46,880 research outputs found
Longitudinal detection of radiological abnormalities with time-modulated LSTM
Convolutional neural networks (CNNs) have been successfully employed in
recent years for the detection of radiological abnormalities in medical images
such as plain x-rays. To date, most studies use CNNs on individual examinations
in isolation and discard previously available clinical information. In this
study we set out to explore whether Long-Short-Term-Memory networks (LSTMs) can
be used to improve classification performance when modelling the entire
sequence of radiographs that may be available for a given patient, including
their reports. A limitation of traditional LSTMs, though, is that they
implicitly assume equally-spaced observations, whereas the radiological exams
are event-based, and therefore irregularly sampled. Using both a simulated
dataset and a large-scale chest x-ray dataset, we demonstrate that a simple
modification of the LSTM architecture, which explicitly takes into account the
time lag between consecutive observations, can boost classification
performance. Our empirical results demonstrate improved detection of commonly
reported abnormalities on chest x-rays such as cardiomegaly, consolidation,
pleural effusion and hiatus hernia.Comment: Submitted to 4th MICCAI Workshop on Deep Learning in Medical Imaging
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Spatiotemporal variation of methane and other trace hydrocarbon concentrations in the valley of Mexico
Mexico City is the world's largest and most polluted urban center. We examine the distribution of methane and other hydrocarbons within the Valley of Mexico, using it as a model for the role developing megacities will play in the next century of geochemical cycling. Seventy-five whole air samples were analyzed with multivariate statistical techniques, including factor analysis using principal components. Methane concentrations are highly variable in space and time, due to air circulations and source distribution. Landfills and open sewage canals are major inputs. Emissions into and out from the valley are modeled to be ∼515 t per day. Per capita emission is 0.01 t per annum per person, consistent with the global average for human related anaerobic generation. Natural gas leaks are small, and likely to be higher in other developing megacities; Mexican natural gas use has been discouraged out of earthquake safety concerns. In contrast, liquefied petroleum gas loss constitutes the major emission of propane and butane estimated at a leak rate of 5-10%. Kyoto and other environmental conventions have ignored methane as a greenhouse gas. Our analysis underscores the need to consider methane and other hydrocarbons, and the urbanization process, in future emission protocols. © 2002 Elsevier Science Ltd. All rights reserved
Spherical Functions Associated With the Three Dimensional Sphere
In this paper, we determine all irreducible spherical functions \Phi of any K
-type associated to the pair (G,K)=(\SO(4),\SO(3)). This is accomplished by
associating to \Phi a vector valued function H=H(u) of a real variable u, which
is analytic at u=0 and whose components are solutions of two coupled systems of
ordinary differential equations. By an appropriate conjugation involving Hahn
polynomials we uncouple one of the systems. Then this is taken to an uncoupled
system of hypergeometric equations, leading to a vector valued solution P=P(u)
whose entries are Gegenbauer's polynomials. Afterward, we identify those
simultaneous solutions and use the representation theory of \SO(4) to
characterize all irreducible spherical functions. The functions P=P(u)
corresponding to the irreducible spherical functions of a fixed K-type \pi_\ell
are appropriately packaged into a sequence of matrix valued polynomials
(P_w)_{w\ge0} of size (\ell+1)\times(\ell+1). Finally we proved that \widetilde
P_w={P_0}^{-1}P_w is a sequence of matrix orthogonal polynomials with respect
to a weight matrix W. Moreover we showed that W admits a second order symmetric
hypergeometric operator \widetilde D and a first order symmetric differential
operator \widetilde E.Comment: 49 pages, 2 figure
Superspace Formulation in a Three-Algebra Approach to D=3, N=4,5 Superconformal Chern-Simons Matter Theories
We present a superspace formulation of the D=3, N=4,5 superconformal
Chern-Simons Matter theories, with matter supermultiplets valued in a
symplectic 3-algebra. We first construct an N=1 superconformal action, and then
generalize a method used by Gaitto and Witten to enhance the supersymmetry from
N=1 to N=5. By decomposing the N=5 supermultiplets and the symplectic 3-algebra
properly and proposing a new super-potential term, we construct the N=4
superconformal Chern-Simons matter theories in terms of two sets of generators
of a (quaternion) symplectic 3-algebra. The N=4 theories can also be derived by
requiring that the supersymmetry transformations are closed on-shell. The
relationship between the 3-algebras, Lie superalgebras, Lie algebras and
embedding tensors (proposed in [E. A. Bergshoeff, O. Hohm, D. Roest, H.
