Surrogate-Assisted Artificial Immune Systems for Expensive Optimization Problems

Non

Witnessing and re-enacting in Cambodia: reflection on shifting testimonies

Thirty years after the collapse of the Khmer Rouge regime (1975-1979) how do Cambodians cope with the traumatic legacy of Pol Pot's reign of terror? What forms does witnessing take on in post-socialist and transitional Cambodia as senior Khmer Rouge leaders await prosecution at the Cambodian Tribunal? The paper examines aspects of witnessing in today's Cambodia, expressing each in its own way the idea of the 'shifting' of witnessing: the transformation of testimonies due to time passing and contrasted systems of justice through a comparison of testimonies in the trial of the 'Pol Pot/Ieng Sary clique' (1979) and the current Cambodian Tribunal; the complex forms of witnessing emerging from participatory projects developed with Western authors in 'We want (u) to know' (documentary movie made by an international film crew with the inhabitants of the village of Thnol Lok in 2009) and 'Breaking the silence' (theatre play realised by the Dutch dramaturge Annemarie Prins that premiered in Phnom Penh in 2009 and toured Cambodia in the following years); the relationship between documentary and legal forms of witnessing through the example of Vann Nath, a survivor of S-21/Tuol Sleng, the prison where the Khmer Rouge tortured and killed thousands of their fellow countrymen. The paper analyses the difficulty Western organisers of participatory projects experienced in applying the hybrid model of transitional justice to sociocultural contexts of witnessing. Nevertheless it points out their contribution to processes of 'recognition beyond recognition' in which cultural differences in coming to terms with historical trauma are expressed and recorded

Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks

Exposure to environmental chemicals and drugs may have a negative effect on human health. A better understanding of the molecular mechanism of such compounds is needed to determine the risk. We present a high confidence human protein-protein association network built upon the integration of chemical toxicology and systems biology. This computational systems chemical biology model reveals uncharacterized connections between compounds and diseases, thus predicting which compounds may be risk factors for human health. Additionally, the network can be used to identify unexpected potential associations between chemicals and proteins. Examples are shown for chemicals associated with breast cancer, lung cancer and necrosis, and potential protein targets for di-ethylhexyl-phthalate, 2,3,7,8-tetrachlorodibenzo-p-dioxin, pirinixic acid and permethrine. The chemical-protein associations are supported through recent published studies, which illustrate the power of our approach that integrates toxicogenomics data with other data types

Mutational analysis of the HTLV-Itrans-activator, Tax

AbstractThe gene coding for thetrans-activating factor (Tax) of the human T-cell leukemia virus, type I (HTLV-I) was mutagenized in vitro using oligonucleotide-directed mutagenesis and recombinant DNA techniques. All except one of the mutagenizedtax constructs failed totrans-activate the HTLV-I LTR in a eukaryotic test system. Moreover, negative Tax mutant Arg-39→Gly was found to betrans-dominant. This observation suggests that Tax contains distinct functional domains mediating different interactions of the protein in the process oftrans-activation