Epidemiology and clinical features of inflammatory retinal vascular occlusions : pooled data from two tertiary-referral institutions

Importance: In a subset of patients with retinal vasculitis, there is occlusion of blood flow through the retinal vessels. These eyes are at high risk of sight-threatening complications. Background: To characterize epidemiology, clinical course, treatment and outcomes of occlusive retinal vasculitis (ORV). Design: Retrospective study Participants: Seventy-seven uveitis patients with ORV at two large tertiary-care institutions (the USA and India). Methods: Out of 2438 patients screened, 346 patients were diagnosed with retinal vasculitis of which 77 patients (96 eyes) were diagnosed with ORV. Patients with ORV (capillary, arteriolar and/or venular) were further analysed. Diagnostic criteria for occlusive vasculitis included (i) absence of blood flow in vessels (arterioles, venules and/or capillaries), (ii) capillary non-perfusion areas and/or arteriolar-venous anastomosis and (iii) intraretinal haemorrhages, cotton-wool spots or vitreous haemorrhage. Main Outcome Measures: Best-corrected visual acuity, treatment and complications. Results: The mean age was 32.09 \ub1 13.51 years. Most common aetiologies were tuberculosis and Adamantiades-Beh\ue7et's disease in India and systemic lupus erythematosus in the USA. Best-corrected visual acuity improved from 0.38 \ub1 0.30 logMAR (20/48 Snellen equivalent) (baseline) to 0.25 \ub1 0.30 (20/35 Snellen equivalent) at final visit (P < 0.0001). Vitreous haemorrhage was seen in 31.08% eyes. Pars plana vitrectomy was performed in 12.16% eyes. Therapy with systemic steroids was required in 78.48% patients. In addition, 46.75% patients required immunomodulators and/or biologics. Conclusions: Occlusive retinal vasculitis is caused by heterogeneous group of uveitides depending upon the geographic location. It is imperative to identify eyes with ORV as they are predisposed to complications requiring aggressive therapy

Interleukin-6 inhibition in the management of non-infectious uveitis and beyond

Uveitis consists of a spectrum of inflammatory disorders characterized by ocular inflammation. The underlying pathophysiology consists of a complex interplay of various inflammatory pathways. Interleukin 6 is an important mediator of inflammation in uveitis and constitutes focus of research toward development of newer biological therapies in the management of non-infectious uveitis