Primary Epstein-Barr virus infection in a 40-day-old infant

Most cases of primary Epstein-Barr virus (EBV) infection during infancy and early childhood are mild or subclinical; therefore, the diagnosis of an EBV infection is not performed easily in this age group. Infectious mononucleosis (IM) is rarely reported during infancy. We report a 40-day-old infant with cervical node enlargement, cough, and coryza symptoms who was finally identified as having a case of primary IM based on the patient's clinical features and serological tests. © 2013 - IOS Press and the authors. All rights reserved

An exploration of obesity: childhood onset obesity and adult onset obesity

The prevalence of obesity in the United States can be considered alarming, given its dramatic increase over the past twenty years. A large percentage of the obese population suffers from both medical and psychological side effects. This study focused on how non-obese and obese individuals perceive one\u27s own body. Based on research, it was hypothesized that obese individuals are more likely than non-obese individuals to perceive one\u27s body negatively. It was also hypothesized that obese individuals who suffer from childhood onset obesity as opposed to adult onset obesity are more likely to perceive one\u27s body negatively. Participants were recruited from a medical office located in a middle-upper class suburban town of South Jersey. Body shape attitudes were attained through the Body Shape Questionnaire. Through a One-Way ANOVA, it was found that non-obese females view their bodies more favorably than obese females. No significant results were found to support a relationship between childhood and adult onset obesity

Tessier number 30 clefts with congenital heart defects

Introduction: Midline cleft of mandible, classified as Tessier 30 clefts is extremely rare, with less than 100 reported cases in the latest studies. Variations in severity and associated malformations have been reported before. Case Presentation: In this report, we present the first documented Iranian case of Tessier 30 with median cleft of lower lip and bifid tongue concomitant with congenital heart defects. Conclusions: We explain embryologic origin, differential diagnosis, other associated anomalies and its treatment by reviewing literature. © 2015, Iranian Red Crescent Medical Journal

Mechanisms of airfoil noise near stall conditions

The focus of this paper is on investigating the noise produced by an airfoil at high angles of attack over a range of Reynolds number Re≈2×10⁵–4×10⁵. The objective is not modeling this source of noise but rather understanding the mechanisms of generation for surface pressure fluctuations, due to a separated boundary layer, that are then scattered by the trailing edge. To this aim, we use simultaneous noise and surface pressure measurement in addition to velocimetric measurements by means of hot wire anemometry and time-resolved particle image velocimetry. Three possible mechanisms for the so-called “separation-stall noise” have been identified in addition to a clear link between far-field noise, surface pressure, and velocity fields in the noise generation

Investigating the Levels of Shed Extracellular Domain of HER2 Protein in the Sera of Bladder Cancer Patients

Background: Receptor tyrosine-protein kinase ERBB2, also known as human epidermal growth factor receptor-2 (HER2), is heterogeneously expressed in a variety of human cancers, including bladder cancer. Based on previous studies that show its association with bladder cancer progression, HER2 has been included in novel multiplatform biomarkers for prediction of bladder cancer prognosis. However, the clinical significance of HER2 status remains underinvestigated and poorly linked to the patients’ clinicopathological features. Here, we aim to scrutinize the levels of the extracellular domain of HER2 in the sera of bladder cancer patients and correlate these levels with clinicopathological features of the tumor. Methods: In the present analytical cross-sectional study, we enrolled 60 pathologically confirmed bladder cancer patients along with 20 age-sex matched healthy controls, and compared their serum HER2 levels as measured by enzyme-linked immunosorbent assay. Results:We observed no statistically significant difference when comparing the levels of HER2 in the sera of cases and controls (P>0.05). Interestingly, serum HER2 levels of controls were higher than bladder cancer patients who had lymph node metastasis (P=0.036). Serum levels of HER2 were also higher in controls than bladder cancer patients with perineural invasion (P=0.028). We observed significantly higher HER2 serum levels in transitional cell carcinoma patients in comparison to non-transitional cell carcinoma patients (P=0.016). Conclusion: Our observations are suggestive of the absence of any association between bladder cancer prognostic factors and serum HER2 levels. To draw any definitive conclusion, further studies with larger sample sizes that examine the presence of neutralizing auto-antibodies against serum HER2, immunohistochemistry examination of HER2 in bladder tumor and lymph node samples, and urinary HER2 levels, along with measurement of its serum levels would be helpful

