The Power of the Test for the Winsorized Modified Alexander-Govern Test

This research examined the USAge of the parametric method in comparing two or more means as independent group test, for instance, the Alexander-Govern (AG) test. The utilization of mean as the determinant for the center of distribution of variance diversity takes place in testing, and the test provides excellence in maintaining the amount of Type I error and giving immense sensitivity for a regular data. Unfortunately, it isineffective on irregular data, leading to the application of trimmed mean upon testing as the determinant for the center of distribution under irregular data for two group condition. However, as the group quantity is more than two, the estimator unsuccessfully provides excellence in maintaining the amount of Type I error. Therefore, an estimator high in effectiveness called the MOM estimator was introduced for the testing as the determinant for the center of distribution. Group quantity in a test does not affect the estimator, but it unsuccessfully providesexcellence in maintaining the amount of Type I error under intense asymmetry and unevenness. The application of Winsorized modified one-step M-estimator (WMOM) upon the Alexander-Govern testing takes place so that it can prevail against its drawbacks under irregular data in the presence of variance diversity, can eliminate the presence of the outside observation and can provide effectiveness for the testing on irregular data. Statistical Analysis Software (SAS) was used for the analysis of the tests. The results show that the AGWMOM test gave the most intense sensitivity under g = 0,5 and h = 0,5, for four group case and g = 0 and h = 0, under six group case, differing from three remaining tests and the sensitivity of the AG testing is said suffices and intense enough

Evaluation of BIM Education for Quantity Surveying: A Review of Teaching Approaches

Building Information Modelling (BIM) technology has become increasingly well-known among construction industry players throughout the world. It is known as a process that offers numerous benefits by the implementation in the industry. Almost 50% of practitioners in construction industry is using BIM. Quantity Surveyors (QS) are one of the important main professionals in construction industry who should have an adequate and sufficient BIM knowledge and skills. Equivalent to this, based on the educational perspective it is clear that there is a growing need for universities to provide their graduates with appropriate BIM-related skills. Although the educational frameworks that have been established for academic purposes in Malaysia, still, it is in doubt whether this framework is parallel with industry’s demand and also whether the knowledge and skills provided sufficient with industry’s requirements. It is crucial to recognize the applicable teaching approach for BIM educations in order to ensure students capable in applying BIM tools and meet the expectation of industry. This paper reviews the BIM teaching approaches and the BIM module applied in QS undergraduate program.   Keywords: BIM, quantity surveyors, QS education, teaching approach, Malaysi

DNA Methylation Changes in Atypical Adenomatous Hyperplasia, Adenocarcinoma In Situ, and Lung Adenocarcinoma

BACKGROUND:Aberrant DNA methylation is common in lung adenocarcinoma, but its timing in the phases of tumor development is largely unknown. Delineating when abnormal DNA methylation arises may provide insight into the natural history of lung adenocarcinoma and the role that DNA methylation alterations play in tumor formation. METHODOLOGY/PRINCIPAL FINDINGS:We used MethyLight, a sensitive real-time PCR-based quantitative method, to analyze DNA methylation levels at 15 CpG islands that are frequently methylated in lung adenocarcinoma and that we had flagged as potential markers for non-invasive detection. We also used two repeat probes as indicators of global DNA hypomethylation. We examined DNA methylation in 249 tissue samples from 93 subjects, spanning the putative spectrum of peripheral lung adenocarcinoma development: histologically normal adjacent non-tumor lung, atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS, formerly known as bronchioloalveolar carcinoma), and invasive lung adenocarcinoma. Comparison of DNA methylation levels between the lesion types suggests that DNA hypermethylation of distinct loci occurs at different time points during the development of lung adenocarcinoma. DNA methylation at CDKN2A ex2 and PTPRN2 is already significantly elevated in AAH, while CpG islands at 2C35, EYA4, HOXA1, HOXA11, NEUROD1, NEUROD2 and TMEFF2 are significantly hypermethylated in AIS. In contrast, hypermethylation at CDH13, CDX2, OPCML, RASSF1, SFRP1 and TWIST1 and global DNA hypomethylation appear to be present predominantly in invasive cancer. CONCLUSIONS/SIGNIFICANCE:The gradual increase in DNA methylation seen for numerous loci in progressively more transformed lesions supports the model in which AAH and AIS are sequential stages in the development of lung adenocarcinoma. The demarcation of DNA methylation changes characteristic for AAH, AIS and adenocarcinoma begins to lay out a possible roadmap for aberrant DNA methylation events in tumor development. In addition, it identifies which DNA methylation changes might be used as molecular markers for the detection of preinvasive lesions