The influence of primary Cu6Sn5 size on the shear impact properties of Sn-Cu/Cu BGA Joints

A method is presented to control the size of primary Cu6Sn5 in ball grid array (BGA) joints while keeping all other microstructural features near-constant, enabling a direct study of the size of primary Cu6Sn5 on impact properties. For Sn-2Cu/Cu BGA joints, it is shown that larger primary Cu6Sn5 particles have a clear negative effect on the shear impact properties. Macroscopic fracture occurred by a combination of the brittle fracture of embedded primary Cu6Sn5 rods and ductile fracture of the matrix βSn. Cleavage of the Cu6Sn5 rods occurred mostly along (0001) or perpendicular to (0001) with some crack deflection between the two. The deterioration of shear impact properties with increasing Cu6Sn5 size is attributed to (1) the larger microcracks introduced by the brittle fracture of larger embedded Cu6Sn5 crystals, and (2) the less numerous and more widely spaced rods when the Cu6Sn5 crystals are larger, which makes them poor strengtheners

GeV detection of HESS J0632+057

HESS J0632+057 is the only gamma-ray binary that has been detected at TeV energies, but not at GeV energies yet. Based on nearly nine years of Fermi Large Area Telescope (LAT) Pass 8 data, we report here on a deep search for the gamma-ray emission from HESS J0632+057 in the 0.1-300 GeV energy range. We find a previously unknown gamma-ray source, Fermi J0632.6+0548, spatially coincident with HESS J0632+057. The measured flux of Fermi J0632.6+0548 is consistent with the previous flux upper limit on HESS J0632+057 and shows variability that can be related to the HESS J0632+057 orbital phase. We propose that Fermi J0632.6+0548 is the GeV counterpart of HESS J0632+057. Considering the Very High Energy (VHE) spectrum of HESS J0632+057, a possible spectral turnover above 10 GeV may exist in Fermi J0632.6+0548, as appears to be common in other established gamma-ray binaries.Comment: 17 pages, 4 figures, 1 table; Accepted for publication in Ap

A Dielectric Affinity Microbiosensor

We present an affinity biosensing approach that exploits changes in dielectric properties of a polymer due to its specific, reversible binding with an analyte. The approach is demonstrated using a microsensor comprising a pair of thin-film capacitive electrodes sandwiching a solution of poly(acrylamide-ran-3-acrylamidophenylboronic acid), a synthetic polymer with specific affinity to glucose. Binding with glucose induces changes in the permittivity of the polymer, which can be measured capacitively for specific glucose detection, as confirmed by experimental results at physiologically relevant concentrations. The dielectric affinity biosensing approach holds the potential for practical applications such as long-term continuous glucose monitoring

Computational investigation of static multipole polarizabilities and sum rules for ground-state hydrogen-like ions

High precision multipole polarizabilities, $\alpha_{\ell}$ for $\ell \le 4$ of the $1s$ ground state of the hydrogen isoelectronic series are obtained from the Dirac equation using the B-spline method with Notre Dame boundary conditions. Compact analytic expressions for the polarizabilities as a function of $Z$ with a relative accuracy of 10$^{-6}$ up to $Z = 100$ are determined by fitting to the calculated polarizabilities. The oscillator strengths satisfy the sum rules $\sum_i f^{(\ell)}_{0i} = 0$ for all multipoles from $\ell = 1$ to $\ell = 4$. The dispersion coefficients for the long-range H-H and H-He$^+$ interactions are given.Comment: 8 figures, 8 table

Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer.

