Effect of the acrylic acid content on the permeability and water uptake of latex films

Acrylic acid (AA) is a monomer commonly employed in emulsion polymerization to provide electrostatic colloidal stability and improve specific film performance. The addition of AA not only modifies the kinetics of the polymerization, but also it takes part in the interaction between colloidal particles, which has a strong influence on their packing and consequent latex film properties. In this contribution a theoretical modeling of the latex film formation is presented and compared to experimental results: water vapor permeability and latex film capacitance are studied as a function of AA content. It has been shown that water uptake is mainly affected by film morphology which in turn is defined by intercolloidal interaction and drying rate.Comment: 16 pages, 7 figure

Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence

A Corrigendum to this article was published on 14 August 2014 6 DOI / 10.1038/cddis.2014.360Since the publication of this paper the authors have noticed an error in the abstract section. ‘Inversely, expressing a G6P,pharmacological inhibition of HK2,’ is replaced by ‘Inversely, expressing a glucose-6-phosphatase, pharmacological inhibition of HK2,’.The corrected article appears online together with this corrigendum.The authors would like to apologize for any inconvenience caused.International audienceOncogenic stress-induced senescence (OIS) prevents the ability of oncogenic signals to induce tumorigenesis. It is now largely admitted that the mitogenic effect of oncogenes requires metabolic adaptations to respond to new energetic and bio constituent needs. Yet, whether glucose metabolism affects OIS response is largely unknown. This is largely because of the fact that most of the OIS cellular models are cultivated in glucose excess. In this study, we used human epithelial cells, cultivated without glucose excess, to study alteration and functional role of glucose metabolism during OIS. We report a slowdown of glucose uptake and metabolism during OIS. Increasing glucose metabolism by expressing hexokinase2 (HK2), which converts glucose to glucose-6phosphate (G6P), favors escape from OIS. Inversely, expressing a glucose-6-phosphatase, pharmacological inhibition of HK2, or adding nonmetabolizable glucose induced a premature senescence. Manipulations of various metabolites covering G6P downstream pathways (hexosamine, glycolysis, and pentose phosphate pathways) suggest an unexpected role of the hexosamine pathway in controlling OIS. Altogether, our results show that decreased glucose metabolism occurs during and participates to OIS

DEDICAT 6G - Dynamic coverage extension and distributed intelligence for human centric applications with assured security, privacy and trust:From 5G to 6G

5G networks offer unparalleled data rates and features. However these are still far from what a hyperconnected society and industry needs. Future wireless connectivity Beyond 5G (B5G)/6G will require a smart and green platform that is ultra-fast, highly adaptive, and dependable to support innovative, human-centric applications securely. This is the focus of the EU-funded DEDICAT 6G project, the vision and methodology of which is presented in this paper. DEDICAT 6G investigates enablers for dynamic distribution of intelligence to improve task execution time, energy efficiency, and ultimately, reduce end-to-end latency. The project also examines solutions for dynamic coverage extensions utilizing robots, connected vehicles and drones. The scope also comprises methods for security, privacy, and trust assurance including enablers for novel interaction between humans and digital systems exploiting innovative interfaces and devices, like smart glasses. DEDICAT 6G focuses on four representative 6G use cases: Smart Warehousing, Enhanced Experience, Public Safety and Smart Highway. The developed solutions will be demonstrated and tested in these use cases through experiments in laboratory environments, and larger field evaluations utilizing diverse assets and testing facilities. The aim is to derive results that will showcase substantial improvements in terms of intelligent network load balancing and resource allocation, extended coverage, enhanced security, privacy and trust and human-machine applications, </p