Critical Points for Elliptic Equations with Prescribed Boundary Conditions

This paper concerns the existence of critical points for solutions to second order elliptic equations of the form $\nabla\cdot \sigma(x)\nabla u=0$ posed on a bounded domain $X$ with prescribed boundary conditions. In spatial dimension $n=2$, it is known that the number of critical points (where $\nabla u=0$) is related to the number of oscillations of the boundary condition independently of the (positive) coefficient $\sigma$. We show that the situation is different in dimension $n\geq3$. More precisely, we obtain that for any fixed (Dirichlet or Neumann) boundary condition for $u$ on $\partial X$, there exists an open set of smooth coefficients $\sigma(x)$ such that $\nabla u$ vanishes at least at one point in $X$. By using estimates related to the Laplacian with mixed boundary conditions, the result is first obtained for a piecewise constant conductivity with infinite contrast, a problem of independent interest. A second step shows that the topology of the vector field $\nabla u$ on a subdomain is not modified for appropriate bounded, sufficiently high-contrast, smooth coefficients $\sigma(x)$. These results find applications in the class of hybrid inverse problems, where optimal stability estimates for parameter reconstruction are obtained in the absence of critical points. Our results show that for any (finite number of) prescribed boundary conditions, there are coefficients $\sigma(x)$ for which the stability of the reconstructions will inevitably degrade.Comment: 26 pages, 4 figure

The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis

The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids, cholesterol and acetylcholine, and the acetylation of proteins and histones. We had previously reported that, although loss of Drosophila ATPCL reduced levels of Acetyl-CoA, unlike its human counterpart, it does not affect global histone acetylation and gene expression, suggesting that its role in histone acetylation is either partially redundant in Drosophila or compensated by alternative pathways. Here, we describe that depletion of DmATPCL affects spindle organization, cytokinesis, and fusome assembly during male meiosis, revealing an unanticipated role for DmATPCL during spermatogenesis. We also show that DmATPCL mutant meiotic phenotype is in part caused by a reduction of fatty acids, but not of triglycerides or cholesterol, indicating that DmATPCL-derived Acetyl-CoA is predominantly devoted to the biosynthesis of fatty acids during spermatogenesis. Collectively, our results unveil for the first time an involvement for DmATPCL in the regulation of meiotic cell division, which is likely conserved in human cells

Finding Your Literature Match -- A Recommender System

The universe of potentially interesting, searchable literature is expanding continuously. Besides the normal expansion, there is an additional influx of literature because of interdisciplinary boundaries becoming more and more diffuse. Hence, the need for accurate, efficient and intelligent search tools is bigger than ever. Even with a sophisticated search engine, looking for information can still result in overwhelming results. An overload of information has the intrinsic danger of scaring visitors away, and any organization, for-profit or not-for-profit, in the business of providing scholarly information wants to capture and keep the attention of its target audience. Publishers and search engine engineers alike will benefit from a service that is able to provide visitors with recommendations that closely meet their interests. Providing visitors with special deals, new options and highlights may be interesting to a certain degree, but what makes more sense (especially from a commercial point of view) than to let visitors do most of the work by the mere action of making choices? Hiring psychics is not an option, so a technological solution is needed to recommend items that a visitor is likely to be looking for. In this presentation we will introduce such a solution and argue that it is practically feasible to incorporate this approach into a useful addition to any information retrieval system with enough usage.Comment: Contribution to the proceedings of the colloquium Future Professional Communication in Astronomy II, 13-14 April 2010, Cambridge, Massachusetts. 11 pages, 4 figures