BackgroundWe previously developed a bladder cancer-specific ligand (PLZ4) that can specifically bind to both human and dog bladder cancer cells in vitro and in vivo. We have also developed a micelle nanocarrier drug-delivery system. Here, we assessed whether the targeting micelles decorated with PLZ4 on the surface could specifically target dog bladder cancer cells.Materials and methodsMicelle-building monomers (ie, telodendrimers) were synthesized through conjugation of polyethylene glycol with a cholic acid cluster at one end and PLZ4 at the other, which then self-assembled in an aqueous solution to form micelles. Dog bladder cancer cell lines were used for in vitro and in vivo drug delivery studies.ResultsCompared to nontargeting micelles, targeting PLZ4 micelles (23.2 ± 8.1 nm in diameter) loaded with the imaging agent DiD and the chemotherapeutic drug paclitaxel or daunorubicin were more efficient in targeted drug delivery and more effective in cell killing in vitro. PLZ4 facilitated the uptake of micelles together with the cargo load into the target cells. We also developed an orthotopic invasive dog bladder cancer xenograft model in mice. In vivo studies with this model showed the targeting micelles were more efficient in targeted drug delivery than the free dye (14.3×; P < 0.01) and nontargeting micelles (1.5×; P < 0.05).ConclusionTargeting micelles decorated with PLZ4 can selectively target dog bladder cancer cells and potentially be developed as imaging and therapeutic agents in a clinical setting. Preclinical studies of targeting micelles can be performed in dogs with spontaneous bladder cancer before proceeding with studies using human patients

On Estimation of Fully Entangled Fraction

We study the fully entangled fraction (FEF) of arbitrary mixed states. New upper bounds of FEF are derived. These upper bounds make complements on the estimation of the value of FEF. For weakly mixed quantum states, an upper bound is shown to be very tight to the exact value of FEF.Comment: 8 pages, 2 figure

Symmetries and Lie algebra of the differential-difference Kadomstev-Petviashvili hierarchy

By introducing suitable non-isospectral flows we construct two sets of symmetries for the isospectral differential-difference Kadomstev-Petviashvili hierarchy. The symmetries form an infinite dimensional Lie algebra.Comment: 9 page

Hybrid exciton-polaritons in a bad microcavity containing the organic and inorganic quantum wells

We study the hybrid exciton-polaritons in a bad microcavity containing the organic and inorganic quantum wells. The corresponding polariton states are given. The analytical solution and the numerical result of the stationary spectrum for the cavity field are finishedComment: 3 pages, 1 figure. appear in Communications in Theoretical Physic

Revisiting Galaxy Evolution in Morphology in the COSMOS field (COSMOS-ReGEM):I. Merging Galaxies

We revisit the evolution of galaxy morphology in the COSMOS field over the redshift range $0.2\leq z \leq 1$, using a large and complete sample of 33,605 galaxies with a stellar mass of log($M_{\ast}$/M$_{\odot} )>9.5$ with significantly improved redshifts and comprehensive non-parametric morphological parameters. Our sample has 13,881 ($\sim41.3\%$) galaxies with reliable spectroscopic redshifts and has more accurate photometric redshifts with a $\sigma_{\rm NMAD} \sim 0.005$. This paper is the first in a series that investigates merging galaxies and their properties. We identify 3,594 major merging galaxies through visual inspection and find 1,737 massive galaxy pairs with log($M_\ast$/M$_\odot$)$>10.1$. Among the family of non-parametric morphological parameters including $C$, $A$, $S$, $Gini$, $M_{\rm 20}$, $A_{\rm O}$, and $D_{\rm O}$, we find that the outer asymmetry parameter $A_{\rm O}$ and the second-order momentum parameter $M_{\rm 20}$ are the best tracers of merging features than other combinations. Hence, we propose a criterion for selecting candidates of violently star-forming mergers: $M_{\rm 20}> -3A_{\rm O}+3$ at $0.2 -6A_{\rm O}+3.7$ at $0.6<z<1.0$. Furthermore, we show that both the visual merger sample and the pair sample exhibit a similar evolution in the merger rate at $z<1$, with $\Re \sim(1+z)^{1.79 \pm 0.13}$ for the visual merger sample and $\Re \sim(1+z)^{2.02\pm 0.42}$ for the pair sample. The visual merger sample has a specific star formation rate that is about 0.16\,dex higher than that of non-merger galaxies, whereas no significant star formation excess is observed in the pair sample. This suggests that the effects of mergers on star formation differ at different merger stages.Comment: 21 pages, 12 figures; accepted for publication in Ap

Destruction of LED heterostructures under high-current electron beam irradiation

This paper presents the experimental results of the fracture morphology of InGaN/GaN heterostructures and epitaxial GaN layers deposited on sapphire substrates after irradiation with high current electron beams. A special type of damage - microspheres, ~1-5 [mu]m was discovered and studied. The results show that the microspheres act as diffractive optical elements redistributing the stimulated emission of InGaN/GaN in space