sunnhemp fibre is soluble in concentrated acids and is least affected by solvents

Learning internal iliac artery ligation and pelvic ureter course through cadaveric dissections

Background: Few surgical procedures, although vital, are not learnt and mastered during postgraduate courses in Obstetrics and Gynecology. Internal iliac artery ligation and tracing course of ureter are few of such surgical procedures. Cadaveric dissection sessions organized during postgraduate courses and as CME sessions (continued medical education) have proved useful in learning such unlearnt procedures. This article shares experiences from teaching internal iliac artery ligation, pelvic ureter course tracing and principles of many other unusual gynaecological surgical procedures to Obstetrics and Gynecology specialists and postgraduate students through CME programs involving cadaveric dissection.Methods: This involved organizing and conducting four cadaveric dissection CME workshops at three different teaching institutions. The components of these CMEs were lectures with power point presentations and two-way audio-visual interactive sessions while pelvic anatomy was demonstrated on cadavers through live dissections. Each CME was concluded by tactile experience to each delegate by handling the dissected cadavers; this was made possible by limiting delegate registration to 50 at each CME.Results: The surgical skills of internal iliac artery ligation and tracing course of pelvic ureter, which are not adequately and confidently learnt in routine postgraduate tenure, could be effectively transferred through cadaveric dissection.Conclusions: Revisiting anatomy dissection halls helps in learning rare but lifesaving surgical techniques. This can be achieved by arranging cadaveric dissection CMEs for practicing specialists. Such CMEs should be organized regularly and should be integrated into postgraduate curriculum

Synthesis and biological evaluation of novel 3-aryl-4-methoxy N-alkyl maleimides

473-478In the present investigation, a series of 3-aryl-4-methoxy N-alkyl maleimide 5a-l have been synthesized and screened for their antimicrobial activity against one Gram positive bacteria (S. aureus), one Gram negative bacteria (E. coli) and fungal strains (C. albicans, C. tropicalis,  A. niger and A. clavatus). The structures of the compounds have been substantiated by their IR, NMR, mass and elemental analysis. The minimum inhibitory concentrations (MICs) of synthesized maleimides have been determined by broth microdilution method. Of the newly synthesized maleimides, compounds 5c, 5f, 5h, 5i, 5k and 5l registered significant activity against the tested microorganisms