Semantic and inferencing abilities in children with communication disorders

Background: Semantic and inferencing abilities have not been fully examined in children with communication difficulties. Aims: To investigate the inferential and semantic abilities of children with communication difficulties using newly designed tasks. Methods & Procedures: Children with different types of communication disorder were compared with each other and with three groups of typically developing children: those of the same chronological age and two groups of younger children. In total, 25 children aged 11 years with specific language impairment and 22 children, also 11 years of age, with primary pragmatic difficulties were recruited. Typically developing groups aged 11 (n = 35; age‐match), and those aged 9 (n = 40) and 7 (n = 37; language similar) also participated as comparisons. Outcomes & Results: For Semantic Choices, children with specific language impairment performed significantly more poorly than 9‐ and 11‐year‐olds, whilst the pragmatic difficulties group scored significantly lower than all the typically developing groups. Borderline differences between specific language impairment and pragmatic difficulties groups were found. For inferencing, children with communication impairments performed significantly below the 11‐year‐old peers, but not poorer than 9‐ and 7‐year‐olds, suggesting that this skill is in line with language ability. Six children in the pragmatic difficulties group who met diagnosis for autism performed more poorly than the other two clinical groups on both tasks, but not statistically significantly so. Conclusions: Both tasks were more difficult for those with communication impairments compared with peers. Semantic but not inferencing abilities showed a non‐significant trend for differences between the two clinical groups and children with pragmatic difficulties performed more poorly than all typically developing groups. The tasks may relate to each other in varying ways according to type of communication difficulty

Deploying a Communicating Automatic Weather Station on an Alpine Glacier

The cost and effort of installing and maintaining an automatic weather station (AWS) on a glacier may be mitigated by the possibility of gathering sensor data in near real-time, and of controlling and programming the station remotely. In this paper we report our experience with upgrading an existing AWS, operating over an Italian glacier, from a mere datalogger into a networked sensing station. Design choices, energy constraints and power-aware programming of the station determined by harsh environment are discussed. Deployment operations and results are described. The upgraded AWS provides low-power connectivity from a remote location and is able to serve as a base station for a wireless sensor network working in the glacier

Oil spill hazard bulletin

Dissemination Method: Web Product weblink: https://glamor.sincem.unibo.it The MSFD, the new Directive on Safety of offshore oil and gas operations (2013) and the European Maritime Safety Agency require robust tools for oil spill hazard mapping, from accidental to operational. In this activity WP7 and Marine Core Service products were coupled to Medslik-II oil spill model in order to produce, on request, an Oil Spill Hazard Bulletin based upon the hazard mapping data generated earlier in the project. This report contains background information and some examples of oil spill hazard bulletins for target Atlantic areas. The web-GIS Portal GLAMOR developed for Task 8.4 “Oil spill hazard mapping and disaster risk reduction best practices” is used to create the information content in the requested bulletins. Please note: bulletins are only produced on a request basis

Endothelial cells, endoplasmic reticulum stress and oxysterols

Oxysterols are bioactive lipids that act as regulators of lipid metabolism, inflammation, cell viability and are involved in several diseases, including atherosclerosis. Mounting evidence linked the atherosclerosis to endothelium dysfunction; in fact, the endothelium regulates the vascular system with roles in processes such as hemostasis, cell cholesterol, hormone trafficking, signal transduction and inflammation. Several papers shed light the ability of oxysterols to induce apoptosis in different cell lines including endothelial cells. Apoptotic endothelial cell and endothelial denudation may constitute a critical step in the transition to plaque erosion and vessel thrombosis, so preventing the endothelial damaged has garnered considerable attention as a novel means of treating atherosclerosis. Endoplasmic reticulum (ER) is the site where the proteins are synthetized and folded and is necessary for most cellular activity; perturbations of ER homeostasis leads to a condition known as endoplasmic reticulum stress. This condition evokes the unfolded protein response (UPR) an adaptive pathway that aims to restore ER homeostasis. Mounting evidence suggests that chronic activation of UPR leads to cell dysfunction and death and recently has been implicated in pathogenesis of endothelial dysfunction. Autophagy is an essential catabolic mechanism that delivers misfolded proteins and damaged organelles to the lysosome for degradation, maintaining basal levels of autophagic activity it is critical for cell survival. Several evidence suggests that persistent ER stress often results in stimulation of autophagic activities, likely as a compensatory mechanism to relieve ER stress and consequently cell death. In this review, we summarize evidence for the effect of oxysterols on endothelial cells, especially focusing on oxysterols-mediated induction of endoplasmic reticulum stress

