Tom Brown in South Africa

Inaugural lecture delivered at Rhodes UniversityRhodes University Libraries (Digitisation

Analisa Kinerja Bandul Vertikal dengan Model Plat pada PLTGL

Sumber energi seperti energi fosil yang semakin menipis. Hal ini mendorong semua pihak untuk dapat menjadi lebih baik hingga ilmu yang terdapat didalam dunia perkapalan dapat melahirkan inovasi terbaru, salah satunya adalah pembangkit listrik tenaga gelombang laut – sistem bandulan. Ponton yang menggunakan sistem bandul adalah salah satu alat yang digunakan untuk mengkonversi dari energy laut menjadi energi listrik. Dalam kajian ini menggunakan kondisi uji onshore tanpa menggunakan ballast dan uji off-shore dengan ballas. Dari kajian ini didapatkan banyaknya putaran yang dapat dihasilkan bandul dengan variasi bentuk sudut juring, tebal plat juring dan sudut kemiringan ponton. Untuk uji on-shore daya terbesar didapatkan pada pengujian dengan menggunakan sudut juring 60 o, tebal 3 mm,sudut kemiringan 60 o daya yang dihasilkan 0.107 watt. Untuk pengujian offshore pada ballas 12 cm, 15 cm,17.5 cm, daya terbesar dihasilkan pada ballas dengan daya 0.124 watt pada juring, tebal, dan sudut kemiringan yang sama dengan pengujian onshore. Jumlah putaran dengan waktu, pada pengujian on-shore yang menghasilkan nilai paling besar pada juring dengan sudut 45 o, tebal 2 mm sudut kemiringan 45 o nilai yang didapatkan 1,176 rad/s. Pada pengjuain off-shore paling besar ada pada ballas 17.5 dengan 1.93 rad/s

Seizure in later life: an ode to the elderly

Background: Seizure disorder and epilepsy are one of the common presenting symptoms to an emergency department for geriatric population. Cerebrovascular accident, metabolic derangement, trauma, neurodegenerative diseases, tumor, infections and psychiatric illnesses add up to the frequent etiological spectrum of seizure in elderly. Objective of current study was to describe clinical and etiological spectrum of seizures in later life.Methods: This retrospective study was conducted from medical records of 227 cases of elderly subjects presenting with seizure to emergency department, during a period of 3 years (2010-2013).  Results: Most common age group involved was 65-75 years. Mean age of subjects included in the study was 68.13 ± 23.38 years. The most common etiology was cerebrovascular disorders 132 (58.14%), followed by CNS tumor in 16 (07.04%), hypoglycemia in 14 (06.16%), infections 14 (06.16%), substance abuse 12 (05.28%) and trauma 10 (04.40%). The most common presentation was with focal seizures, with 119 (52.42%) subjects whereas 82 (36.12%) presented with generalized tonic clonic seizure, 20 (08.81%) with generalized tonic seizure and 05 (02.20%) with absence seizures.Conclusion: The present study aims at pointing out the different clinical features and etiologies of geriatric seizures, thereby lets the reader have a head start with the management of an elderly patient presenting with seizure.

Alveolar rhabdomyosarcoma in children with histomorphological review

Rhabdomyosarcomas (RMS) are aggressive malignant neoplasm of mesenchymal origin, related to skeletal muscle lineage. These are the most common soft tissue tumors in children. The diagnosis is made by microscopic analysis and ancillary techniques like immunohistochemistry, electron microscopy, cytogenetics and molecular biology. We encountered a case of a 03 years old child who presented with a tender, reddish, soft swelling over cheek for three weeks. The FNAC was reported as a small round cell tumor, Probably Primitive Neuroectodermal Tumor (PNET). The biopsy of tumor revealed a small round cell tumor with an alveolar pattern. Tumor giant cells were absent and mitotic figures were infrequent. Hence, differentials of alveolar rhabdomyosarcoma and PNET were rendered. Immunohistochemistry (IHC) demonstrated desmin positivity. Thus, a final diagnosis of alveolar rhabdomyosarcoma was offered

