Impact of social media on e-tourism : a critical analysis of determinants of decision making / V. Sivakumar.

E-Tourism is an emerging trend among the other e-commerce market. Availability of online tourism services has transformed the traditional approach of people in planning their tours and it engage nearly three-fourth of e-commerce share in India. Social media has boomed as the new mode to connect people thus leveraging the impact of social media platform to promote tourism products has established to be an excellent strategy. Social networking sites such as blogs, micro blogs, consumer review sites, content community sites with maximum number of hits, wikis, internet forums and location based social media enable the users to communicate in a way to achieve information search, decision-making and also used by the service providers to achieve promoting tourism services. Exploratory research on the impact of social media in tourism is still in infancy. This paper reports on an online research to establish the various determinants of decision making on using social media for availing tourism services. Research tool is developed based on the extensive review of literature and an online survey is made among the users of relevant social media sites. The data is collected and quantitatively analysed to derive significant factors affecting the decision making of tourists. The authors would also like to acknowledge the funding under RUSA 2.0 Scheme of MHRD, Govt of India

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

MDM2–MDMX complexes bind the p53 tumor-suppressor protein, inhibiting p53's transcriptional activity and targeting p53 for proteasomal degradation. Inhibitors that disrupt binding between p53 and MDM2 efficiently activate a p53 response, but their use in the treatment of cancers that retain wild-type p53 may be limited by on-target toxicities due to p53 activation in normal tissue. Guided by a novel crystal structure of the MDM2–MDMX–E2(UbcH5B)–ubiquitin complex, we designed MDM2 mutants that prevent E2–ubiquitin binding without altering the RING-domain structure. These mutants lack MDM2's E3 activity but retain the ability to limit p53′s transcriptional activity and allow cell proliferation. Cells expressing these mutants respond more quickly to cellular stress than cells expressing wild-type MDM2, but basal p53 control is maintained. Targeting the MDM2 E3-ligase activity could therefore widen the therapeutic window of p53 activation in tumors

A preliminary review of the cultural heritage and emerging pilgrimage tourism in Tamil Nadu / V. Sivakumar ... [et al.]

Pilgrimage Tourism has become an emergent form of domestic tourism with the expanding demand for religious travel along with the accomplishment of other religious obligations. It can also be considered as a catalyst for socio-economic development of the neighbourhood community involved directly and indirectly for the pilgrims during their sojourns at the sacred sites. Though Pilgrimage Tourism is considered as the bottom of the tourism business pyramid, much value can be added through numerous attractive and affordable packages. This paper deals with the concern and challenges of pilgrimage tourism and the impact of cultural heritage in southern districts of Tamil Nadu. Prospects of religious tourists and the impact of cultural heritage are also explored in this research paper

Impact of social media on e-tourism: a critical analysis of determinants of decision making/ V. Sivakumar ... [et al.]

E-Tourism is an emerging trend among the other e-commerce market. Availability of online tourism services has transformed the traditional approach of people in planning their tours and it engage nearly three-fourth of e-commerce share in India. Social media has boomed as the new mode to connect people thus leveraging the impact of social media platform to promote tourism products has established to be an excellent strategy. Social networking sites such as blogs, micro blogs, consumer review sites, content community sites with maximum number of hits, wikis, internet forums and location based social media enable the users to communicate in a way to achieve information search, decision-making and also used by the service providers to achieve promoting tourism services. Exploratory research on the impact of social media in tourism is still in infancy. This paper reports on an online research to establish the various determinants of decision making on using social media for availing tourism services. Research tool is developed based on the extensive review of literature and an online survey is made among the users of relevant social media sites. The data is collected and quantitatively analysed to derive significant factors affecting the decision making of tourists. The authors would also like to acknowledge the funding under RUSA 2.0 Scheme of MHRD, Govt of India

Rapid production of therapeutic proteins using plant system

Plant molecular farming is simply defined as the production of proteins therapeutics (PT) in plants, which involves transient gene expression in plants and purification of expressed protein to a great scale for diagnosis, treatment and other applications.  This is therapid,economical, safe and reproducible approach for the production of PTas compared to bacterial and mammalian systems. Protein yield and post-translational modifications are the major roadblocks that can be overcome byhigh expression strategies includes over expression constructs, suitable plant host systems and glycoengineering of proteins. The inherent ability of ideally producing safe, functional protein is the most striking phenomenon recognized by the pharmaceutical industries and developed many therapeutic products within few weeks to meet escalating demands during pandemic/epidemic outbreaks recentl

Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation

Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age-related chronic diseases. Since this damage often occurs spontaneously, it has traditionally been regarded as untreatable, with typical therapeutic strategies targeting genes or enzymes being ineffective in this domain. In this report, we demonstrate that an antibody targeting the isoDGR damage motif in lung tissue can guide immune clearance of harmful damaged proteins in vivo, effectively reducing age-linked lung inflammation. We observed age-dependent accumulation of the isoDGR motif in human lung tissues, as well as an 8-fold increase in isoDGR-damaged proteins in lung fibrotic tissues compared with healthy tissue. This increase was accompanied by marked infiltration of CD68+/CD11b + macrophages, consistent with a role for isoDGR in promoting chronic inflammation. We therefore assessed isoDGR function in mice that were either naturally aged or lacked the isoDGR repair enzyme. IsoDGR-protein accumulation in mouse lung tissue was strongly correlated with chronic inflammation, pulmonary edema, and hypoxemia. This accumulation also induced mitochondrial and ribosomal dysfunction, in addition to features of cellular senescence, thereby contributing to progressive lung damage over time. Importantly, treatment with anti-isoDGR antibody was able to reduce these molecular features of disease and significantly reduced lung pathology in vivo