Proper Motions, Orbits, and Tidal Influences of Milky Way Dwarf Spheroidal Galaxies

We combine Gaia EDR3 astrometry with accurate photometry and utilize a probabilistic mixture model to measure the systemic proper motion of 52 dwarf spheroidal (dSph) satellite galaxies of the Milky Way (MW). For the 46 dSphs with literature line-of-sight velocities we compute orbits in both a MW and a combined MW + Large Magellanic Cloud (LMC) potential and identify Car II, Car III, Hor I, Hyi I, Phx II, and Ret II as likely LMC satellites. 40% of our dSph sample has a >25% change in pericenter and/or apocenter with the MW + LMC potential. For these orbits, we Monte Carlo sample over the observational uncertainties for each dSph and the uncertainties in the MW and LMC potentials. We predict that Ant II, Boo III, Cra II, Gru II, and Tuc III should be be tidally disrupting by comparing each dSph's average density relative to the MW density at its pericenter. dSphs with large ellipticity (CVn I, Her, Tuc V, UMa I, UMa II, UMi, Wil 1) show a preference for their orbital direction to align with their major axis even for dSphs with large pericenters. We compare the dSph radial orbital phase to subhalos in MW-like N-body simulations and infer that there is not an excess of satellites near their pericenter. With projections of future Gaia data releases, we find dSph orbital precision will be limited by uncertainties in the distance and/or MW potential rather than proper motion precision. Finally, we provide our membership catalogs to enable community follow-up.Comment: 26 pages, 13 figures + appendix with extra figures. ApJ accepted. Catalogs with membership, additional figures, and a machine readable compilation of tables 1-4 are available at https://zenodo.org/record/653329

Computational Investigation of Structure-Function Relationship in Fluorine-Functionalized MOFs for PFOA Capture from Water

A strategy that can be used to develop metal-organic frameworks (MOFs) to capture per- and poly-fluoroalkyl substances (PFAS) from water is functionalizing them with fluorine moieties. We investigated different fluorine-functionalization strategies and their performance in removing PFAS from water using molecular simulations. Perfluorooctanoic acid (PFOA), one of the most widely encountered PFAS in water sources, was used as the probe molecule. Our simulations show that fluorine functionalization by incorporating fluorinated anions as bridging ligands in MOFs creates additional binding sites for PFOA; however, the same sites also attract water molecules, which casts doubt on their potential use. In contrast, trifluoromethyl or fluorine substitution of the MOF ligands results in higher hydrophobicity. However, the pores fluorinated with this method should have the optimum size to accommodate PFOA. Likewise, post-synthetic fluorine functionalization of MOFs through grafting of perfluorinated alkanes showed increased PFOA affinity. Fluorine-functionalized MOFs with high hydrophobicity and optimized pore sizes can effectively capture PFOA from water at very low concentrations of PFOA

Slow release and delivery of antisense oligonucleotide drug by self-assembled peptide amphiphile nanofibers

Cataloged from PDF version of article.Antisense oligonucleotides provide a promising therapeutic approach for several disorders including cancer. Chemical stability, controlled release, and intracellular delivery are crucial factors determining their efficacy. Gels composed of nanofibrous peptide network have been previously suggested as carriers for controlled delivery of drugs to improve stability and to provide controlled release, but have not been used for oligonucleotide delivery. In this work, a self-assembled peptide nanofibrous system is formed by mixing a cationic peptide amphiphile (PA) with Bcl-2 antisense oligodeoxynucleotide (ODN), G3139, through electrostatic interactions. The self-assembly of PA-ODN gel was characterized by circular dichroism, rheology, atomic force microscopy (AFM) and scanning electron microscopy (SEM). AFM and SEM images revealed establishment of the nanofibrous PA-ODN network. Due to the electrostatic interactions between PA and ODN, ODN release can be controlled by changing PA and ODN concentrations in the PA-ODN gel. Cellular delivery of the ODN by PA-ODN nanofiber complex was observed by using fluorescently labeled ODN molecule. Cells incubated with PA-ODN complex had enhanced cellular uptake compared to cells incubated with naked ODN. Furthermore, Bcl-2 mRNA amounts were lower in MCF-7 human breast cancer cells in the presence of PA-ODN complex compared to naked ODN and mismatch ODN evidenced by quantitative RT-PCR studies. These results suggest that PA molecules can control ODN release, enhance cellular uptake and present a novel efficient approach for gene therapy studies and oligonucleotide based drug deliver

