4,706 research outputs found
Metal chelates as anti-cancer agents. II cytotoxic action of palladium and platinum complexes of 6-mercaptopurine and thioguanine.
The metal complexes Pd(MP)2.2H2O, Pt(MP)2H2O (MPH=6-mercaptopurine), Pt(AMP2.3H2O and Pd3(AMP)4Cl2(AMPH).4H2O (AMPH=thioguanine) have been isolated. They were screened for anti-tumour activity in the L-1210 lymphoid leukaemia test system in mice. All 4 show marked anti-tumour activity, the complex Pt(AMP)2.3H2O giving a T/C of 185 at the optimum dosage. However, the anti-tumour activity of the metal complexes is somewhat less than that shown by the parent purines under the same conditions
A Survey of 56 Mid-latitude EGRET Error Boxes for Radio Pulsars
We have conducted a radio pulsar survey of 56 unidentified gamma-ray sources
from the 3rd EGRET catalog which are at intermediate Galactic latitudes (5 deg.
< |b| < 73 deg.). For each source, four interleaved 35-minute pointings were
made with the 13-beam, 1400-MHz multibeam receiver on the Parkes 64-m radio
telescope. This covered the 95% error box of each source at a limiting
sensitivity of about 0.2 mJy to pulsed radio emission for periods P > 10 ms and
dispersion measures < 50 pc cm-3. Roughly half of the unidentified gamma-ray
sources at |b| > 5 deg. with no proposed active galactic nucleus counterpart
were covered in this survey. We detected nine isolated pulsars and four
recycled binary pulsars, with three from each class being new. Timing
observations suggest that only one of the pulsars has a spin-down luminosity
which is even marginally consistent with the inferred luminosity of its
coincident EGRET source. Our results suggest that population models, which
include the Gould belt as a component, overestimate the number of isolated
pulsars among the mid-latitude Galactic gamma-ray sources and that it is
unlikely that Gould belt pulsars make up the majority of these sources.
However, the possibility of steep pulsar radio spectra and the confusion of
terrestrial radio interference with long-period pulsars (P > 200 ms) having
very low dispersion measures (< 10 pc cm-3, expected for sources at a distance
of less than about 1 kpc) prevent us from strongly ruling out this hypothesis.
Our results also do not support the hypothesis that millisecond pulsars make up
the majority of these sources. Non-pulsar source classes should therefore be
further investigated as possible counterparts to the unidentified EGRET sources
at intermediate Galactic latitudes.Comment: 24 pages, including 4 figures and 3 tables. Accepted for publication
in Ap
Planning for residential ‘value’? London’s densification policies and impacts
This paper considers the agency and influence of planning processes and densification policies on urban landscapes in London. Urban transformation through residential densification can bring opportunities for real estate development, combined with longer term investment and financial gains for local authorities through planning gain. However, the measurements and indicators used to define density and its impacts could be better understood both objectively and subjectively through the lens of an extended notion of ‘value’. Such experiences of density can be viewed bluntly as positive or negative. This research investigates nuanced dimensions of density and adopts a primarily qualitative approach, reflecting on relevant literature and wider policy context through a discourse analysis relating to densification in London. The idea of elements of ‘value’ is explored and evaluated in ongoing developments through a detailed case study of Nine Elms, London. Quantitative data on the residential real estate market is used to illustrate investment flows. Conclusions consider best practice policy recommendations in relation to understandings of ‘value’
Physical activity patterns in a nationally representative sample of adults in Ireland
Original article can be found at: http://journals.cambridge.org/ Copyright - the authors. DOI: 10.1079/PHN2001192Objective To evaluate habitual levels of physical activity in a nationally representative sample of adults in Ireland. Design Cross-sectional survey using a self-administered questionnaire. Usual levels of work, recreational and household activities were evaluated in relation to anthropometric, demographic and socio-economic characteristics. The amount and intensity of all activities were quantified by assigning metabolic equivalents (METS) to each activity. Setting Republic of Ireland and Northern Ireland, 1997–1999. Subjects Random sample of 1379 adults aged 18–64 years. Results