A model based framework for air quality indices and population risk evaluation, with an application to the analysis of Scottish air quality data

The paper is devoted to the development of a statistical framework for air quality assessment at the country level and for the evaluation of the ambient population exposure and risk with respect to airborne pollutants. The framework is based on a multivariate space–time model and on aggregated indices defined at different levels of aggregation in space and time. The indices are evaluated, uncertainty included, by considering both the model outputs and the information on the population spatial distribution. The framework is applied to the analysis of air quality data for Scotland for 2009 referring to European and Scottish air quality legislation

On the robustness of acoustic black hole spectra

We study the robustness of the spectrum emitted by an acoustic black hole by considering series of stationary flows that become either subsonic or supersonic, i.e. when the horizon disappears. We work with the superluminal Bogoliubov dispersion of Bose--Einstein condensates. We find that the spectrum remains remarkably Planckian until the horizon disappears. When the flow is everywhere supersonic, new pair creation channels open. This will be the subject of a forthcoming work.Comment: 4 pages, 2 figure, jpconf.cls; to appear in the proceedings of the Spanish Relativity Meeting ERE201

Instability of the superfluid flow as black-hole lasing effect

We show that the instability leading to the decay of the one-dimensional superfluid flow through a penetrable barrier are due to the black-hole lasing effect. This dynamical instability is triggered by modes resonating in an effective cavity formed by two horizons enclosing the barrier. The location of the horizons is set by $v(x)=c(x)$, with $v(x),c(x)$ being the local fluid velocity and sound speed, respectively. We compute the critical velocity analytically and show that it is univocally determined by the horizons configuration. In the limit of broad barriers, the continuous spectrum at the origin of the Hawking-like radiation and of the Landau energetic instability is recovered.Comment: 18 pages, 3 figure

Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms.

Perturbation of iron distribution is observed in many neurodegenerative disorders, including Alzheimer's and Parkinson's disease, but the comprehension of the metal role in the development and progression of such disorders is still very limited. The combination of more powerful brain imaging techniques and faster genomic DNA sequencing procedures has allowed the description of a set of genetic disorders characterized by a constant and often early accumulation of iron in specific brain regions and the identification of the associated genes; these disorders are now collectively included in the category of neurodegeneration with brain iron accumulation (NBIA). So far 10 different genetic forms have been described but this number is likely to increase in short time. Two forms are linked to mutations in genes directly involved in iron metabolism: neuroferritinopathy, associated to mutations in the FTL gene and aceruloplasminemia, where the ceruloplasmin gene product is defective. In the other forms the connection with iron metabolism is not evident at all and the genetic data let infer the involvement of other pathways: Pank2, Pla2G6, C19orf12, COASY, and FA2H genes seem to be related to lipid metabolism and to mitochondria functioning, WDR45 and ATP13A2 genes are implicated in lysosomal and autophagosome activity, while the C2orf37 gene encodes a nucleolar protein of unknown function. There is much hope in the scientific community that the study of the NBIA forms may provide important insight as to the link between brain iron metabolism and neurodegenerative mechanisms and eventually pave the way for new therapeutic avenues also for the more common neurodegenerative disorders. In this work, we will review the most recent findings in the molecular mechanisms underlining the most common forms of NBIA and analyze their possible link with brain iron metabolism

Black hole lasers in Bose-Einstein condensates

We consider elongated condensates that cross twice the speed of sound. In the absence of periodic boundary conditions, the phonon spectrum possesses a discrete and finite set of complex frequency modes that induce a laser effect. This effect constitutes a dynamical instability and is due to the fact that the supersonic region acts as a resonant cavity. We numerically compute the complex frequencies and density-density correlation function. We obtain patterns with very specific signatures. In terms of the gravitational analogy, the flows we consider correspond to a pair of black hole and white hole horizons, and the laser effect can be conceived as a self-amplified Hawking radiation. This is verified by comparing the outgoing flux at early time with the standard black hole radiation.Comment: iopams, 37 pages, 14 figures, 1 table; for associated gif animations, see http://people.sissa.it/~finazzi/bec_bhlasers/movies/ or http://iopscience.iop.org/1367-2630/12/9/095015/media. Published on New. J. Phys. (http://iopscience.iop.org/1367-2630/12/9/095015/). V2: few new comments, modified figure

Recent finding and new technologies in nephrolithiasis: a review of the recent literature

This review summarizes recent literature on advances regarding renal and ureteral calculi, with particular focus in areas of recent advances in the overall field of urolithiasis. Clinical management in everyday practice requires a complete understanding of the issues regarding metabolic evaluation and subgrouping of stone-forming patients, diagnostic procedures, effective treatment regime in acute stone colic, medical expulsive therapy, and active stone removal. In this review we focus on new perspectives in managing nephrolitihiasis and discuss recentadvances, including medical expulsive therapy, new technologies, and refinements of classical therapy such as shock wave lithotripsy, give a fundamental modification of nephrolithiasis management. Overall, this field appears to be the most promising, capable of new developments in ureterorenoscopy and percutaneous approaches. Further improvements are expected from robotic-assisted procedures, such as flexible robotics in ureterorenoscopy

Modification of magnetic and transport properties of manganite layers in Au/La_0.67Sr_0.33MnO_3/SrTiO_3 interfaces

The effect of gold capping on magnetic and transport properties of optimally doped manganite thin films is studied. An extraordinary suppression of conductivity and magnetic properties occurs in epitaxial (001) La_0.67Sr_0.33MnO_3 (LSMO) films grown on SrTiO_3 upon deposition of 2 nm of Au: in the case of ultrathin films of LSMO (4 nm thick) the resistivity increases by four orders of magnitude while the Curie temperature decreases by 180 K. Zero-field 55Mn nuclear magnetic resonance reveals a significant reduction of ferromagnetic double-exchange mechanism in manganite films upon the gold capping. We find evidence for the formation of a 1.9-nm thick magnetic "dead-layer" at the Au/LSMO interface, associated with the creation of interfacial non double-exchange insulating phases.Comment: 4 figure