A rapid method for optimization of the rocket propulsion system for single-stage-to-orbit vehicles

A rapid analytical method for the optimization of rocket propulsion systems is presented for a vertical take-off, horizontal landing, single-stage-to-orbit launch vehicle. This method utilizes trade-offs between propulsion characteristics affecting flight performance and engine system mass. The performance results from a point-mass trajectory optimization program are combined with a linearized sizing program to establish vehicle sizing trends caused by propulsion system variations. The linearized sizing technique was developed for the class of vehicle systems studied herein. The specific examples treated are the optimization of nozzle expansion ratio and lift-off thrust-to-weight ratio to achieve either minimum gross mass or minimum dry mass. Assumed propulsion system characteristics are high chamber pressure, liquid oxygen and liquid hydrogen propellants, conventional bell nozzles, and the same fixed nozzle expansion ratio for all engines on a vehicle

CSI technology validation on an LSS ground experiment facility

The test bed developed at JPL for experimental evaluation of new technologies for the control of large flexible space structures is described. The experiment consists of a flexible spacecraft dynamic simulator, sensors, actuators, a microcomputer, and an advanced programming environment. The test bed has been operational for over a year, and thus far nine experiments were completed or are currently in progress. Several of these experiments were reported at the 1987 CSI conference, and several recent ones are documented in this paper, including high order adaptive control, non-parametric system identification, and mu-synthesis robust control. An aggressive program of experiments is planned for the forseeable future

New mode tracking methods in aeroelastic analysis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77312/1/AIAA-12552-803.pd

Improvement of normalization methods for eigenvector derivatives

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76868/1/AIAA-11108-459.pd

The impact of COVID‐19 in Dravet syndrome: A UK survey

OBJECTIVES: To understand the risks, impact and outcome of COVID-19 in people affected by Dravet Syndrome (DS). MATERIALS AND METHODS: An anonymous cross-sectional online survey was conducted between June 17 and July 13, 2020, addressed to families of people with DS. RESULTS: A total of 116 responses were collected, from families of children (n = 86; 74%) and adults (30; 26%) with DS. The majority (106; 91%) were shielded at the family home during lockdown. Symptoms compatible with COVID-19 were reported in 22 (19%) individuals. Only four individuals with symptoms had a PCR swab test, none of which was positive. Only one symptomatic person had antibody testing (but not swab testing), which was positive. One person had repeatedly positive swab tests whilst in hospital for renal failure, but had no typical symptoms of COVID-19. In 50% of people with DS who developed possible or probable COVID-19 symptoms, seizure worsening was reported, in terms of increased seizure frequency or duration or both. Medical attention was required in 9/22 (41%), all of whom were children. CONCLUSIONS: In this cohort of people with DS, we observed an infection rate, determined by compatible symptoms, of 19%, with no deaths and benign outcome in most cases despite the underlying complex epilepsy although children often required medical attention. Early adoption of preventative measures, including testing of symptomatic individuals, regular surveillance for people living in residential care facilities, and shielding of individuals with comorbidities increasing the risk of severe outcome, may limit the impact of COVID-19

Only a Smile / music by J.S. Zamesnik; words by Eldred Edson

Key of G. Cover: a drawing of a woman\u27s portrait; Publisher: Sam Fox Pub. Co. (Cleveland)https://egrove.olemiss.edu/sharris_d/1028/thumbnail.jp

Increased neuronal nitric oxide synthase activity in retinal neurons in early diabetic retinopathy

PURPOSE. There are increased levels of nitric oxide (NO) in diabetic retinas. The purpose of this study was to determine the extent that neuronal nitric oxide synthase (nNOS) contributes to the increased levels of retinal NO in early diabetic retinopathy by examining the expression and activity of nNOS in retinal neurons after 5 weeks of diabetes. METHODS. Changes in NO levels were measured using NO imaging of retinal neurons in mice with streptozotocin-induced diabetes for five weeks. NO imaging was compared to nNOS localization using immunocytochemistry, and nNOS message and protein levels were measured using quantitative real-time PCR and western blots. RESULTS. There was a close anatomic correlation between the localization of the increased NO production and the nNOS immunoreactivity in the retinal plexiform layers of diabetic retinas. There was no change in nNOS message, but nNOS protein was decreased and its subcellular localization was altered. Treatment with insulin or aminoguanidine partially ameliorated the increase in NO in diabetic retinas. CONCLUSIONS. These results suggest that increased nNOS activity is responsible for the majority of increased NO in retinal neurons in early diabetic retinopathy. This supports a role for increased nNOS activity in the early neuronal dysfunction in the diabetic retina.National Institutes of Health (NEI EY04785 to WDE