Fgf9 inhibition of meiotic differentiation in spermatogonia is mediated by Erk-dependent activation of Nodal-Smad2/3 signaling and is antagonized by Kit Ligand

Both fibroblast growth factor 9 (Fgf9) and Kit Ligand (Kl) signal through tyrosine kinase receptors, yet they exert opposite effects on meiotic differentiation in postnatal spermatogonia, Fgf9 acting as a meiosis-inhibiting substance and Kl acting as a promoter of the differentiation process. To understand the molecular mechanisms that might underlie this difference, we tried to dissect the intracellular signaling elicited by these two growth factors. We found that both Fgf9 and Kl stimulate Erk1/2 activation in Kit+ (differentiating) spermatogonia, even though with different time courses, whereas Kl, but not Fgf9, elicits activation of the Pi3k-Akt pathway. Sustained Erk1/2 activity promoted by Fgf9 is required for induction of the autocrine Cripto-Nodal-Smad2/3 signaling loop in these cells. Nodal signaling, in turn, is essential to mediate Fgf9 suppression of the meiotic program, including inhibition of Stra8 and Scp3 expression and induction of the meiotic gatekeeper Nanos2. On the contrary, sustained activation of the Pi3k-Akt pathway is required for the induction of Stra8 expression elicited by Kl and retinoic acid. Moreover, we found that Kl treatment impairs Nodal mRNA expression and Fgf9-mediated Nanos2 induction, reinforcing the antagonistic effect of these two growth factors on the meiotic fate of male germ cells

Beam-based characterization of plasma density in a capillary-discharge waveguide

Next-generation plasma-based accelerators can push electron bunches to gigaelectronvolt energies within centimeter distances. In these devices, the accelerating force is provided by a driver pulse, either a laser pulse or a particle bunch, that loses its energy into the plasma generating huge electric fields up to tens of GV/m. The stability of such fields strongly depends on plasma density, whose exact value should be precisely known and controlled. However, currently available methods based on spectroscopic or interferometric techniques find it very difficult to measure plasma density lower than 1015–16 cm−3 in capillary-discharge waveguides. Here, we present a novel diagnostic tool that allows us to estimate the average density of a plasma capillary by probing it with an ultra-relativistic electron beam. The plasma density and the generated accelerating field are inferred by analyzing the beam longitudinal phase space after its interaction with the plasma. The results are validated by simulations showing excellent agreement

A Statistical Analysis of Supersymmetric Dark Matter in the MSSM after WMAP

We study supersymmetric dark matter in the general flavor diagonal MSSM by means of an extensive random scan of its parameter space. We find that, in contrast with the standard mSUGRA lore, the large majority of viable models features either a higgsino or a wino-like lightest neutralino, and yields a relic abundance well below the WMAP bound. Among the models with neutralino relic density within the WMAP range, higgsino-like neutralinos are still dominant, though a sizeable fraction of binos is also present. In this latter case, relic density suppression mechanisms are shown to be essential in order to obtain the correct neutralino abundance. We then carry out a statistical analysis and a general discussion of neutralino dark matter direct detection and of indirect neutralino detection at neutrino telescopes and at antimatter search experiments. We point out that current data exclude only a marginal portion of the viable parameter space, and that models whose thermal relic abundance lies in the WMAP range will be significantly probed only at future direct detection experiments. Finally, we emphasize the importance of relic density enhancement mechanisms for indirect detection perspectives, in particular at future antimatter search experiments.Comment: 39 pages, 25 figure

Emissivity characterization of different stainless steel textiles in the infrared range

We experimentally investigated the infrared properties of a set of steel textiles, prepared using different type of fabrics. Infrared emission of the textiles was characterized in the mid-infrared range, i.e. 8÷14 mm, by observing their temperature evolution under heating regime with a focal plane array (FPA) infrared camera. Standard test method for measuring and compensating emissivity using infrared imaging radiometers was applied to the set of metallic textiles. The obtained experimental results allowed to retrieve the infrared emissivity at different applied temperatures. Although their infrared emission show some differences depending on the specific fabric, all the investigated textiles composed of steel yarns appear to be suitable for thermal shielding applications. Finally, the measured data were interpreted by means of the finite-difference time-domain (FDTD) numerical simulations as well as using Plank's theory of black-body radiation