Subduction-zone structure and magmatic processes beneath Costa Rica constrained by local earthquake tomography and petrological modelling

A high-quality data set of 3790 earthquakes were simultaneously inverted for hypocentre locations and 3-D P-wave velocities in Costa Rica. Tests with synthetic data and resolution estimates derived from the resolution matrix indicate that the velocity model is well constrained in central Costa Rica to a depth of 70 km; northwestern and southeastern Costa Rica are less well resolved owing to a lack of seismic stations and seismicity. Maximum H2O content and seismic wave speeds of mid-ocean ridge basalt and harzburgite were calculated for metamorphic phase transformations relevant to subduction. Both the 3-D P-wave velocity structure and petrological modelling indicate the existence of low-velocity hydrous oceanic crust in the subducting Cocos Plate beneath central Costa Rica. Intermediate-depth seismicity correlates well with the predicted locations of hydrous metamorphic rocks, suggesting that dehydration plays a key role in generating intermediate-depth earthquakes beneath Costa Rica. Wadati-Benioff zone seismicity beneath central Costa Rica shows a remarkable decrease in maximum depth toward southeastern Costa Rica. The presence of asthenosphere beneath southeastern Costa Rica, which entered through a proposed slab window, may explain the shallowing of seismicity due to increased temperatures and associated shallowing of dehydration of the slab. Tomographic images further constrain the existence of deeply subducted seamounts beneath central Costa Rica. Large, low P-wave velocity areas within the lower crust are imaged beneath the southeasternmost volcanoes in central Costa Rica. These low velocities may represent anomalously hot material or even melt associated with active volcanism in central Costa Rica. Tomographic images and petrological modelling indicate the existence of a shallow, possibly hydrated mantle wedge beneath central Costa Ric

Accurate hypocentre determination in the seismogenic zone of the subducting Nazca Plate in northern Chile using a combined on-/offshore network

The coupled plate interface of subduction zones—commonly called the seismogenic zone—has been recognized as the origin of fatal earthquakes. A subset of the after-shock series of the great Antofagasta thrust-type event (1995 July 30; Mw= 8.0) has been used to study the extent of the seismogenic zone in northern Chile. To achieve reliable and precise hypocentre locations we applied the concept of the minimum 1-D model, which incorporates iterative simultaneous inversion of velocity and hypocentre parameters. The minimum 1-D model is complemented by station corrections which are influenced by near-surface velocity heterogeneity and by the individual station elevations. By relocating mine blasts, which were not included in the inversion, we obtain absolute location errors of 1 km in epicentre and 2 km in focal depth. A study of the resolution parameters ALE and DSPR documents the importance of offshore stations on location accuracy for offshore events. Based on precisely determined hypo-centres we calculate a depth of 46 km for the lower limit of the seismogenic zone, which is in good agreement with previous studies for this area. For the upper limit we found a depth of 20 km. Our results of an aseismic zone between the upper limit of the seismogenic zone and the surface correlates with a detachment zone proposed by other studies; the results are also in agreement with thermal studies for the Antofagasta forearc regio

Consistent phase picking for regional tomography models: application to the greater Alpine region

The resolution and reliability of tomographic velocity models strongly depends on quality and consistency of available traveltime data. Arrival times routinely picked by network analysts on a day-to-day basis often yield a high level of noise due to mispicks and other inconsistencies, particularly in error assessment. Furthermore, tomographic studies at regional scales require merging of phase picks from several networks. Since a common quality assessment is not usually available for phase data provided by different networks, additional inconsistencies are introduced by the merging process. Considerable improvement in the quality of phase data can only be achieved through complete repicking of seismograms. Considering the amount of data necessary for regional high-resolution tomography, algorithms combining accurate picking with an automated error assessment represent the best tool to derive large suitable data sets. In this work, we present procedures for consistent automated and routine picking of P-wave arrival times at local to regional scales including consistent picking error assessment. Quality-attributed automatic picks are derived from the MPX picking system. The application to earthquakes in the greater Alpine region demonstrates the potential of such a repicking approach. The final data set consists of more than 13 000 high-quality first-arrivals and it is used to derive regional 1-D and preliminary 3-D P-wave models of the greater Alpine region. The comparison with a tomographic model based on routine phase data extracted from the ISC Bulletin illustrates effects on tomographic results due to consistency and reliability of our high-quality data se

High-resolution 3-D P-wave model of the Alpine crust

The 3-D P-wave velocity structure of the Alpine crust has been determined from local earthquake tomography using a set of high-quality traveltime data. The application of an algorithm combining accurate phase picking with an automated quality assessment allowed the repicking of first arriving P-phases from the original seismograms. The quality and quantity of the repicked phase data used in this study allows the 3-D imaging of large parts of the Alpine lithosphere between 0 and 60 km depth. Our model represents a major improvement in terms of reliability and resolution compared to any previous regional tomographic studies of the Alpine crust. First-order anomalies like crust—mantle boundary (Moho) and the Ivrea body in the Western Alps are well resolved and in good agreement with previous studies. In addition, several (consistent) small-scale anomalies are visible in the tomographic image. A clear continuation of the lower European crust beneath the Adriatic Moho in the Central Alps is not observed in our results. The absence of such a signature may indicate the eclogitization of the subducted European lower crust in the Central Alps. In agreement with previous results, the additional analysis of focal depths in our new 3-D P-wave model shows that all studied earthquakes in the northern foreland have occurred within the European crust. Waveforms and focal depths suggest that at least one of the analysed events south of the Alps is located in the Adriatic mantl

A Survival-Adjusted Quantal-Response Test for Analysis of Tumor Incidence Rates in Animal Carcinogenicity Studies

