180 research outputs found
Putting theory into practice - a case study in one U.K. Medical school of the nature and extent of unprofessional behaviour over a 6-year period
Producing a medical profession which is fit for the demands and expectations of society involves ensuring that practitioners learn what it means to behave in a 'professional' way. Codes of professional conduct have been developed for medical students in the UK, but the literature on how medical schools actually apply these is small. More detail is needed to evaluate approaches to assessing professionalism, or to analyse the extent to which students 'fail' this aspect
Towards a Java Subtyping Operad
The subtyping relation in Java exhibits self-similarity. The self-similarity
in Java subtyping is interesting and intricate due to the existence of wildcard
types and, accordingly, the existence of three subtyping rules for generic
types: covariant subtyping, contravariant subtyping and invariant subtyping.
Supporting bounded type variables also adds to the complexity of the subtyping
relation in Java and in other generic nominally-typed OO languages such as C#
and Scala. In this paper we explore defining an operad to model the
construction of the subtyping relation in Java and in similar generic
nominally-typed OO programming languages. Operads, from category theory, are
frequently used to model self-similar phenomena. The Java subtyping operad, we
hope, will shed more light on understanding the type systems of generic
nominally-typed OO languages.Comment: 13 page
On the asymptotic magnitude of subsets of Euclidean space
Magnitude is a canonical invariant of finite metric spaces which has its
origins in category theory; it is analogous to cardinality of finite sets.
Here, by approximating certain compact subsets of Euclidean space with finite
subsets, the magnitudes of line segments, circles and Cantor sets are defined
and calculated. It is observed that asymptotically these satisfy the
inclusion-exclusion principle, relating them to intrinsic volumes of polyconvex
sets.Comment: 23 pages. Version 2: updated to reflect more recent work, in
particular, the approximation method is now known to calculate (rather than
merely define) the magnitude; also minor alterations such as references adde
Wheeled PROPs, graph complexes and the master equation
We introduce and study wheeled PROPs, an extension of the theory of PROPs
which can treat traces and, in particular, solutions to the master equations
which involve divergence operators. We construct a dg free wheeled PROP whose
representations are in one-to-one correspondence with formal germs of
SP-manifolds, key geometric objects in the theory of Batalin-Vilkovisky
quantization. We also construct minimal wheeled resolutions of classical
operads Com and Ass as rather non-obvious extensions of Com_infty and
Ass_infty, involving, e.g., a mysterious mixture of associahedra with
cyclohedra. Finally, we apply the above results to a computation of cohomology
of a directed version of Kontsevich's complex of ribbon graphs.Comment: LaTeX2e, 63 pages; Theorem 4.2.5 on bar-cobar construction is
strengthene
The peritoneal tumour microenvironment of high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSC) disseminates early and extensively throughout the peritoneal space, causing multiple lesions that are a major clinical problem. The aim of this study was to investigate the cellular composition of peritoneal tumour deposits in patient biopsies and their evolution in mouse models using immunohistochemistry, intravital microscopy, confocal microscopy, and 3D modelling. Tumour deposits from the omentum of HGSC patients contained a prominent leukocyte infiltrate of CD3(+) T cells and CD68(+) macrophages, with occasional neutrophils. Alpha-smooth muscle actin(+) (α-SMA(+) ) pericytes and/or fibroblasts surrounded these well-vascularized tumour deposits. Using the murine bowel mesentery as an accessible mouse peritoneal tissue that could be easily imaged, and two different transplantable models, we found multiple microscopic tumour deposits after i.p. injection of malignant cells. Attachment to the peritoneal surface was rapid (6-48 h) with an extensive CD45(+) leukocyte infiltrate visible by 48 h. This infiltrate persisted until end point and in the syngeneic murine ID8 model, it primarily consisted of CD3(+) T lymphocytes and CD68(+) macrophages with α-SMA(+) cells also involved from the earliest stages. A majority of tumour deposits developed above existing mesenteric blood vessels, but in avascular spaces new blood vessels tracked towards the tumour deposits by 2-3 weeks in the IGROV-1 xenografts and 6 weeks in the ID8 syngeneic model; a vigorous convoluted blood supply was established by end point. Inhibition of tumour cell cytokine production by stable expression of shRNA to CXCR4 in IGROV-1 cells did not influence the attachment of cells to the mesentery but delayed neovascularization and reduced tumour deposit size. We conclude that the multiple peritoneal tumour deposits found in HGSC patients can be modelled in the mouse. The techniques described here may be useful for assessing treatments that target the disseminated stage of this disease
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