42,247 research outputs found

    Immunoreactivity for a calmodulin-dependent protein kinase is selectively increased in macaque striate cortex after monocular deprivation

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    Immunocytochemical methods were used to localize type II Ca2+/calmodulin-dependent protein kinase in the macaque primary visual cortex. Neurons that stain for the kinase include both pyramidal and nonpyramidal cells and they appear to form a subset of cortical neurons. They are densely packed in layers II and IVB, somewhat more sparse in layers III, IVCß, and VI, and nearly absent in layer V. In normal animals the distribution of kinase-positive cells within each layer is relatively uniform. However, in animals in which one eye is removed 7-14 days before sacrifice or sutured shut for 9 or 11 weeks, the cells in layer IVCß are divided into alternating lightly and darkly stained bands. Comparison of immunocytochemically stained sections with adjacent sections stained for the mitochondrial enzyme, cytochrome oxidase, reveals that the kinase staining increases in ocular dominance columns originally driven by the removed or closed eye. These findings suggest that either the concentration of type II Ca2+/calmodulin-dependent protein kinase or its accessibility to the antibody probe increases dramatically and selectively in neurons of macaque primary visual cortex that have been deprived of their normal visual input. This may indicate that changing levels of activity in cortical neurons can alter their regulatory machinery

    Effect of a Spin-1/2 Impurity on the Spin-1 Antiferromagnetic Heisenberg Chain

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    Low-lying excited states as well as the ground state of the spin-1 antiferro- magnetic Heisenberg chain with a spin-1/2 impurity are investigated by means of a variational method and a method of numerical diagonalization. It is shown that 1) the impurity spin brings about massive modes in the Haldane gap, 2) when the the impurity-host coupling is sufficiently weak, the phenomenological Hamiltonian used by Hagiwara {\it et al.} in the analysis of ESR experimental results for NENP containing a small amount of spin-1/2 Cu impurities is equivalent to a more realistic Hamiltonian, as far as the energies of the low-lying states are concerned, 3) the results obtained by the variational method are in semi-quantitatively good agreement with those obtained by the numerical diagonalization.Comment: 11 pages, plain TeX (Postscript figures are included), KU-CCS-93-00

    Theology at the coal-face of hospitalisation - the development and evaluation of a postgraduate certificate in Healthcare Chaplaincy

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    Healthcare chaplaincy is working towards recognition as a registered health profession. An accredited programme of professional education is part of that process. The University of Glasgow supported by NHS Education for Scotland have developed a programme of professional education for healthcare chaplains that is integrated into an MSc. (MedSci) in healthcare. This article outlines the commissioning, development and evaluation of a postgraduate certificate in healthcare chaplaincy by students, clinical mentors and experienced healthcare chaplains. It also highlights an innovative approach to practice development in spiritual and religious care in healthcare

    Planet formation around stars of various masses: Hot super-Earths

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    We consider trends resulting from two formation mechanisms for short-period super-Earths: planet-planet scattering and migration. We model scenarios where these planets originate near the snow line in ``cold finger'' circumstellar disks. Low-mass planet-planet scattering excites planets to low periastron orbits only for lower mass stars. With long circularisation times, these planets reside on long-period eccentric orbits. Closer formation regions mean planets that reach short-period orbits by migration are most common around low-mass stars. Above ~1 Solar mass, planets massive enough to migrate to close-in orbits before the gas disk dissipates are above the critical mass for gas giant formation. Thus, there is an upper stellar mass limit for short-period super-Earths that form by migration. If disk masses are distributed as a power law, planet frequency increases with metallicity because most disks have low masses. For disk masses distributed around a relatively high mass, planet frequency decreases with increasing metallicity. As icy planets migrate, they shepherd interior objects toward the star, which grow to ~1 Earth mass. In contrast to icy migrators, surviving shepherded planets are rocky. Upon reaching short-period orbits, planets are subject to evaporation processes. The closest planets may be reduced to rocky or icy cores. Low-mass stars have lower EUV luminosities, so the level of evaporation decreases with decreasing stellar mass.Comment: Accepted to ApJ. 13 pages of emulateap

    Development of the health and economic consequences of smoking interactive model

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    Objective-To describe the health and economic consequences of smoking model, a user friendly, web based tool, designed to estimate the health and economic outcomes associated with smoking and the benefits of smoking cessation. Results-An overview of the development of the model equations and user interface is given, and data from the UK are presented as an example of the model outputs. These results show that a typical smoking cessation strategy costs approximately pound 1200 per life year saved and pound 22 000 per death averted. Conclusions-The model successfully captures the complexity required to model smoking behaviour and associated mortality, morbidity, and health care costs. Furthermore, the interface provides the results in a simple and flexible way so as to be useful to a variety of audiences and to simulate a variety of smoking cessation methods

    Baseline design of the filters for the LAD detector on board LOFT

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    The Large Observatory for X-ray Timing (LOFT) was one of the M3 missions selected for the phase A study in the ESA's Cosmic Vision program. LOFT is designed to perform high-time-resolution X-ray observations of black holes and neutron stars. The main instrument on the LOFT payload is the Large Area Detector (LAD), a collimated experiment with a nominal effective area of ~10 m 2 @ 8 keV, and a spectral resolution of ~240 eV in the energy band 2-30 keV. These performances are achieved covering a large collecting area with more than 2000 large-area Silicon Drift Detectors (SDDs) each one coupled to a collimator based on lead-glass micro-channel plates. In order to reduce the thermal load onto the detectors, which are open to Sky, and to protect them from out of band radiation, optical-thermal filter will be mounted in front of the SDDs. Different options have been considered for the LAD filters for best compromise between high quantum efficiency and high mechanical robustness. We present the baseline design of the optical-thermal filters, show the nominal performances, and present preliminary test results performed during the phase A study.Comment: Proc. SPIE 9144, Space Telescopes and Instrumentation 2014: Ultraviolet to Gamma Ray, 91446
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