1,744 research outputs found
Organizational knowledge transfer through creation, mobilization and diffusion: A case analysis of InTouch within Schlumberger
There is a paucity of theory for the effective management of knowledge transfer within large organisations. Practitioners continue to rely upon ‘experimental’ approaches to address the problem. This research attempts to reduce the gap between theory and application, thereby improving conceptual clarity for the transfer of knowledge.
The paper, through an in-depth case analysis conducted within Schlumberger, studies the adoption of an intranet-based knowledge management (KM) system (called InTouch) to support, strategically align and transfer knowledge resources.
The investigation was undertaken through the adoption of a robust methodological approach (abductive strategy) incorporating the role of technology as an enabler of knowledge management application. Consequently, the study addressed the important question of translating theoretical benefits of KM into practical reality.
The research formulates a set of theoretical propositions which are seen as key to the development of an effective knowledge based infrastructure. The findings identify 30 generic attributes that are essential to the creation, mobilisation and diffusion of organisational knowledge.
The research makes a significant contribution to identifying a theoretical and empirically based agenda for successful intranet-based KM which will be of benefit to both the academic and practitioner communities. The paper also highlights and proposes important areas for further research
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Strategies, contributions and inhibitors of information systems to organizational competitiveness: An empirical analysis within the Caribbean
The study examines the impact of Information Systems (IS) through a consideration of improved competitiveness within a multi-business Caribbean firm. The methodology draws on a participant-observer approach for data collection and compares the application of IS by three business units within each of three organizations. It is argued that while there is already a substantial amount of research on IS effectiveness its value in the context of developing countries such as those of the Caribbean will be most significant. In this context firms are perceived to face more constraints than in developed countries so there is a need to explicitly recognize the effects of ‘inhibitors’.
The study finds that for two of these businesses IS can be shown to have contributed to improved competitiveness, while the third had a less satisfactory experience. Analysis of the data revealed that in the two business units where IS contributed the units had been able to improve specific business processes in pursuit of identified competitive strategies. In the unit that did not derive such advantages, limitations in the functionality of the core application combined with insufficient adjustment of business processes, led to the unsatisfactory results. It is also observed that the explanatory value of the empirical analysis is enhanced if we identify inhibitors of IS for competitive advantage and make their effects more explicit
Factors impacting knowledge transfer success in information systems outsourcing
Despite increased research interest on knowledge transfer in information systems (IS) outsourcing, the field still lacks sound and holistic understanding of the key factors influencing knowledge transfer success. The present paper attempts to provide a synthesis of existing theoretical perspectives and empirical findings related to the factors that facilitate or hamper knowledge transfer success in IS outsourcing. The data collection method is discussed and the key findings are presented. Conclusion is drawn and further research is suggested
A versatile microfadometer for lightfastness testing and pigment identification
The design and experimental method for the use of a novel instrument for lightfastness measurements on artwork is presented. The new microfadometer design offers increased durability and portability over the previous, published design, broadening the scope of locations at which data can be acquired. This reduces the need for art handling or transportation in order to gain evidence-based risk assessments for the display of light-sensitive artworks. The instrument focuses a stabilized high powered xenon lamp to a spot 0.25 millimeters (FWHM) while simultaneously monitoring color change. This makes it possible to identify pigments and determine the lightfastness of materials effectively and non-destructively. With 2.59mW or 0.82 lumens (1.7 x107 lux for a 0.25mm focused spot) the instrument is capable of fading Blue Wool 1 to a measured 11 ΔEab value (using CIE standard illuminant D65) in 15 minutes. The temperature increase created by focused radiation was measured to be 3 to 4°C above room temperature. The system was stable within 0.12 ΔEab over 1 hour and 0.31 ΔEab over 7 hours. A safety evaluation of the technique is discussed which concludes that some caution should be employed when fading smooth, uniform areas of artworks. The instrument can also incorporate a linear variable filter. This enables the researcher to identify the active wavebands that cause certain degradation reactions and determine the degree of wavelength dependence of fading. Some preliminary results of fading experiments on Prussian blue samples from the paint box of J. M. W Turner (1755-1851) are presented
Photochemical colour change for traditional watercolour pigments in low oxygen levels
An investigation for light exposure on pigments in low-oxygen environments (in the range 0–5% oxygen) was conducted using a purpose-built automated microfadometer for a large sample set including multiple samples of traditional watercolour pigments from nineteenth-century and twentieth-century sources, selected for concerns over their stability in anoxia. The pigments were prepared for usage in watercolour painting: ground and mixed in gum Arabic and applied to historically accurate gelatine glue-sized cotton and linen-based papers. Anoxia benefited many colorants and no colorant fared worse in anoxia than in air, with the exception of Prussian blue and Prussian green (which contains Prussian blue). A Prussian blue sampled from the studio materials of J.M.W. Turner (1775 − 1851) was microfaded in different environments (normal air (20.9% oxygen) 0, 1, 2, 3.5, or 5% oxygen in nitrogen) and the subsequent dark behaviour was measured. The behaviour of the sample (in normal air, anoxia, and 5% oxygen in nitrogen) proved to be consistent with the 55 separately sourced Prussian blue samples. When exposed to light in 5% oxygen in nitrogen, Prussian blue demonstrated the same light stability as in air (at approximately 21°C and 1 atmosphere). Storage in 5% oxygen is proposed for ‘anoxic’ display of paper-based artworks that might contain Prussian blue, to protect this material while reducing light-induced damage to other components of a watercolour, including organic colorants and the paper support
