User's guide for Skylab dynamics program, SKYDYN

This user's manual describes the capabilities, required input data, and resulting output of SKYDYN, version of the 6 degree-of-freedom digital program REENTR which was extensively modified for the Honeywell CP-V system and was tailored to the specfic requirements for SKYLAB

Reflection positivity and invertible topological phases

We implement an extended version of reflection positivity (Wick-rotated unitarity) for invertible topological quantum field theories and compute the abelian group of deformation classes using stable homotopy theory. We apply these field theory considerations to lattice systems, assuming the existence and validity of low energy effective field theory approximations, and thereby produce a general formula for the group of Symmetry Protected Topological (SPT) phases in terms of Thom's bordism spectra; the only input is the dimension and symmetry group. We provide computations for fermionic systems in physically relevant dimensions. Other topics include symmetry in quantum field theories, a relativistic 10-fold way, the homotopy theory of relativistic free fermions, and a topological spin-statistics theorem.Comment: 136 pages, 16 figures; minor changes/corrections in version 2; v3 major revision; v4 minor revision: corrected proof of Lemma 9.55, many small changes throughout; v5 version for publication in Geometry & Topolog

The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer

RNA-binding proteins (RBPs) are increasingly identified as post-transcriptional drivers of cancer progression. The RBP LARP1 is an mRNA stability regulator, and elevated expression of the protein in hepatocellular and lung cancers is correlated with adverse prognosis. LARP1 associates with an mRNA interactome that is enriched for oncogenic transcripts. Here we explore the role of LARP1 in epithelial ovarian cancer, a disease characterized by the rapid acquisition of resistance to chemotherapy through the induction of pro-survival signalling. We show, using ovarian cell lines and xenografts, that LARP1 is required for cancer cell survival and chemotherapy resistance. LARP1 promotes tumour formation in vivo and maintains cancer stem cell-like populations. Using transcriptomic analysis following LARP1 knockdown, cross-referenced against the LARP1 interactome, we identify BCL2 and BIK as LARP1 mRNA targets. We demonstrate that, through an interaction with the 3 untranslated regions (3 UTRs) of BCL2 and BIK, LARP1 stabilizes BCL2 but destabilizes BIK with the net effect of resisting apoptosis. Together, our data indicate that by differentially regulating the stability of a selection of mRNAs, LARP1 promotes ovarian cancer progression and chemotherapy resistance

Narrow band cross-correlation analysis of fluctuating pressures beneath a turbulent boundary layer

Selected band cross correlation analysis of fluctuating pressures under turbulent boundary layer flo