Nonuniqueness in a minimal model for cell motility

Two–phase flow models have been used previously to model cell motility, however these have rapidly become very complicated, including many physical processes, and are opaque. Here we demonstrate that even the simplest one–dimensional, two–phase, poroviscous, reactive flow model displays a number of behaviours relevant to cell crawling. We present stability analyses that show that an asymmetric perturbation is required to cause a spatially uniform, stationary strip of cytoplasm to move, which is relevant to cell polarization. Our numerical simulations identify qualitatively distinct families of travelling–wave solution that co–exist at certain parameter values. Within each family, the crawling speed of the strip has a bell–shaped dependence on the adhesion strength. The model captures the experimentally observed behaviour that cells crawl quickest at intermediate adhesion strengths, when the substrate is neither too sticky nor too slippy

Cooperating Agents for 3D Scientific Data Interpretation

Many organizations collect vast quantities of three-dimensional (3-D) scientific data in volumetric form for a range of purposes, including resource exploration, market forecasting, and process modelling. Traditionally, these data have been interpreted by human experts with only minimal software assistance. However, such manual interpretation is a painstakingly slow and tedious process. Moreover, since interpretation involves subjective judgements and each interpreter has different scientific knowledge and experience, formulation of an effective interpretation often requires the cooperation of numerous such experts. Hence, there is a pressing need for a software system in which individual interpretations can be generated automatically and then refined through the use of cooperative reasoning and information sharing. To this end, a prototype system, SurfaceMapper, has been developed in which a community of cooperating software agents automatically locate and display interpretations in a volume of 3-D scientific data. The challenges and experiences in designing and building such a system are discussed. Particular emphasis is given to the agents' interactions and an empirical evaluation of the effectiveness of different cooperation strategies is presented

Strongly Non-Equilibrium Bose-Einstein Condensation in a Trapped Gas

We present a qualitative (and quantitative, at the level of estimates) analysis of the ordering kinetics in a strongly non-equilibrium state of a weakly interacting Bose gas, trapped with an external potential. At certain conditions, the ordering process is predicted to be even more rich than in the homogeneous case. Like in the homogeneous case, the most characteristic feature of the full-scale non-equilibrium process is the formation of superfluid turbulence.Comment: 4 pages, revtex, no figures. Submitted to PR

A Flaring Megamaser in Mrk 348

We report new observations of the H2O megamaser in the Seyfert 2 galaxy Mrk 348. Following our initial detection in 2000 March using the Effelsberg 100 m telescope, re-analysis of previous data on this source indicates that the maser was present but only marginally detectable in late 1997. Monitoring through late 2000 shows that the maser has again decreased to its original level. The H2O line is redshifted by ~130 km/s with respect to the systemic velocity, is extremely broad, with a FWHM of 130 km/s, and has no detectable high velocity components within 1500 km/s on either side of the strong line. Followup VLBA observations show that the maser emission emanates entirely from a region >0.25 pc in extent, toward the base of the radio jet.Comment: 4 pages, 2 figures, to appear in Cosmic Masers: from Protostars to Black Holes, IAU 206, Eds. V. Migenes et al., ASP Conference Serie

Design of Revising Proximity between Space and Time Cues on Flight Deck Displays to Support NextGen – The Second Phase

The prior first phase of this study investigated the effectiveness of new design of flight deck display for required time of arrival operation of NextGen by collecting objective query response data during autopilot flights and subjective data about the perception between display condition and situation awareness level. To evaluate pilots’ mental workload during the operations when they interacted with novel flight deck display design, this second phase provided pilots with simulation flight tasks arriving at four successive waypoints on time in the same display conditions as the first phase and asked them to rate their mental workload ratings. The workload was significantly lower with the High Proximity condition - all space and time data were integrated into a single display and temporal conformance graphics were added removing the need of control display unit - than with the traditional display condition. This result strengthened the implications from the first phase: the close spatial proximity between space and time cues and the support of graphical temporal conformance indicator showed a promise for improved required time of arrival navigation

Design of Revising Proximity between Space and Time Cues on Flight Deck Displays to Support NextGen – The First Phase

The objective of this study is to develop and evaluate novel display formats to support RTA operations for near to midterm NextGen. Traditional cockpit displays separate space and time information in distant display sources in heterogeneous formats (graphics vs. text). This design composition may cause potential pilot errors when required time of arrival (RTA) obligations are imposed at every waypoint in NextGen. Pilots were randomly assigned to four different display conditions in a simulator – one traditional display with distant space and time cues, and three novel displays with close spatial proximity between the two cues. In the first phase of the experiment for this paper, pilots firstly participated in query tests answering space/time statuses during autopilot RTA flights. The novel displays did not degrade pilots’ situation awareness of space-time as an objective measure. For subjective measure, their situation awareness was significantly higher when the space and time cues were integrated into a single display with graphical temporal conformance indicators. The close spatial proximity between space and time cues and the support of graphical temporal conformance indicator showed a promise for improved RTA navigation

The Antiferromagnetic Band Structure of La2CuO4 Revisited

Using the Becke-3-LYP functional, we have performed band structure calculations on the high temperature superconductor parent compound, La2CuO4. Under the restricted spin formalism (rho(alpha) equal to rho(beta)), the R-B3LYP band structure agrees well with the standard LDA band structure. It is metallic with a single Cu x2-y2/O p(sigma) band crossing the Fermi level. Under the unrestricted spin formalism (rho(alpha) not equal to rho(beta)), the UB3LYP band structure has a spin polarized antiferromagnetic solution with a band gap of 2.0 eV, agreeing well with experiment. This state is 1.0 eV (per formula unit) lower than that calculated from the R-B3LYP. The apparent high energy of the spin restricted state is attributed to an overestimate of on-site Coulomb repulsion which is corrected in the unrestricted spin calculations. The stabilization of the total energy with spin polarization arises primarily from the stabilization of the x2-y2 band, such that the character of the eigenstates at the top of the valence band in the antiferromagnetic state becomes a strong mixture of Cu x2-y2/O p(sigma) and Cu z2/O' p(z). Since the Hohenberg-Kohn theorem requires the spin restricted and spin unrestricted calculations give exactly the same ground state energy and total density for the exact functionals, this large disparity in energy reflects the inadequacy of current functionals for describing the cuprates. This calls into question the use of band structures based on current restricted spin density functionals (including LDA) as a basis for single band theories of superconductivity in these materials.Comment: 13 pages, 8 figures, to appear in Phys. Rev. B, for more information see http://www.firstprinciples.co