Samtleben, and E. Sezgin, J. High Energy Phys. 09 (2008) 101.]) is also
clarified. The general N=4,5 superconformal Chern-Simons matter theories in
terms of ordinary Lie algebras can be rederived in our 3-algebra approach. All
known N=4,5 superconformal Chern-Simons matter theories can be recovered in the
present superspace formulation for super-Lie-algebra realization of symplectic
3-algebras.Comment: 37 pages, minor changes, published in PR
Finite time decoherence could be suppressed efficiently in photonic crystal
The decoherence of two initially entangled qubits in anisotropic band gap
photonic crystal has been studied analytically without Born or Markovian
approximation. It is shown that the decoherence dynamics of two qubits in
photonic crystal is greatly different from that of two qubits in vacuum or
subjected to usual non-Markovian reservoir. The results also show that the
finite time decoherence invoked by spontaneous emission could be suppressed
efficiently and the entanglement of the Bell state possesses odd parity is more
easily preserved in photonic crystal than that of the Bell state possesses even
parity under the same condition. A store scheme for entangled particle pair is
proposed.Comment: 4 pages, 7 figure
Quantum interference in deformed carbon nanotube waveguides
Quantum interference (QI) in two types of deformed carbon nanotubes (CNTs),
i.e., axially stretched and AFM tip-deformed CNTs, has been investigated by the
pi-electron only and four-orbital tight-binding (TB) method. It is found that
the rapid conductance oscillation (RCO) period is very sensitive to the applied
strains, and decreases in an inverse proportion to the deformation degree,
which could be used as a powerful experimental tool to detect precisely the
deformation degree of the deformed CNTs. Also, the sigma-pi coupling effect is
found to be negligible under axially stretched strain, while it works on the
transport properties of the tip-deformed CNTs.Comment: 14 pages and 5 figure
Thermalized Displaced Squeezed Thermal States
In the coordinate representation of thermofield dynamics, we investigate the
thermalized displaced squeezed thermal state which involves two temperatures
successively. We give the wavefunction and the matrix element of the density
operator at any time, and accordingly calculate some quantities related to the
position, momentum and particle number operator, special cases of which are
consistent with the results in the literature. The two temperatures have
diffenent correlations with the squeeze and coherence components. Moreover,
different from the properties of the position and momentum, the average value
and variance of the particle number operator as well as the second-order
correlation function are time-independent.Comment: 7 pages, no figures, Revtex fil
RNomics: a computational search for box C/D snoRNA genes in the D. melanogaster genome.
Motivation: In eukaryotes, the family of non-coding RNA
genes includes a number of genes encoding small nucleolar
RNAs (mainly C/D and H/ACA snoRNAs), which act as
guides in the maturation or post-transcriptional modifications
of target RNA molecules. Since in Drosophila melanogaster
(Dm) only few examples of snoRNAs have been identified so
far by cDNA libraries screening, integration of the molecular
data with in silico identification of these types of genes could
throw light on their organization in the Dm genome.
Results: We have performed a computational screening of
the Dm genome for C/D snoRNA genes, followed by experimental validation of the putative candidates. Few of the
26 confirmed snoRNAs had been recognized by cDNA library
analysis. Organization of the Dm genome was also
found to be more variegated than previously suspected, with
snoRNA genes nested in both the introns and exons of
protein-coding genes. This finding suggests that the presence
of additional mechanisms of snoRNA biogenesis based
on the alternative production of overlapping mRNA/snoRNA
molecules.
Availability: Additional information is available at http://www.
bioinformatica.unito.it/bioinformatics/snoRNA
A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property.
Surface display of proteins by sortases in Gram-positive bacteria is crucial for bacterial fitness and virulence. We found a unique gene locus encoding an amylase-binding adhesin AbpA and a sortase B in oral streptococci. AbpA possesses a new distinct C-terminal cell wall sorting signal. We demonstrated that this C-terminal motif is required for anchoring AbpA to cell wall. In vitro and in vivo studies revealed that SrtB has dual functions, anchoring AbpA to the cell wall and processing AbpA into a ladder profile. Solution structure of AbpA determined by NMR reveals a novel structure comprising a small globular α/β domain and an extended coiled-coil heliacal domain. Structural and biochemical studies identified key residues that are crucial for amylase binding. Taken together, our studies document a unique sortase/adhesion substrate system in streptococci adapted to the oral environment rich in salivary amylase
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