782 research outputs found
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The synovial cadherin (cadherin-11) promotes intercellular motility
Fast-neutron induced background in LaBr3:Ce detectors
The response of a scintillation detector with a cylindrical 1.5-inch LaBr3:Ce
crystal to incident neutrons has been measured in the energy range En = 2-12
MeV. Neutrons were produced by proton irradiation of a Li target at Ep = 5-14.6
MeV with pulsed proton beams. Using the time-of-flight information between
target and detector, energy spectra of the LaBr3:Ce detector resulting from
fast neutron interactions have been obtained at 4 different neutron energies.
Neutron-induced gamma rays emitted by the LaBr3:Ce crystal were also measured
in a nearby Ge detector at the lowest proton beam energy. In addition, we
obtained data for neutron irradiation of a large-volume high-purity Ge detector
and of a NE-213 liquid scintillator detector, both serving as monitor detectors
in the experiment. Monte-Carlo type simulations for neutron interactions in the
liquid scintillator, the Ge and LaBr3:Ce crystals have been performed and
compared with measured data. Good agreement being obtained with the data, we
present the results of simulations to predict the response of LaBr3:Ce
detectors for a range of crystal sizes to neutron irradiation in the energy
range En = 0.5-10 MeVComment: 28 pages, 10 figures, 4 Table
New determinations of gamma-ray line intensities of the Ep = 550 keV and Ep = 1747 keV resonances of the 13-C(p,gamma)14-N reaction
Gamma-ray angular distributions for the resonances at Ep = 550 keV and 1747
keV of the radiative capture reaction 13-C(p,g)14-N have been measured, using
intense proton beams on isotopically pure 13-C targets. Relative intensities
for the strongest transitions were extracted with an accuracy of typically five
per cent, making these resonances new useful gamma-ray standards for efficiency
calibration in the energy range Egamma = 1.6 to 9 MeV.Comment: 17 pages, 6 figures, Nuclear Instruments and Methods, Sec. A,
accepte
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Influence of annealing on microstructure and mechanical properties of ultrafine-grained Ti45Nb
Beta-Ti alloys have been intensively investigated in the last years because of their favorable low Young's moduli, biocompatibility and bio-inertness, making these alloys interesting candidates for implant materials. Due to their low mechanical strength, efforts are currently devoted to increasing it. A promising way to improve the strength is to tailor the microstructure using severe plastic deformation (SPD). In this investigation high pressure torsion was used to refine the microstructure of a Ti-45wt.%Nb alloy inducing a grain size of ~50 nm. The main focus of the subsequent investigations was devoted to the thermal stability of the microstructure. Isochronal heat-treatments performed for 30 min in a temperature range up to 500 °C caused an increase of hardness with a peak value at 300 °C before the hardness decreased at higher temperatures. Simultaneously, a distinct temperature-dependent variation of the Young's modulus was also measured. Tensile tests revealed an increase in strength after annealing compared to the SPD-state. Microstructural investigations showed that annealing causes the formation of α-Ti. The findings suggest that the combination of severe plastic deformation with subsequent heat treatment provides a feasible way to improve the mechanical properties of SPD-deformed β-Ti alloys making them suitable for higher strength applications
Motavizumab, A Neutralizing Anti-Respiratory Syncytial Virus (Rsv) Monoclonal Antibody Significantly Modifies The Local And Systemic Cytokine Responses Induced By Rsv In The Mouse Model
Motavizumab (MEDI-524) is a monoclonal antibody with enhanced neutralizing activity against RSV. In mice, motavizumab suppressed RSV replication which resulted in significant reduction of clinical parameters of disease severity. We evaluated the effect of motavizumab on the local and systemic immune response induced by RSV in the mouse model. Balb/c mice were intranasally inoculated with 106.5 PFU RSV A2 or medium. Motavizumab was given once intraperitoneally (1.25 mg/mouse) as prophylaxis, 24 h before virus inoculation. Bronchoalveolar lavage (BAL) and serum samples were obtained at days 1, 5 (acute) and 28 (long-term) post inoculation and analyzed with a multiplex assay (Beadlyte Upstate, NY) for simultaneous quantitation of 18 cytokines: IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, KC (similar to human IL-8), IL-10, IL-12p40, IL-12p70, IL-13, IL-17, TNF-α, MCP-1, RANTES, IFN-γ and GM-CSF. Overall, cytokine concentrations were lower in serum than in BAL samples. By day 28, only KC was detected in BAL specimens at low concentrations in all groups. Administration of motavizumab significantly reduced (p < 0.05) BAL concentrations of IL-1α, IL-12p70 and TNF-α on day 1, and concentrations of IFN-γ on days 1 and 5 compared with RSV-infected untreated controls. In the systemic compartment, the concentrations of IL-10, IFN-γ and KC were significantly reduced in the motavizumab-treated mice compared with the untreated controls. In summary, prophylactic administration of motavizumab was associated with significant reductions on RSV replication and concentrations of cytokine and chemokines, which are likely related to the improvement observed in clinical markers of disease severity
A new experiment for the determination of the 18F(p,alpha) reaction rate at nova temperatures
The 18F(p,alpha) reaction was recognized as one of the most important for
gamma ray astronomy in novae as it governs the early 511 keV emission. However,
its rate remains largely uncertain at nova temperatures. A direct measurement
of the cross section over the full range of nova energies is impossible because
of its vanishing value at low energy and of the short 18F lifetime. Therefore,
in order to better constrain this reaction rate, we have performed an indirect
experiment taking advantage of the availability of a high purity and intense
radioactive 18F beam at the Louvain La Neuve RIB facility. We present here the
first results of the data analysis and discuss the consequences.Comment: Contribution to the Classical Novae Explosions conference, Sitges,
Spain, 20-24 May 2002, 5 pages, 3 figure
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