The challenge of remanufactured products: the role of returns policy and channel structure to reduce consumers' perceived risk

While remanufactured products represent an increasingly researched phenomenon in the literature, not much is known about consumers' understanding and acceptance of such products. This study explores this issue in the context of the theory of perceived risk (TPR), investigating return policy leniency and distribution channel choice as potential factors to foster remanufactured products' sales

Innovation and the circular economy: A systematic literature review

The circular economy emerged as an alternative model to the linear system, which now appears to be reaching its physical limitations. To transition to a circular economy, companies must not only be aware of but also engage in more sustainable practices. For such a transition, companies must rethink and innovate their business models and the ways they propose value to their clients while simultaneously considering environmental and social facets. This systematic literature review sought to map out from the company perspective the key topics interrelated with innovation and the circular economy, describing the internal and external factors to consider in such transition processes. Key lines of research were identified, and suggestions for future research and for facilitating movement toward a circular economy are provided. This work contributes to deepening the literature by identifying the priority areas concerning the circular economy and encouraging future research that meets international standards of excellence.info:eu-repo/semantics/publishedVersio

Prospective Observational Study of Pazopanib in Patients with Advanced Renal Cell Carcinoma (PRINCIPAL Study)

Background: Real-world data are essential to accurately assessing efficacy and toxicity of approved agents in everyday practice. PRINCIPAL, a prospective, observational study, was designed to confirm the real-world safety and efficacy of pazopanib in patients with advanced renal cell carcinoma (RCC). Subjects, Materials, and Methods: Patients with clear cell advanced/metastatic RCC and a clinical decision to initiate pazopanib treatment within 30 days of enrollment were eligible. Primary objectives included progression-free survival (PFS), overall survival (OS), objective response rate (ORR), relative dose intensity (RDI) and its effect on treatment outcomes, change in health-related quality of life (HRQoL), and safety. We also compared characteristics and outcomes of clinical-trial-eligible (CTE) patients, defined using COMPARZ trial eligibility criteria, with those of non-clinical-trial-eligible (NCTE) patients. Secondary study objectives were to evaluate clinical efficacy, safety, and RDI in patient subgroups. Results: Six hundred fifty-seven patients were enrolled and received ≥1 dose of pazopanib. Median PFS and OS were 10.3 months (95% confidence interval [CI], 9.2–12.0) and 29.9 months (95% CI, 24.7 to not reached), respectively, and the ORR was 30.3%. HRQoL showed no or little deterioration over time. Treatment-related serious adverse events (AEs) and AEs of special interest occurred in 64 (9.7%), and 399 (60.7%) patients, respectively. More patients were classified NCTE than CTE (85.2% vs. 14.8%). Efficacy of pazopanib was similar between the two groups. Conclusion: PRINCIPAL confirms the efficacy and safety of pazopanib in patients with advanced/metastatic RCC in a real-world clinical setting. Implications for Practice: PRINCIPAL is the largest (n = 657) prospective, observational study of pazopanib in patients with advanced/metastatic renal cell carcinoma, to the authors’ knowledge. Consistent with clinical trial results that often contain specific patient types, the PRINCIPAL study demonstrated that the effectiveness and safety of pazopanib is similarly safe and effective in patients with advanced kidney cancer in a real-world clinical setting. The PRINCIPAL study showed that patients with advanced kidney cancer who are treated with first-line pazopanib generally do not show disease progression for approximately 10 months and generally survive for nearly 30 months

Does Social Media Influence Business Performance? The Impact of Relational Benefits on Repurchase Intention and WOM

: Social media offer companies an unprecedented tool to establish and develop relationships with customers and to interact with them. So, the brand-customer relationships can be enhanced through Social media, which are able to deliver different kinds of benefits, namely monetary savings, recognition, social interaction, entertainment and exploration. Thus, the present study seeks to investigate the effects of social media\u2019s benefits\u2014specifically, its relational benefits\u2014derived from membership of and participation in brand pages in Social media. This study analyses their impact on the intention to repurchase the product/service and also the willingness to recommend the brand to other consumers. Data were collected through a quantitative study using an online survey, which recruited Italian respondents and providing data analysis via structural equation modelling. Findings show that only social and exploration benefits affect both the intention to repurchase and the willingness to widespread WOM, while monetary, recognition and entertainment benefits show no influence on the dependent variables. Such results offer a contribution, since they provide insights on a highly relevant phenomenon such as Social media across different-industries and different Social media

Preliminary evidence that subclinical enthesopathy may predict psoriatic arthritis in patients with psoriasis

la entesopatia asintomatica può essere un predittore indipendente di artropatoa psoriasic

The early psoriatic arthritis screening questionnaire: a simple and fast method for the identification of arthritis in patients with psoriasis

il manoscritto descrive la messa a punto di un questionario per la identificazione delle forme precoci di artrite psoriasic

Inflammation and nutritional status as predictors of physical performance and strenght loss during hospitalization.

OBJECTIVES: The aim of this study was to examine changes in physical performance and handgrip strength during hospitalization as well as to evaluate their interrelationship with inflammatory and nutritional status. DESIGN: Data were available on 302 elderly patients with a mean age of 80.83\ub17.14 years. Handgrip strength, gait speed and chair-stand test were assessed at admission and before discharge. In all subjects, serum CRP values and Mini Nutritional Assessment scores were also evaluated. RESULTS: The risk of worsening in chair-stand test performance was 4.2 (95% confidence interval (CI): 1.574-11.310) for subjects with simultaneous presence of malnutrition and CRP\u2a7e50 and 3.3\u2009mg/dl (95% CI: 1.127-9.423) for subjects with CRP\u2a7e50\u2009mg/l not malnourished in comparison with subjects with Mini Nutritional Assessment (MNA)\u2a7e24 and CRP\u2a7d10\u2009mg/l. The risk of handgrip strength loss was 8.8 (95% CI: 3.545-21.662) in subjects with simultaneous presence of malnutrition and CRP\u2a7e50 and 2.9\u2009\u2009mg/dl (95% CI: 1.223-6.783) in subjects with CRP\u2a7e50\u2009mg/l not malnourished in comparison with subjects with MNA\u2a7e24 and CRP\u2a7d10\u2009mg/l. CONCLUSIONS: Simultaneous presence of high CRP values and malnutrition determines an additive effect on muscle strength loss and physical performance.European Journal of Clinical Nutrition advance online publication, 31 August 2016; doi:10.1038/ejcn.2016.159

Review of social media’s influence on Airbnb accommodation’s booking intention

The impact of social media on the tourism industry has great significance for all stakeholders. The purpose of this paper is to highlight and comprehend how social media’s (Social Networking and Review Sites) influences accommodation’s booking intention, with regards to Airbnb accommodation. To achieve the purpose, the paper focuses on exploring the scope of social media, comprehending the different levels of exposure or usage of social media by different generations, and analyzing the influence of social media in booking Airbnb accommodations. Through these objectives, it intends to emphasize the role of social media in the tourism industry, as well as brings out the benefits for tourists across the globe. This research expresses the factors that are considered to influence Airbnb booking intention through a conceptual framework. In analyzing the scope of choosing Airbnb as a traveler’s accommodation, this study also demonstrates that social media is a useful tool in improving not only the quality of business but also increasing the revenue