Template-Directed Synthesis of Silica Nanotubes for Explosive Detection

Cataloged from PDF version of article.Fluorescent porous organic-inorganic thin films are of interest of explosive detection because of their vapor phase fluorescence quenching property. In this work, we synthesized fluorescent silica nanotubes using a biomineralization process through self-assembled peptidic nanostructures. We designed and synthesized an amyloid-like peptide self-assembling into nanofibers to be used as a template for silica nanotube formation. The amine groups on the peptide nanofibrous system were used for nucleation of silica nanostructures. Silica nanotubes were used to prepare highly porous surfaces, and they were doped with a fluorescent dye by physical adsorption for explosive sensing. These porous surfaces exhibited fast, sensitive, and highly selective fluorescence quenching against nitro-explosive vapors. The materials developed in this work have vast potential in sensing applications due to enhanced surface area. © 2011 American Chemical Society

Self-Assembled Peptide Nanofiber Templated One-Dimensional Gold Nanostructures Exhibiting Resistive Switching

Cataloged from PDF version of article.An amyloid-like peptide molecule self-assembling into one-dimensional nanofiber structure in ethanol was designed and synthesized with functional groups that can bind to gold ions. The peptide nanofibers were used as templates for nucleation and growth of one-dimensional gold nanostructures in the presence of ascorbic acid as reducing agent. We performed multistep seed-mediated synthesis of gold nanoparticles by changing peptide/gold precursor and peptide/reducing agent ratios. Gold nanostructures with a wide range of morphologies such as smooth nanowires, noodle-like one-dimensional nanostructures, and uniform aggregates of spherical nanoparticles were synthesized by use of an environmentally friendly synthesis method. Nanoscale electrical properties of gold-peptide nanofibers were investigated using atomic force microscopy. Bias dependent current (IV) measurements on thin films of gold-peptide nanofiber hybrid revealed tunneling dominated transport and resistive switching. Gold-peptide nanofiber composite nanostructures can provide insight into electrical conduction in biomolecular/inorganic composites, highlighting their potential applications in electronics and optics. © 2012 American Chemical Society

December (2013) Res

Abstract In vitro plant regeneration and daughter corm formation of saffron (Crocus sativus L.

The Magellanic Edges Survey II. Formation of the LMC's northern arm

The highly-substructured outskirts of the Magellanic Clouds provide ideal locations for studying the complex interaction history between both Clouds and the Milky Way (MW). In this paper, we investigate the origin of a >20$^\circ$ long arm-like feature in the northern outskirts of the Large Magellanic Cloud (LMC) using data from the Magellanic Edges Survey (MagES) and Gaia EDR3. We find that the arm has a similar geometry and metallicity to the nearby outer LMC disk, indicating that it is comprised of perturbed disk material. Whilst the azimuthal velocity and velocity dispersions along the arm are consistent with those in the outer LMC, the in-plane radial velocity and out-of-plane vertical velocity are significantly perturbed from equilibrium disk kinematics. We compare these observations to a new suite of dynamical models of the Magellanic/MW system, which describe the LMC as a collection of tracer particles within a rigid potential, and the SMC as a rigid Hernquist potential. Our models indicate the tidal force of the MW during the LMC's infall is likely responsible for the observed increasing out-of-plane velocity along the arm. Our models also suggest close LMC/SMC interactions within the past Gyr, particularly the SMC's pericentric passage ~150 Myr ago and a possible SMC crossing of the LMC disk plane ~400 Myr ago, likely do not perturb stars that today comprise the arm. Historical interactions with the SMC prior to ~1 Gyr ago may be required to explain some of the observed kinematic properties of the arm, in particular its strongly negative in-plane radial velocity.Comment: Accepted by MNRA

The Magellanic Edges Survey III. Kinematics of the disturbed LMC outskirts

We explore the structural and kinematic properties of the outskirts of the Large Magellanic Cloud (LMC) using data from the Magellanic Edges Survey (MagES) and Gaia EDR3. Even at large galactocentric radii ($8^\circ<R<11^\circ$), we find the north-eastern LMC disk is relatively unperturbed: its kinematics are consistent with a disk of inclination ~$36.5^\circ$ and line-of-nodes position angle ~$145^\circ$ east of north. In contrast, fields at similar radii in the southern and western disk are significantly perturbed from equilibrium, with non-zero radial and vertical velocities, and distances significantly in front of the disk plane implied by our north-eastern fields. We compare our observations to simple dynamical models of the Magellanic/Milky Way system which describe the LMC as a collection of tracer particles within a rigid potential, and the Small Magellanic Cloud (SMC) as a rigid Hernquist potential. A possible SMC crossing of the LMC disk plane ~400 Myr ago, in combination with the LMC's infall to the Milky Way potential, can qualitatively explain many of the perturbations in the outer disk. Additionally, we find the claw-like and arm-like structures south of the LMC have similar metallicities to the outer LMC disk ([Fe/H]~-1), and are likely comprised of perturbed LMC disk material. The claw-like substructure is particularly disturbed, with out-of-plane velocities >60 km s$^{-1}$ and apparent counter-rotation relative to the LMC's disk motion. More detailed N-body models are necessary to elucidate the origin of these southern features, potentially requiring repeated interactions with the SMC prior to ~1 Gyr ago.Comment: Accepted by MNRA