The homotopy theory of simplicial props
The category of (colored) props is an enhancement of the category of colored
operads, and thus of the category of small categories. In this paper, the
second in a series on "higher props," we show that the category of all small
colored simplicial props admits a cofibrantly generated model category
structure. With this model structure, the forgetful functor from props to
operads is a right Quillen functor.Comment: Final version, to appear in Israel J. Mat
Development of portable microfading spectrometers for measurement of light sensitivity of materials
Microfading was originally designed for efficiently detecting extremely light-sensitive materials on objects in situ to determine the appropriate exhibition lighting conditions. By focusing an intense beam of light to a tiny submillimetre sized spot and simultaeously monitoring the colour change over time, the fading rate of the material can be measured without producing noticeable damage. The increased intensity of light allows rapid determination of light-fastness of materials. This paper examines an improved design of microfading spectrometer that is easy to assemble, compact, robust, capable of fully automatic acquisition of data with precision control of the fading time to produce higher precision measurements and to allow simultaneous monitoring of colour, spectral reflectance and other changes in real time. The effects of various parameters such as thickness and concentration of paint layer, the binding medium and substrate on the fading rates are examined for selected pigments and found that in certain cases substrates, binding media and thickness can affect the fading rate. Reciprocity in the context of microfading compared with realistic exhibition conditions is examined and found that it breaks down for some pigment
Dynamic concentration of motors in microtubule arrays
We present experimental and theoretical studies of the dynamics of molecular
motors in microtubule arrays and asters. By solving a convection-diffusion
equation we find that the density profile of motors in a two-dimensional aster
is characterized by continuously varying exponents. Simulations are used to
verify the assumptions of the continuum model. We observe the concentration
profiles of kinesin moving in quasi two-dimensional artificial asters by
fluorescent microscopy and compare with our theoretical results.Comment: 4pages, 4 figures revte
Perceptions of childhood immunization in a minority community: Qualitative study
This is the author's accepted manuscript. The final published article is available from the link below. Published article copyright @ The Royal Society of Medicine.Objective - To assess reasons for low uptake of immunization amongst orthodox Jewish families.
Design - Qualitative interviews with 25 orthodox Jewish mothers and 10 local health care workers.
Setting - The orthodox Jewish community in North East London.
Main outcome measures - Identification of views on immunization in the orthodox Jewish community.
Results - In a community assumed to be relatively insulated from direct media influence, word of mouth is nevertheless a potent source of rumours about vaccination dangers. The origins of these may lie in media scares that contribute to anxieties about MMR. At the same time, close community cohesion leads to a sense of relative safety in relation to tuberculosis, with consequent low rates of BCG uptake. Thus low uptake of different immunizations arises from enhanced feelings of both safety and danger. Low uptake was not found to be due to the practical difficulties associated with large families, or to perceived insensitive cultural practices of health care providers.
Conclusions - The views and practices of members of this community are not homogeneous and may change over time. It is important that assumptions concerning the role of religious beliefs do not act as an obstacle for providing clear messages concerning immunization, and community norms may be challenged by explicitly using its social networks to communicate more positive messages about immunization. The study provides a useful example of how social networks may reinforce or challenge misinformation about health and risk and the complex nature of decision making about children's health.City and
Hackney Teaching
Primary Care Trus
The structure of the ternary Eg5–ADP–ispinesib complex
The human kinesin Eg5 is responsible for bipolar spindle formation during early mitosis. Inhibition of Eg5 triggers the formation of monoastral spindles, leading to mitotic arrest that eventually causes apoptosis. There is increasing evidence that Eg5 constitutes a potential drug target for the development of cancer chemotherapeutics. The most advanced Eg5-targeting agent is ispinesib, which exhibits potent antitumour activity and is currently in multiple phase II clinical trials. In this study, the crystal structure of the Eg5 motor domain in complex with ispinesib, supported by kinetic and thermodynamic binding data, is reported. Ispinesib occupies the same induced-fit pocket in Eg5 as other allosteric inhibitors, making extensive hydrophobic interactions with the protein. The data for the Eg5-ADP-ispinesib complex suffered from pseudo-merohedral twinning and revealed translational noncrystallographic symmetry, leading to challenges in data processing, space-group assignment and structure solution as well as in refinement. These complications may explain the lack of available structural information for this important agent and its analogues. The present structure represents the best interpretation of these data based on extensive data-reduction, structure-solution and refinement trials
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