Transient conjugated heat transfer in thick walled pipes with uniform heat flux boundary condition

Paper presented at the 5th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, South Africa, 1-4 July, 2007.Transient conjugated heat transfer in thick walled pipes for thermally developing laminar flow is investigated involving two dimensional wall and axial fluid conduction. The problem is solved numerically by a finite difference method for hydrodynamically developed flow in a two regional pipe, initially isothermal in which the upstream region is insulated and the downstream region is subjected to a suddenly applied uniform heat flux. A parametric study is done to analyze the effects of four defining parameters namely, wall thickness ratio, wall-to-fluid thermal conductivity ratio, wall-to-fluid thermal diffusivity ratio and the Peclet number. The results are given by non-dimensional interfacial heat flux values, and it is observed that, heat transfer characteristics are strongly dependent on the parameter values.cs201

Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels

‘Compound A’ (4ı-(N-(4-acetamidobenzyl))-2,2-dimethyl-2,3-dihydro-5ıH-spiro[chromene-4,2ı-[1,4]oxazinan]-5ı-one) is a new spiro-cyclic benzopyran activator of the mitochondrial ATP-dependent potassium channels (mitoKATP). We researched the effect of compound A on ischemia/reperfusion (I/R)-induced ventricular arrhythmias. We also tested the hypothesis that the application of the activation of mitoKATP in combination with the inhibition of sarcolemmal ATP-dependent potassium channels (sarcKATP) may produce a stronger antiarrhythmic effect. In anesthetized rats, myocardial ischemia was performed by ligating the left main coronary artery followed by reperfusion. At a dose of 10 mg/kg, compound A significantly decreased arrhythmia scores and the total length of arrhythmias, whereas this was found to be ineffective at a dose of 3 mg/kg. Pre-treatment with 5-HD, a selective mitoKATP blocker, abolished the antiarrhythmic effect of compound A. Both diazoxide, a selective mitoKATP opener and HMR 1098, a selective sarcKATP blocker, significantly decreased the total length of arrhythmias. However, the combination of neither diazoxide nor compound A with HMR 1098 showed no additional therapeutic benefit. These results reveal that compound A may have a dose-dependent antiarrythmic effect, which is more pronounced than the antiarrhythmic effect of diazoxide. The antiarrhythmic effect of compound A may possibly depend on mitoKATP activation. © 2016, The Pharmaceutical Society of Korea

Precarious solidarities: ‘poisonous knowledge’ and the Academics for Peace in times of authoritarianism

Based on the case of Academics for Peace (BAK) in Turkey, this article reveals the conditions and trajectories that constitute precariousness and solidarity in the academic context of Turkey and the United Kingdom. Reflecting on a self‐ethnographic narrative, the main focus of the article revolves around the question of how to live an academic life when what we do and what we produce is perceived by both the public and the state as acts of potential threat to the integrity of nations and the well‐being of societies. What types of solidarity and forms of vulnerability and resilience emerge from these situations? How might the production of knowledge be transformed into a means and a place of solidarity? In the context of these questions, the article continues the search for possibilities that could emerge from precarious conditions and lead to another ethics or policy of coexistence in/outside the academic world