Health education and the control of urogenital schistosomiasis: assessing the impact of the Juma na Kichocho comic-strip medical booklet in Zanzibar

Endeavours to control urogenital schistosomiasis on Unguja Island (Zanzibar) have focused on school-aged children. To assess the impact of an associated health education campaign, the supervised use of the comic-strip medical booklet Juma na Kichocho by Class V pupils attending eighteen primary schools was investigated. A validated knowledge and attitudes questionnaire was completed at baseline and repeated one year later following the regular use of the booklet during the calendar year. A scoring system (ranging from 0.0 to 5.0) measured children's understandings of schistosomiasis and malaria, with the latter being a neutral comparator against specific changes for schistosomiasis. In 2006, the average score from 751 children (328 boys and 423 girls) was 2.39 for schistosomiasis and 3.03 for malaria. One year later, the score was 2.43 for schistosomiasis and 2.70 for malaria from 779 children (351 boys and 428 girls). As might be expected, knowledge and attitudes scores for schistosomiasis increased (+0.05), but not as much as originally hoped, while the score for malaria decreased (-0.33). According to a Kolmogorov-Smirnov test, neither change was statistically significant. Analysis also revealed that 75% of school children misunderstood the importance of reinfection after treatment with praziquantel. These results are disappointing. They demonstrate that it is mistaken to assume that knowledge conveyed in child-friendly booklets will necessarily be interpreted, and acted upon, in the way intended. If long-term sustained behavioural change is to be achieved, health education materials need to engage more closely with local understandings and responses to urogenital schistosomiasis. This, in turn, needs to be part of the development of a more holistic, biosocial approach to the control of schistosomiasis

Improved crowd psychological model and control

The behavior of human crowd is an interesting phenomenon in which individuals are set as a collection that comprises of a highly dynamic social group. The crowd behaviors have been investigated by researchers over the years. Recent works include the study in modeling and controlling of the dynamic psychological behavior of crowds such as students’ behavior in a classroom or people’s behavior in a one-dimensional queue. In this paper, an improved version of the psychological crowd model has been proposed, where the social interaction between two individuals in a crowd is represented by a weightage, called the weight of social interaction. It has been shown that the inclusion of the social interaction weight has allowed social interactions between individuals to be included and results in a more accurate representation of the crowd’s psychological factors propagations. Since the psychological dynamics of crowd is naturally unstable, this paper also discusses the application of two nonlinear control approaches to stabilise the crowd to make it calm. Results show that for a crowd of n number of agents, the single-agent controller gives similar performance with the n-agent controller but with much less resources. The simulation results also show that it takes less amount of time to stabilise a crowd when the crowd model includes social interaction weights

Osteosarcoma of the femur in early adult: a case report

Osteosarcomas are primary malignant tumors of bone that are characterized by the production of osteoid or immature bone by the malignant cells. Osteosarcomas are uncommon tumors. Most articles reveal difficulty in diagnosing osteosarcoma in early stage due to its resemblance to benign lesion. That’s why we prefer to do case report for documentation. Diagnosis of the tumor is important especially in early stages for improving prognosis. This case report is of a 21 years old female who presented at Primary Health Care Centre with swelling above right knee post trauma a month ago. Previously she was diagnosed as Non ossifying fibroma (which is a benign lesion and uncommon to change to malignant lesion) at the same site in 2017.

Rheumatoid arthritis onset after COVID-19 infection: a case report

At the end of 2019, coronavirus disease (COVID-19) outbreak is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Worldwide researchers and physician try to explore the mechanisms of damage induced by virus, they focus on the short-term and long-term immune-mediated consequences induced by the virus infection. Every day discover a new pathological condition induced by virus and new symptoms and disease may occur after recovery from disease. Our case report is 41 years old, Indian lady who presented to our primary health care centre complaining of multiple small hand joints pain, both elbows and knees pain with swelling of them and prolonged morning stiffness, diagnosed seropositive rheumatoid arthritis (RA) (arthritis, positive rheumatoid factor (RF), and X-ray changes) after 1 month recovery from COVID-19 infection. She did not have any joint pain and she had negative RF before COVID-19 infection with no family history of RA

Study of absorption loss effects on acoustic wave propagation in shallow water using different empirical models

Efficient underwater acoustic communication and target locating systems require detailed study of acoustic wave propagation in the sea. Many investigators have studied the absorption of acoustic waves in ocean water and formulated empirical equations such as Thorp's formula, Schulkin and Marsh model and Fisher and Simmons formula. The Fisher and Simmons formula found the effect associated with the relaxation of boric acid on absorption and provided a more detailed form of absorption coefficient which varies with frequency. However, no simulation model has made for the underwater acoustic propagation using these models. This paper reports the comparative study of acoustic wave absorption carried out by means of modeling in MATLAB. The results of simulation have been evaluated using measured data collected at Desaru beach on the eastern shore of Johor in Malaysia. The model has been used to determine sound absorption for given values of depth (D), salinity (S), temperature (T), pH, and acoustic wave transmitter frequency (f). From the results a suitable range, depth and frequency can be found to obtain best propagation link with low absorption loss

Chemical constituents and lipoxygenase inhibitory activity of Piper stylosum Miq.

