Phase Velocities and Angle of Inclination for Frequency Components in Fully Developed Turbulent Flow Through Pipes

Measurements of phase shift and coherence between the streamwise velocity fluctuations at two sensors placed very close to each other have been made in fully developed turbulent flow in a smooth pipe. For the frequencies where the √coherence is near unity (i.e. the correlation between the frequency components is near unity) the phase shifts have been related to the phase velocities and angle of inclination of a frozen pattern of turbulence. Several other quantities such as intensities, energy spectral densities and mean velocities have also been obtained from the data taken with each sensor and these are in good agreement with previously found values. Probability densities of the streamwise velocity fluctuations were calculated and appear to be positively skewed near the wall and negatively skewed in the central region of the flow. The phase shift measurements indicate that the phase velocities of all but the lowest frequency components are near and somewhat below the local mean velocity in the central region of the pipe and that the disturbance fronts are perpendicular to the wall. Near the wall all the disturbances seem to be inclined - the lower frequencies making smaller angles with the wall than the higher frequencies. The angles of inclination of all disturbances increase with distance from the wall. The phase velocity appears higher than the local mean velocity in this region

Bibliography of reversed-phase partition chromatography

BIBLIOGRAPHY OF REVERSED-PHASE PARTITION CHROMATOGRAPH

A Metabolic Hypothesis for the Evolution of Temperature Effects on the Arterial PCO2 and pH of Vertebrate Ectotherms

Body temperature increases in ectothermic vertebrates characteristically lead to both increases in arterial PCO2 (PaCO2) and declines in resting arterial pH (pHa) of about 0.017 pH units/°C increase in temperature. This ‘alphastat’ pH pattern has previously been interpreted as being evolutionarily-driven by the maintenance of a constant protonation state on the imidazole moiety of histidine protein residues, hence stabilizing protein structure-function. Analysis of the existing data for interclass responses of ectothermic vertebrates show different degrees of PaCO2 increases and pH declines with temperature between the classes with reptiles\u3eamphibians\u3efish. The PaCO2 at the temperature where maximal aerobic metabolism (VO2max) is achieved is significantly and positively correlated with temperature for all vertebrate classes. For ectotherms, the PaCO2 where VO2max is greatest is also correlated with VO2max indicating there is an increased driving force for CO2 efflux that is lowest in fish, intermediate in amphibians and highest in reptiles. The pattern of increased PaCO2 and the resultant reduction of pHa to increased body temperature would serve to increase CO2 efflux, O2 delivery, blood buffering capacity and maintain ventilatory scope. This represents a new hypothesis for the selective advantage of arterial pH regulation from a systems physiology perspective in addition to the advantages of maintenance of protein structure-function

Direct lateral maneuvers in hawkmoths

ABSTRACTWe used videography to investigate direct lateral maneuvers, i.e. ‘sideslips’, of the hawkmoth Manduca sexta. M. sexta sideslip by rolling their entire body and wings to reorient their net force vector. During sideslip they increase net aerodynamic force by flapping with greater amplitude, (in both wing elevation and sweep), allowing them to continue to support body weight while rolled. To execute the roll maneuver we observed in sideslips, they use an asymmetric wing stroke; increasing the pitch of the roll-contralateral wing pair, while decreasing that of the roll-ipsilateral pair. They also increase the wing sweep amplitude of, and decrease the elevation amplitude of, the contralateral wing pair relative to the ipsilateral pair. The roll maneuver unfolds in a stairstep manner, with orientation changing more during downstroke than upstroke. This is due to smaller upstroke wing pitch angle asymmetries as well as increased upstroke flapping counter-torque from left-right differences in global reference frame wing velocity about the moth's roll axis. Rolls are also opposed by stabilizing aerodynamic moments from lateral motion, such that rightward roll velocity will be opposed by rightward motion. Computational modeling using blade-element approaches confirm the plausibility of a causal linkage between the previously mentioned wing kinematics and roll/sideslip. Model results also predict high degrees of axial and lateral damping. On the time scale of whole and half wing strokes, left-right wing pair asymmetries directly relate to the first, but not second, derivative of roll. Collectively, these results strongly support a roll-based sideslip with a high degree of roll damping in M. sexta.Summary: We show that hawkmoths fly sideways by rolling in the direction of movement, adding a left- or right-ward component to their net lift vector. The underlying roll maneuvers are produced from a suite of asymmetric wing kinematic changes and are heavily damped

