Growth performances and hematological characterisation of rainbow trout (Oncorhynchus mykiss Walbaum, 1792)

In present study correlations between hematologic characteristics and growth performances of rainbow trout were investigated. Fish were provided from a raceway trout farm located in the valley of the river Jerka near the city of Novi Pazar (N:43°13’67’’; E:20°43’96’’). The farm consists of 8 concrete lined production ponds (22 x 3 m x 1,2 m each) in which water is exchanged 75 times per day. After stocking fish from production ponds are being monthly classified into two groups depending on their body mass and body length and larger fish are transferred in separate ponds. For this study one year old fish were sampled. 25 from slower and 25 from faster growing group. Analyses were performed in 4 consecutive days in accordance with animal welfare regulations (Official Gazette of the Republic of Serbia 41/2009). Fish growth performances were estimated from body mass, total and standard body length and Fulton condition factor. Hematological characterization of rainbow was established on the basis of Red Blood Cell (RBC) and White Blood Cell (WBC) count, hemoglobin concentration, Packed Cell Volume (PCV), Mean Corpuscular Volume of erythrocytes (MCV), Mean Corpuscular Hemoglobin in individual erythrocyte (MCH) and Mean Corpuscular Hemoglobin Concentration (MCHC) in a liter of erythrocytes. The results obtained were statistically analyzed by SPSS. It was found out that there exist significant correlation between hematological and growth characteristics. High linear regression coefficients can explain mass and length gain by hematological parameters

Evaluation of environmental conditions by fish hematology

In the work are shown basic principles of application of the haematological status in determination of physiological status of fishes, also a review of a number of research from this area is given. One part of the research includes analysis of parametres of hematological status of the individuals in their natural habitat, while the other part is focused on the research of these parametres in experimantal conditions based on changes of some of the factors. Review include erythrocyte line parameters (erythrocyte number, hemoglobin concentration, hematocrit, MCV, MCH and MCHC) in different conditions in species: Barbus balcanicus, Sqalius cephalus, Thymallus thymallus, Oncorhynchus mykiss, Carassius gibelio, Perca fluviatilis, Cyprinus carpio

Growth performances and hematological characterisation of rainbow trout (Oncorhynchus mykiss Walbaum, 1792)

In present study correlations between hematologic characteristics and growth performances of rainbow trout were investigated. Fish were provided from a raceway trout farm located in the valley of the river Jerka near the city of Novi Pazar (N:43°13’67’’; E:20°43’96’’). The farm consists of 8 concrete lined production ponds (22 x 3 m x 1,2 m each) in which water is exchanged 75 times per day. After stocking fish from production ponds are being monthly classified into two groups depending on their body mass and body length and larger fish are transferred in separate ponds. For this study one year old fish were sampled. 25 from slower and 25 from faster growing group. Analyses were performed in 4 consecutive days in accordance with animal welfare regulations (Official Gazette of the Republic of Serbia 41/2009). Fish growth performances were estimated from body mass, total and standard body length and Fulton condition factor. Hematological characterization of rainbow was established on the basis of Red Blood Cell (RBC) and White Blood Cell (WBC) count, hemoglobin concentration, Packed Cell Volume (PCV), Mean Corpuscular Volume of erythrocytes (MCV), Mean Corpuscular Hemoglobin in individual erythrocyte (MCH) and Mean Corpuscular Hemoglobin Concentration (MCHC) in a liter of erythrocytes. The results obtained were statistically analyzed by SPSS. It was found out that there exist significant correlation between hematological and growth characteristics. High linear regression coefficients can explain mass and length gain by hematological parameters

The EMA Assessment of Asciminib for the Treatment of Adult Patients With Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase Who Were Previously Treated With at Least Two Tyrosine Kinase Inhibitors

Asciminib is an allosteric high-affinity tyrosine kinase inhibitor (TKI) of the BCR-ABL1 protein kinase. This kinase is translated from the Philadelphia chromosome in chronic myeloid leukemia (CML). Marketing authorization for asciminib was granted on August 25, 2022 by the European Commission. The approved indication was for patients with Philadelphia chromosome-positive CML in the chronic phase which have previously been treated with at least 2 TKIs. Clinical efficacy and safety of asciminib were evaluated in the open-label, randomized, phase III ASCEMBL study. The primary endpoint of this trial was major molecular response (MMR) rate at 24 weeks. A significant difference in MRR rate was shown between the asciminib treated population and the bosutinib control group (25.5% vs. 13.2%, respectively, P=.029). In the asciminib cohort, adverse reactions of at least grade 3 with an incidence≥5% were thrombocytopenia, neutropenia, increased pancreatic enzymes, hypertension, and anemia. The aim of this article is to summarize the scientific review of the application which led to the positive opinion by the European Medicines Agency's Committee for Medicinal Products for Human Use.</p

Monitoring Standards Regulation Risk of Bans in Serbia

Risks are common to all aspects of banking. Therefore, not even neutral banking is risk proof. List of risks becomes longer as new instruments, new techniques and strategies, financial engineering, and new banking products, especially financial products, are introduced. This mainly refers to system risks and especially risk as a result of lack in banking management in dealing with unknown distant areas and markets and unknown instruments and techniques. Risk management is part of bank business policy, and can also be defined as bank’ s function of providing risk proof deals. In order to avoid risk, or at lest to lessen the risk to an acceptable level, it is necessary to analyze and manage risks. Risk analysis should underline key points and process of risk occurring. All bank resources can be exposed to risks, directly or indirectly, through liability towards a third party, market risks and other. The general goal of banking risk management is to create optimal relation between risks and income. This results in two basic of banking risk management. Firstly, avoiding being insolvent. Secondly, maximum increase in income rate on the amount with corrections according to risks

Monitoring Standards Regulation Risk of Banks in Serbia

Marketing decisions are often based upon measurements of the market place, which are usually constructed from sampled data. These data are obtained from mail surveys, face-to-face interviews, telephone surveys, interviews at shopping centers, etc. The recommended procedure is to capture data from a probability sampling scheme based on the assumption that the observations will be well balanced against all variables, independent of experimenter bias and necessary for valid inferences of unknown population parameters. The discussion in this paper compares the relevance of inferences from probabilistic samples to inferences from non-random samples, above all quota samples. It will be shown that inferences from quota samples could be more usefull than those from random samples and that quota samples are more informative in the presense of nonresponces