In rodent cancer bioassays, groups of animals are exposed to different doses of a chemical of interest and followed for tumor occurrence. The resulting tumor rates are commonly analyzed using a survival-adjusted Cochran-Armitage (CA) trend test. The CA trend test has reasonable power when the tumor-response curve is linear in dose, but it may be underpowered for a nonlinear response. An alternative survival-adjusted test procedure based on isotonic regression methodology has previously been proposed. Although this alternative procedure performs well when the tumor response is nonlinear in dose, it has less power than the CA trend test when the response is linear in dose. Here, we introduce a new survival-adjusted test procedure that makes use of both the CA trend test and the isotonic regression-based trend test. Using a broad range of experimental conditions typical of National Toxicology Program (NTP) bioassays, we conducted extensive computer simulations to compare the false-positive error rate and power of the proposed procedure with the survival-adjusted CA trend test. The new procedure competes well with the survival-adjusted CA trend test when observed tumor rates are linear in dose and performs substantially better when observed tumor rates are nonlinear in dose. Further, the proposed trend test almost always has a smaller false-positive rate than does the survival-adjusted CA trend test. We also developed an order-restricted inference-based procedure for performing multiple pairwise comparisons between each of the dose groups and the control group. The trend test and the multiple pairwise comparisons test are demonstrated using an example from a study conducted by the NTP

Syphilis and parvovirus B19 co-infection imitating a lupus nephropathy: A case report.

Syphilis can share clinical features with autoimmune diseases, such as cutaneous Lupus or rheumatoid arthritis. Moreover, secondary syphilis can have visceral involvement, thus affecting the kidney. Syphilitic nephropathy causes nephrotic syndrome with a classic membranous pattern. We present a unique presentation of a co-infection by syphilis and parvovirus B19 sharing all the biological and histological features of proliferative lupus nephritis (LN). We present a case of a 71-year-old Caucasian male returning from a trip to Asia presenting with nephrotic syndrome with antinuclear antibodies (ANA) positivity. Because of nephrotic syndrome a kidney biopsy was performed. It demonstrated a membranous nephropathy with extracapillary proliferation and a full house pattern (presence of IgA, IgG, IgM and C1Q deposits) on immunofluorescence (IF), highly suggestive of LN class III and V. However, several atypical clinical features notably the age, sex of the patient and the history of travel prompt us to search for another cause of nephropathy. A serology was positive for syphilis and a PCR in the renal biopsy was also positive for parvovirus B19. Thus, a co-infection by syphilis and parvovirus B19 was funded to be the cause of the renal lesions. The proteinuria improved; a course of antibiotic was administrated because of neurologic syphilitic involvement (presence of headache with positive syphilis serology in the CSF). A co-infection by syphilis and parvovirus B19 can share all the biological and histological features of proliferative LN and must be recognized as a cause of pseudo-lupus nephritis

Hemodialysis for cefepime intoxication: A case report

Introduction: We report a case of cefepime intoxication with acute severe neurologic symptoms, which was treated by temporary hemodialysis. Patients (or Materials) and Methods: Cefepime 2 g BID for endovascular prosthesis infection was prescribed to a frail, chronically ill 88-year-old woman with a serum creatinine of 199 μmol/L and an estimated creatinine clearance of 13 mL/min (Cockroft formula). Two days later, she was transferred to a neurocritical care unit because of acute aphasia, myoclonic jerks, and delirium with a Glasgow coma scale score of 12/15. The following day, in the absence of other causes, cefepime intoxication was hypothesized, and cefepime was withdrawn after a total of 7 doses = 14 g. Over the next 24 hours, two 3-hour hemodialysis (HD) sessions were performed under cefepime concentration monitoring. Results: Cefepime plasma levels were measured by liquid chromatography/ mass spectrometry. There is no validated reference range, but a study (Chapuis T et al, Critical Care, 2010) found a 50% risk of neurotoxicity with residual levels > 15 mg/L. In our patient, levels were 83.3 mg/L 10 hours after last dose, 24.1 mg/L immediately after the first HD session, 13.4 mg/L immediately before the second HD session, and 2.5 mg/L immediately after the second HD session. The patient made a full clinical recovery over the next 48 hours. The 70% to 80% fall in plasmatic levels observed during each HD session is in accordance with literature data (Schmaldienst S et al, Eur J Clin Pharmacol, 2000, and Manyor LM et al, Pharmacotherapy, 2008). According to kinetic simulation, cefepime dropped at a concentration < 15 mg/L 15 hours earlier with HD than it would have without. Conclusion: Neuropsychiatric adverse effects of beta-lactam antibiotics can be easily overlooked by clinicians. One should be especially cautious with their use in very old and frail patients in whom plasma creatinine poorly estimates renal function and cognitive impairment is highly prevalent. Temporary hemodialysis effectively clears cefepime, but its role in hastening clinical recovery may be limited

A new absolute arrival time data set for Europe

The main aim of this study is to create a data set of accurate absolute arrival times for stations in Europe which do not report to the International Seismological Centre (ISC). Waveforms were obtained from data centres and temporary experiments and a semi-automatic picking method was applied to determine absolute arrival times for P and S phases. 85 000 arrival times were picked whose distribution of residuals shows generally low standard deviations on the order of 0.5-0.7 s. Furthermore, mean teleseismic station residuals reflect the properties of the underlying crust and uppermost mantle. Comparison to ISC data for matching event-station-phase combinations also confirms the good quality of the new absolute arrival time picks. Most importantly, this data set complements the ISC data as it fills regional data coverage gaps in Europ