Ricci flows, wormholes and critical phenomena

We study the evolution of wormhole geometries under Ricci flow using numerical methods. Depending on values of initial data parameters, wormhole throats either pinch off or evolve to a monotonically growing state. The transition between these two behaviors exhibits a from of critical phenomena reminiscent of that observed in gravitational collapse. Similar results are obtained for initial data that describe space bubbles attached to asymptotically flat regions. Our numerical methods are applicable to "matter-coupled" Ricci flows derived from conformal invariance in string theory.Comment: 8 pages, 5 figures. References added and minor changes to match version accepted by CQG as a fast track communicatio

COVID-19: Clean up on IL-6

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the latest threat to global health security, and the pressure to identify effective therapeutics during this pandemic is immense. This stress has led to the use of unproven therapies with greater than minimal risk. One example is the use of IL-6 receptor antagonists. After an early report of a “cytokine storm” in patients with coronavirus disease (COVID-19), there is increased interest in anti–IL-6 therapy as a treatment option, with ill-defined criteria for use (1)

Relationships among Members of the Genus Myxobolus (Myxozoa: Bilvalvidae) Based on Small Subunit Ribosomal DNA Sequences

Sequences representing similar to 1,700 base pairs of the 18S rRNA gene from 10 different species in the genus Myxobulus were found to group them into 3 clusters that showed little correlation with spore morphology and size or host specificity, criteria currently used for both higher and lower taxonomic placements in the Myxozoa. Of the phenotypic criteria examined, tissue tropism was most correlated with the rRNA groupings observed. Spores of similar size and shape (Myxobolus cerebralis vs. Myxobolus squamalis) were distantly related in some instances, whereas spores with divergent morphology and size were some times found to be closely related (M. cerebralis and Myxobolus insidiosus). These initial investigations into the phylogenetic relationships of putative members of the genus Myxobolus clearly indicate the potential limitations of groupings based on size and morphological properties of the spores and host species infected. We propose that 18S rRNA gene sequences, combined with information on tissue tropism, host species infected, and developmental cycles in the fish and alternate host (when and if known) be given greater consideration in taxonomic placements of myxosporeans

Operational Water Forecast Ability of the HRRR-iSnobal Combination: An Evaluation to Adapt into Production Environments

Operational water-resource forecasters, such as the Colorado Basin River Forecast Center (CBRFC) in the Western United States, currently rely on historical records to calibrate the temperature-index models used for snowmelt runoff predictions. This data dependence is increasingly challenged, with global and regional climatological factors changing the seasonal snowpack dynamics in mountain watersheds. To evaluate and improve the CBRFC modeling options, this work ran the physically based snow energy balance iSnobal model, forced with outputs from the High-Resolution Rapid Refresh (HRRR) numerical weather prediction model across 4 years in a Colorado River Basin forecast region. Compared to in situ, remotely sensed, and the current operational CBRFC model data, the HRRR-iSnobal combination showed well-reconstructed snow depth patterns and magnitudes until peak accumulation. Once snowmelt set in, HRRR-iSnobal showed slower simulated snowmelt relative to observations, depleting snow on average up to 34 d later. The melting period is a critical component for water forecasting. Based on the results, there is a need for revised forcing data input preparation (shortwave radiation) required by iSnobal, which is a recommended future improvement to the model. Nevertheless, the presented performance and architecture make HRRR-iSnobal a promising combination for the CBRFC production needs, where there is a demonstrated change to the seasonal snow in the mountain ranges around the Colorado River Basin. The long-term goal is to introduce the HRRR-iSnobal combination in day-to-day CBRFC operations, and this work created the foundation to expand and evaluate larger CBRFC domains