Men were approximately twice as active in work and recreational activity (139.7 ± 83.9 METS) as women (68.5 ± 49.8 METS; P 28kg m−2) or obese (BMI > 30kg m−2). Fewer obese subjects reported higher levels of work and leisure activities. However, a higher percentage of obese women reported participation in the higher levels of household activities. Participation rates in recreational activities were low. Walking was the most important leisure activity of both men (41%) and women (60%). In terms of hours per week spent in vigorous physical activity, men were more active than women, professional and skilled non-manual women were more active than women in other social classes, and younger subjects (aged 18–35 years) were more active than older subjects. Conclusions The holistic approach used in the assessment of physical activity in this study has revealed important and subtle differences in the activity patterns of men and women. Failure to fully characterise the respective activity patterns of men and women could lead to ill-informed public health policy aimed at promoting and sustaining lifetime habits of physical activity. The results suggest that simple population-focused programmes to promote physical activity are unlikely to offer the same chance of long-term success as more sensitive and individualised strategies.Peer reviewe
No detectable radio emission from the magnetar-like pulsar in Kes 75
The rotation-powered pulsar PSR J1846-0258 in the supernova remnant Kes 75
was recently shown to have exhibited magnetar-like X-ray bursts in mid-2006.
Radio emission has not yet been observed from this source, but other
magnetar-like sources have exhibited transient radio emission following X-ray
bursts. We report on a deep 1.9 GHz radio observation of PSR J1846-0258 with
the 100-m Green Bank Telescope in late 2007 designed to search for radio
pulsations or bursts from this target. We have also analyzed three shorter
serendipitous 1.4 GHz radio observations of the source taken with the 64-m
Parkes telescope during the 2006 bursting period. We detected no radio emission
from PSR J1846-0258 in either the Green Bank or Parkes datasets. We place an
upper limit of 4.9 \mu Jy on coherent pulsed emission from PSR J1846-0258 based
on the 2007 November 2 observation, and an upper limit of 27 \mu Jy around the
time of the X-ray bursts. Serendipitously, we observed radio pulses from the
nearby RRAT J1846-02, and place a 3\sigma confidence level upper limit on its
period derivative of 1.7 * 10^{-13}, implying its surface dipole magnetic field
is less than 2.6 * 10^{13} G.Comment: 15 pages, 2 figures, submitted to Ap
Pulsar magnetic alignment and the pulsewidth-age relation
Using pulsewidth data for 872 isolated radio pulsars we test the hypothesis
that pulsars evolve through a progressive narrowing of the emission cone
combined with progressive alignment of the spin and magnetic axes. The new data
provide strong evidence for the alignment over a time-scale of about 1 Myr with
a log standard deviation of around 0.8 across the observed population. This
time-scale is shorter than the time-scale of about 10 Myr found by previous
authors, but the log standard deviation is larger. The results are inconsistent
with models based on magnetic field decay alone or monotonic counter-alignment
to orthogonal rotation. The best fits are obtained for a braking index
parameter n_gamma approximately equal to 2.3, consistent the mean of the six
measured values, but based on a much larger sample of young pulsars. The
least-squares fitted models are used to predict the mean inclination angle
between the spin and magnetic axes as a function of log characteristic age.
Comparing these predictions to existing estimates it is found that the model in
which pulsars are born with a random angle of inclination gives the best fit to
the data. Plots of the mean beaming fraction as a function of characteristic
age are presented using the best-fitting model parameters.Comment: 13 pages, 11 figures, Accepted for publication in MNRA
Researching the Ends of Identity: Birth and Death on Social Media
This paper argues that expanding the scope of social media studies to examine birth and early life at one end, and death and memorialisation at the other, demonstrates that social media is never just about an individual, but also the way individuals are always already joined together as families, groups, communities and more. Mapping these ends of identity also reveals more of the nuances of everyday social media use and its impact
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