Recover:designing a videogame to assist with recovery from PTSD

Recover is a game prototype that was developed to explore the potential of videogames to provide users recovering from PTSD with an alternative form of immersive self-help. The game is presented as a playable concept that focuses on mindfulness techniques whilst aiming to engage and retain users. The concept also includes a companion application for mobile, whilst the main videogame has been designed for use with Virtual Reality (VR) headsets

Digital analysis of Potomac River Basin ERTS imagery: Sedimentation levels at the Potomac-Anacostia confluence and strip mining in Allegheny County, Maryland

Two simple algorithms for classification of sedimentation levels in water and for delineation of active strip mines are in use as part of the development of a more general resource management information system. ERTS MSS CCT's are processed so that each pixel in each channel is geographically referenced and can be accessed individually during whole frame, multi-channel analysis or partial frame analysis. The sedimentation analysis clearly separates classes representing the turbid Anacostia water, the less disturbed Potomac (really), and mud flats resulting from effluent of a major sewage treatment plant. Mud flats of organic or mineral origin are easily distinguished

Determining trophic niche width: a novel approach using stable isotope analysis

1. Although conceptually robust, it has proven difficult to find practical measures of niche width that are simple to obtain, yet provide an adequate descriptor of the ecological position of the population examined. 2. Trophic niche has proven more tractable than other niche dimensions. However, indices used as a proxy for trophic niche width often suffer from the following difficulties. Such indices rarely lie along a single scale making comparisons between populations or species difficult; have difficulty in combining dietary prey diversity and evenness in an ecologically meaningful way; and fail to integrate diet over ecological time-scales thus usually only comprise single snapshots of niche width. 3. We propose an alternative novel method for the comparison of trophic niche width: the use of variance of tissue stable isotope ratios, especially those of nitrogen and carbon. 4. This approach is a potentially powerful method of measuring trophic niche width, particularly if combined with conventional approaches, because: it provides a single measure on a continuous axis that is common to all species; it integrates information on only assimilated prey over time; the integration period changes with choice of tissue sampled; and data production is theoretically fast and testing among populations simple. 5. Empirical studies are now required to test the benefits of using isotopic variance as a measure of niche width, and in doing so help refine this approach

A fully-coherent all-sky search for gravitational-waves from compact binary coalescences

We introduce a fully-coherent method for searching for gravitational wave signals generated by the merger of black hole and/or neutron star binaries. This extends the coherent analysis previously developed and used for targeted gravitational wave searches to an all-sky, all-time search. We apply the search to one month of data taken during the fifth science run of the LIGO detectors. We demonstrate an increase in sensitivity of 25% over the coincidence search, which is commensurate with expectations. Finally, we discuss prospects for implementing and running a coherent search for gravitational wave signals from binary coalescence in the advanced gravitational wave detector data.Comment: 17 pages, 12 figure

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease

Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main pathological features of AD is the presence in the brain of senile plaques mainly composed of aggregated β amyloid (Aβ), a derivative of the longer amyloid precursor protein (APP). The amyloid hypothesis proposes that the accumulation of Aβ within neural tissue is the initial event that triggers the disease. Here we review research efforts that have attempted to inhibit the generation of the Aβ peptide through modulation of the activity of the proteolytic secretases that act on APP and discuss whether this is a viable therapeutic strategy for treating AD.<p></p> Alzheimer's disease (AD) is the most common form of dementia in the elderly but as yet there are no drugs that can halt the progression of this disease. In a theory called the ‘amyloid hypothesis’, researchers have proposed that the accumulation of a small protein fragment called beta amyloid or Aβ within brain tissue is the event which triggers Alzheimer's disease. Aβ is a derivative of the longer amyloid precursor protein (APP). Here we review research efforts that have attempted to inhibit the generation of Aβ through modulation of proteins called secretases which cut APP into Aβ. Author edits made on: 20 May 2015

Electro-optic bunch diagnostics on ALICE

An electro-optic longitudinal bunch profile monitor has been implemented on ALICE (Accelerators and Lasers in Combined Experiments) at the Daresbury Laboratories and will be used both to characterise the electron bunch and to provide a testbed for electro-optic techniques. The electro-optic station is located immediately after the bunch compressor, within the FEL cavity; its location allows nearby OTR, beam profile monitors and Coherent Synchrontron Radiation (CSR) diagnostics to be used for calibration and benchmarking. We discuss the implementation and the planned studies on electro-optic diagnostics using this diagnostic station

Physical and chemical stability of docetaxel infusions in polyolefin bags containing 0.9% soduim chloride or 5% glucose at 5 ͦC and 25 ͦC

Study objectives: To investigate the long-term physical and chemical stability of 0.3 mg/mL and 0.7 mg/mL infusions of docetaxel (Teva) in polyolefin bags containing either 0.9% sodium chloride or 5% glucose, stored under refrigerated (2°C–8°C) and room temperature (25°C) conditions protected from the light. Methods: The infusions were prepared aseptically and stored at the two temperatures for 56 days. At various time points, chemical stability was determined using a validated stability-indicating, high performance liquid chromatography (HPLC) assay. Physical stability was ascertained in terms of visual appearance, pH, weight change of infusions, and sub-visible particles counts. Results: Irrespective of drug concentration, diluent type, or storage temperature, docetaxel infusions were compliant with both physical and chemical acceptance criteria over the 56-day study period. Conclusion: This study has demonstrated the extended stability of docetaxel (Teva) infusions over the concentration range 0.3–0.7 mg/mL in polyolefin bags containing either 0.9% sodium chloride or 5% glucose and stored at either 2°C–8°C or 25°C. These findings will enable pre-preparation and storage of these infusions by Centralised Intravenous Additive Services (CIVAS) units and the application of dose-banding schemes. As with all infusions where physical stability is potentially limited, docetaxel infusions should be carefully inspected for precipitation both before and during use irrespective of the storage period before use

Scottish theme towns: have new identities enhanced development?

Three small towns in southwest Scotland have recently been branded as distinct theme towns, based on books, artists and food. This is an attempt to make them more attractive to visitors and thereby improve their economy. The objective of this research is to establish whether the new identities possessed by the towns have enhanced their development. It is argued, using data reviewing the past decade, that they have all developed, albeit at different rates, in terms of the economy and culture. Moreover, it is maintained that social capital has been enhanced and is a factor whose importance has been under-appreciated by planners and observers of this type of process. The relevance of the new identity to the pre-branding identity is also seen as a factor in successful development and ideas of authenticity and heritage are brought to bear on the relationship