Teaching introductory undergraduate Physics using commercial video games

Commercial video games are increasingly using sophisticated physics simulations to create a more immersive experience for players. This also makes them a powerful tool for engaging students in learning physics. We provide some examples to show how commercial off-the-shelf games can be used to teach specific topics in introductory undergraduate physics. The examples are selected from a course taught predominantly through the medium of commercial video games.Comment: Accepted to Physics Education, Fig1 does not render properly in this versio

The nature of phenotypic variation in Pavlovian conditioning

Pavlovian conditioning procedures result in dramatic individual differences in the topography of learnt behaviors in rats: When the temporary insertion of a lever into an operant chamber is paired with food pellets, some rats (known as sign-trackers) predominantly interact with the lever, while others (known as goal-trackers) predominantly approach the food well. Two experiments examined the sensitivity of these two behaviors to changing reinforcement contingencies in groups of males and female rats exhibiting the different phenotypes (i.e., sign-trackers and goal-trackers). In both phenotypes, behavior oriented to the food well was more sensitive to contingency changes (e.g., a reversal in which of two levers was reinforced) than was lever-oriented behavior. That is, the nature of the two behaviors differed independently of the rats in which they were manifest. These results indicate that the behavioral phenotypes reflect the parallel operation of a stimulus-stimulus associative process that gives rise to food-well activity and a stimulus-response process that gives rise to leveroriented activity, rather than the operation of a single process (e.g., stimulus-stimulus) that generates both behaviors

Joint generative model for fMRI/DWI and its application to population

Author Manuscript 2011 March 12. 13th International Conference, Beijing, China, September 20-24, 2010, Proceedings, Part IWe propose a novel probabilistic framework to merge information from DWI tractography and resting-state fMRI correlations. In particular, we model the interaction of latent anatomical and functional connectivity templates between brain regions and present an intuitive extension to population studies. We employ a mean-field approximation to fit the new model to the data. The resulting algorithm identifies differences in latent connectivity between the groups. We demonstrate our method on a study of normal controls and schizophrenia patients.National Alliance for Medical Image Computing (U.S.) (NIH NIBIBNAMICU54-EB005149)Neuroimaging Analysis Center (U.S.) (NIH NCRR NAC P41-RR13218)National Institutes of Health (U.S.) (Grant R01MH074794)National Defense Science and Engineering Graduate FellowshipNational Science Foundation (U.S.) (CAREER Grant 0642971

Can we do better? A qualitative study in the East of England investigating patient experience and acceptability of using the faecal immunochemical test in primary care.

OBJECTIVES: The faecal immunochemical test (FIT) is increasingly used in UK primary care to triage patients presenting with symptoms and at different levels of colorectal cancer risk. Evidence is scarce on patients' views of using FIT in this context. We aimed to explore patients' care experience and acceptability of using FIT in primary care. DESIGN: A qualitative semi-structured interview study. Interviews were conducted via Zoom between April and October 2020. Transcribed recordings were analysed using framework analysis. SETTING: East of England general practices. PARTICIPANTS: Consenting patients (aged ≥40 years) who presented in primary care with possible symptoms of colorectal cancer, and for whom a FIT was requested, were recruited to the FIT-East study. Participants were purposively sampled for this qualitative substudy based on age, gender and FIT result. RESULTS: 44 participants were interviewed with a mean age 61 years, and 25 (57%) being men: 8 (18%) received a positive FIT result. Three themes and seven subthemes were identified. Participants' familiarity with similar tests and perceived risk of cancer influenced test experience and acceptability. All participants were happy to do the FIT themselves and to recommend it to others. Most participants reported that the test was straightforward, although some considered it may be a challenge to others. However, test explanation by healthcare professionals was often limited. Furthermore, while some participants received their results quickly, many did not receive them at all with the common assumption that 'no news is good news'. For those with a negative result and persisting symptoms, there was uncertainty about any next steps. CONCLUSIONS: While FIT is acceptable to patients, elements of communication with patients by the healthcare system show potential for improvement. We suggest possible ways to improve the FIT experience, particularly regarding communication about the test and its results