ABSTRACT. Chemical constituents and lipoxygenase inhibitory activity of the aerial part of Piper stylosum have been studied. Fractionation and purification of the extracts afforded five lignans, identified as yangambin (1), sesamin (2), syringaresinol (3), pinoresinol (4), and medioresinol (5), together with other constituents; 4-allyl resorcinol, β-sitosterol, β-sitostenone, taraxerol, vanilin, and vanilic acid. The structures of these compounds were established by analysis of their spectral data, as compared to that of reported compounds. The lipoxygenase inhibitory activity of the extracts and isolated lignans were also evaluated.               KEY WORDS: Piperaceae, Piper, Piper stylosum, Lignan, Lipoxygenase Bull. Chem. Soc. Ethiop. 2019, 33(3), 587-592.   DOI: https://dx.doi.org/10.4314/bcse.v33i3.1

Chemical constituents and acetylcholinesterase inhibitory activity of Beilschmiedia insignis Gamble

ABSTRACT. Secondary metabolites from natural products are potential sources of acetylcholinesterase inhibitors, which are key enzymes in the treatment of many neurodegenerative diseases. Inspired by the reported activities of alkaloids herein we report the chemical investigation on the chemical constituents from Beilschmiedia insignis and their acetylcholinesterase inhibitory activity. Isolation of the stem bark of B. insignis led to the isolation and identification of five aporphine alkaloids, namely isocorydine (1), norisocorydine (2), (+)-laurotetanine (3), (+)-N-methyllaurotetanine (4), and (+)-boldine (5), together with β-sitosterol (6), β-sitostenone (7), lupeol (8), and lupenone (9). The chemical structures of these compounds were obtained by analysis of their spectroscopic data, as well as the comparison with that of reported data. Acetylcholinesterase inhibitory activity revealed that all isolated alkaloids were found to inhibit AChE with percentage inhibition values ranged from 44.9 to 74.5%. This is the first report on phytochemicals from B. insignis.                     KEY WORDS: Lauraceae, Beilschmiedia insignis, Alkaloid, Acetylcholinesterase, Alzheimer   Bull. Chem. Soc. Ethiop. 2021, 35(3), 685-691. DOI: https://dx.doi.org/10.4314/bcse.v35i3.1

Optimal exit configuration of factory layout for a safer emergency evacuation using crowd simulation model and multi-objective artificial bee colony optimization

This work aims at providing a systematic method in producing a safer and optimal factory layout based on a crowd simulation model and the multi-objective artificial bee colony optimization technique. Apart, from ensuring the efficiency of manufacturing processes in planning a factory layout, it is also important that the safety aspect is taken into account. A factory is usually a closed working area consisting of machines, equipment, assembly lines as well as individual working space and other departments within the factory. In this environment, workers move around in the factory to perform different activities, and hence highly complex crowd behaviours that are influenced by the physical, social and psychological factors of the crowd might take place. Therefore, the layout of the factory must be carefully designed so that efficient movements of people can be obtained. Furthermore, during emergency situations that require efficient evacuation of workers from the factory building, a good factory layout will prevent or minimize the possibility of injuries during the evacuation process. This will reduce the evacuation egress time, which is the quantity used to evaluate the evacuation efficiency and the building's level of safety. One of the techniques to assess the evacuation efficiency of a particular space configuration is by using the crowd simulation model. Recent evidences suggest that the representation of crowd dynamics using a simulation model is useful, where experiments with real humans are too dangerous and not practical to be implemented. This work explains the method to provide optimal exit door configurations for a factory layout by analyzing the crowd evacuation time and the discomfort level, where the proposed optimum exit configurations will be compared with the original configuration for a better evacuation efficiency

Non-infectious Complications of Peritoneal Dialysis among Sudanese Patients: Five Years Experience

Introduction: The technique of Continuous Ambulatory Peritoneal Dialysis (CAPD) is known to be associated with various infectious and non-infectious complications. The latter term includes anatomical/mechanical complications as well as hemoperitoneum, inflow pain, electrolyte disturbances, metabolic derangements and delayed gastric emptying. Methods: We retrospectively evaluated all patients who were maintained on CAPD for a minimum of 90 days in Sudan, in the period between May 2005 and Apr 2010. We examined the incidence of various non-infectious complications and their possible associations. Results: The analysis included 296 patients including 71 children (24%). Males constituted 62.2% of the study population and 13.9% were diabetic. The incidence per 100 patient-years of various non-infectious complications was as follows: hypokalemia (30.4), catheter dysfunction (10.8), dialysate leak (5.3), hernia (4.7), hemorrhagic effluent (4.7), inflow pain (2.3), upper gastrointestinal symptoms (2) and cuff extrusion (0.9). Catheter block and hernia were diagnosed with a median duration after catheter insertion of 6 and 7.5 months, respectively. Catheter block was significantly more prevalent among children (22.5% versus 9.3%; P = 0.006). A high body mass index (BMI) was the only identified independent predictor for leak (OR 1.4, P = 0.005). More than half of the 16 hernias were umbilical, and four of the five inguinal hernias were bilateral. Non-infectious complications were responsible for 32% of technique failures. Conclusion: Non-infectious complications were fairly common among our CAPD patients and led to catheter removal in a considerable number of patients. Care is, therefore, needed to screen CAPD patients for these complications in order to timely address and manage problems. Keywords: Peritoneal Dialysis; Non-infectious Complications; Sudan; Herni