Trend in primary caesarean delivery. A five-year experience in Abruzzo, Italy

Background: Primary caesarean section (PCS) rate is one of the main indicators of quality of care suggested by the Italian Government. Hospital rankings are usually based on it, therefore lower rates reflect more appropriate clinical practice. The aim of this study is to describe a five-year trend of PCS rate in Abruzzo region from 2009 to 2013 and to examine the medical indications for this mode of delivery. Methods: Forty-five thousand one hundred forty-nine deliveries occurring from 2009 to 2013 were collected from all hospital discharge records (HDR) and analyzed. Among them we found 12,542 PCS. Odds ratios (ORs) with 95% confidence interval (95% CI) were estimated using logistic regression methods to evaluate the relationship between maternal risk factors and PCS in hospital over 1000 delivery/yrs. Results: The five-year PCS rate was 28.9%, with a decreasing trend from 31.4% in 2009 to 26.1% in 2013. Vasto Civil Hospital shows the lowest PCS rate (17.9% in 2013) among hospitals with a maximum of 1000 deliveries per year, while Pescara Civil Hospital shows the lowest PCS rate (25.4% in 2013) among hospitals with over 1000 deliveries per year. Women with major risk factors for cesarean section delivered more frequently in maternity units over 1000 delivery/yrs. Logistic regression analyses showed as diabetes, hypertension, twin pregnancy, fetal distress and preterm delivery were significant risk factors to deliver in unit over 1000 delivery/yrs. The most frequent (overall 66.6%) discharge diagnosis recorded in Hospital discharge records (HDR) is "Caesarean Delivery Without Indication". 7.3% of PCS made in Abruzzo concerns women living in other Italian regions. 11.4% of PCS contains one of the indications to caesarean section (CS) that the Italian Guidelines consider appropriate. Conclusions: During the analyzed period, Abruzzo showed a decreasing, but still too high, PCS rate, compared to the limits fixed by the Italian Ministry of Health. Considering the limitation of this study, based on administrative data that are poor in clinical information, it is not possible to define the appropriateness of all caesarean sections

Laboratory Test Campaign Aimed at the Analysis of an Uncommon Wear Phenomenon in a Marble Quarry

The use of ornamental stones has a historical value that makes them strategically precious in Italy; marble can offer high performance in architectural applications, even though the variability of the rock mass requires detailed studies to optimize the exploitation techniques and reduce waste. Italy is world famous for its marble, which is extracted mainly through chainsaw cutting machines, which are currently used intensively due to their high‐safety working conditions compared to alternative techniques and for their great versatility, especially in underground applications. Although this cutting technique is well‐rooted, an uncommon problem of tool wear was found in the quarry under study, which strongly affected productivity. A series of laboratory test were carried out to estimate the wear potential of the rock and the suitability of the tools. The Cerchar abrasivity test highlighted a mean wear potential for the marble of 2.77, while microhardness outcomes pointed out the presence of quartz veins in the tested material (values over 10000 MPa). Finally, additives typically used in the conditioning process of EPB machines in tunneling were tested with the purpose of reducing the extent of wear. A reduction of about 50% in the wear (in terms of weight lost) was obtained for a moisture content of 9%

Comparative planning and housing studies beyond taxonomy: a genealogy of the special programme for rehousing (Portugal)

Recent European comparative studies in the fields of housing policy and spatial planning have been dominated by taxonomical and linear approaches, and by normative calls for convergence toward systems considered more ‘mature’ or ‘advanced’. In this article, we adopt a genealogical perspective and consider those cultures that are central to the shaping of policy. We set out a long-term exploration of the intersection between spatial planning and housing policy in Portugal and focus on the Special Programme for Rehousing (Programa Especial de Realojamento, PER), a programme that has had changing roles (from a financial instrument to a core component of policies of urban regeneration) in connection with political and planning cultures changing in time and space. In this way, we provide evidence of the limited capacity of taxonomic and linear approaches to describe planning and housing systems undergoing processes of change and, conversely, show the potential of genealogical research.info:eu-repo/semantics/publishedVersio

Re-discovery of the top quark at the LHC and first measurements

This paper describes the top quark physics measurements that can be performed with the first LHC data in the ATLAS and CMS experiments.Comment: 6 pages, 2 figures. Talk given at `V Workshop Italiano sulla Fisica pp a LHC', Perugia, Italy, 30 January - 2 February 200