On the manipulation of flow and acoustic fields of a blunt trailing edge aerofoil by serrated leading edges

This paper employs serrated leading edges to inject streamwise vorticity to the downstream boundary layer and wake to manipulate the flow field and noise sources near the blunt trailing edge of an asymmetric aerofoil. The use of a large serration amplitude is found to be effective to suppress the first noise source—bluntness-induced vortex shedding tonal noise—through the destruction of the coherent eigenmodes in the wake. The second noise source is the instability noise, which is produced by the interaction between the boundary layer instability and separation bubble near the blunt edge. The main criterion needed to suppress this noise source is related to a small serration wavelength because, through the generation of more streamwise vortices, it would facilitate a greater level of destructive interaction with the separation bubble. If the leading edge has both a large serration amplitude and wavelength, the interaction between the counter-rotating vortices themselves would trigger a turbulent shear layer through an inviscid mechanism. The turbulent shear layer will produce strong hydrodynamic pressure fluctuations to the trailing edge, which then scatter into broadband noise and transform into a trailing edge noise mechanism. This would become the third noise source that can be identified in several serrated leading edge configurations. Overall, a leading edge with a large serration amplitude and small serration wavelength appears to be the optimum choice to suppress the first and second noise sources and, at the same time, avoid the generation of the third noise source

Optimization of leading-edge undulation of a NACA 65(12)-10 aerofoil for noise reduction and aerodynamic enhancement

Leading-edge undulations or tubercles of humpback whale flippers have been known as one of biomimetic technologies adaptable to flow control of aerofoils, particularly at post stall conditions. These leading-edge undulations are also known to reduce noise resulting from an interaction with on-coming turbulence. We have recently carried out a parametric study of a NACA 65(12)-10 aerofoil with a view to optimise the amplitude and the wavelength of leading-edge undulations for noise reduction and aerodynamic enhancement. A 3x3 test matrix composing of three amplitudes (h = 3%, 6% and 12% chord) and three wavelengths (? = 10%, 20% and 30% chord) was used in the investigation, where lift, drag and noise were measured at the Reynolds number of 105. In this test, a turbulence-generating grid was installed at the inlet of the test section to increase the turbulence level in the freestream and to promote transition to turbulence near the leading edge of aerofoils without a need for a trip device. Within the test matrix considered, we found that the best improvement in CL,max is given with the greatest wavelength and amplitude, whereas the maximum noise reduction is obtained with the small wavelength and the large amplitude

Aerodynamic and Aeroacoustic Optimization of Leading-Edge Undulation of a NACA 65(12)-10 Airfoil

Experimental studies of a NACA 65(12)-10 airfoil with a sinusoidal leading-edge undulation (LEU) were carried out to simultaneously optimize its aerodynamic and aeroacoustic performances by considering the attached as well as the separated flow at the effective Reynolds number of 106, where the maximum lift was increased without sacrificing drag or overall noise at near- and poststall angles. Further aerodynamic and aeroacoustic tests indicated that a combination of LEU wavelength λ/c=30% and amplitude h/c=6% gave an optimum LEU by considering the aerodynamic performance as well as the noise reduction. Particle image velocimetry measurements of the flow over the optimized airfoil showed biperiodic velocity fluctuations downstream of the LEU peaks that were associated with unsteady stall cell structure near the trailing edge

Leading edge serrations for the reduction of aerofoil self-noise at low angle of attack, pre-stall and post-stall conditions

This paper addresses the usefulness of leading edge serrations for reducing aerofoil self-noise over a wide range of angles of attack. Different serration geometries are studied over a range of Reynolds number (Formula presented.). Design guidelines are proposed that permit noise reductions over most angles of attack. It is shown that serration geometries reduces the noise but adversely effect the aerodynamic performance suggesting that a trade-off should be sought between these two considerations. The self-noise performance of leading edge serrations has been shown to fall into three angle of attack (AoA) regimes: low angles where the flow is mostly attached, moderate angles where the flow is partially to fully separated, and high angles of attack where the flow is fully separated. Leading edge serrations have been demonstrated to be effective in reducing noise at low and high angles of attack but ineffective at moderate angles. The noise reduction mechanisms are explored in each of three angle regimes